Safety Evaluation of Lactulose Syrup in Rats

Journal of Food Science and Technology

Volumn 36, Issue 4, 1999, Pages 355-357

  Baskaran, V ^a   Narasimhamurthy, K ^a   Nagendraand, R ^a   Lokesh, B R ^a  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

Bifidogenic factor; Diarrhoea; Lactulose; Safety

Indexed keywords

EID: 0001594194     PISSN: 00221155     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Abe F, Ishibashi N, Shimamura S (1995) Effect of administration of bifidobacteria and lactic acid bacteria in new born calves and piglets. J Dairy Sci 78:2838-2846
2. Andrews GR (1984) Distinguishing pasteurized, UHT and sterilized milks by their lactulose content. J Soc Dairy Tech 37:92-95
3. Baglioni A, Dubini F (1976) Lactulose, a toxicological evaluation. Bollettino Chemico Farmacentico 115:596-606
4. Bezkorovainy A, Miller-Catchpole R (1989) Biochemistry and Physiology of Bifidobacteria, CRC Press, Florida, pp 190-193
5. Bircher J, Zurich MD, Muller J, Zurich MD (1966) Treatment of portal systemic encephalopathy with lactulose. Lancet 23:890-892
6. Cummings JH, Macfarlane GT, Draser BS (1989) The gut microflora and Its significance. In: Whitehead, R (ed) Gastrointestinal and Oesophageal Pathology. Churchill Livingstone, London, pp 201-219
7. Dahlqvist A, Gryboski JD (1965) Inability of the human small intestinal lactase to hydrolyze lactulose. Biochem Biophys Acta 110:635-636
8. Engel CE. Olinger PM (1979) High pressure liquid chromatographic determination of saccharides in corn syrups: Collaborative study. J Assoc Off Anal Chem 62:527-532
9. Greig R, Klostermeyer H (1983) Formation of lactulose during heat treatment of milk. Milchwissenschaft 38:475-477
10. Hodge JK, Rendleman JA, Nelson EC (1972) Properties of maltose. Cereal Sci Today 17:180-188
11. Ito M, Deguchi Y, Matsurnoto K, Kimura M, Orodera N, Yajima T (1993) Influence of galactooligosaccharides on the human faecal microflora. J Nut Sci Vitaminol 39:635-640
12. Krishnakumari MK, Rajalakshmi D, Sreenivasan V, Ramasuridaram CP (1979) Feeding responses of young and adult albino rats to mixed basal diet. Proc Ind Acad Sci 88: 367-375
13. Litchfield JT, Wilcoxon (1949) A simplified method of evaluating dose effect experiments. J Pharm Exp Ther 96:99-113
14. Makinen KK, Rekola M (1975) Comparison between sucrose and lactulose in a suspended salivary system. J Dental Res 54:1244-1248
15. Mendez A, Olano A (1979) Lactulose. A review of some chemical properties and applications in infant nutrition and medicine. Dairy Sci Abst 41:531-535
16. Michaelis OE, Szepesi B (1976) Effect of galactose containing disaccharides and trisaccharides on hepatic enzyme responses in starved-refed rats. Nutri Res Int 14:553-559
17. Michaelis OE, Nace CS, Szepesi B (1978) Effect of refeeding raw and cooled starches on hepatic enzyme activities of rats. Brit J Nutri 39:85-89
18. Michaelis OE, Emberland JJ, Hicks KB (1986) Effect of feeding maltulose and lactulose on hepatic lipogenic enzyme activities in the rat. Nutri Res 6:857-861
19. Nagendra R, Venkat Rao S (1992) An improved colorimetric method for the estimation of lactulose in lactose-lactulose mixtures. Food Chem 43:399-402
20. Nagendra R, Vishwanatha S, Arunkumar S, Krishnamurthy B, Venkat Rao S (1995a) Effect of feeding milk formula containing lactulose to infants on their faecal bifidobacterial flora. Nutri Res 6:15-24
21. Nagendra R, Mahadevamma, Baskaran V, Venkat Rao S (1995b) Shelf-life of spray-dried infant formula supplemented with lactulose. J Food Proc Pres 19:303-315
22. Nagendra R, Vishwanatha S, Narasimhamurthy K, Venkat Rao S (1995c) Effect of incorporating lactulose in infant formula on absorption and retention of nitrogen, calcium, phosphorus and iron in rats. Int Dairy J 4:779-788
23. Oku T, Tokunaga T, Hosoya N (1984) Non-digestibility of new sweetener, Neosugar in the rat. J Nutri 114:1574-1581
24. Oku T, Noda K (1990) Influence of chronic ingestion of newly developed sweetener, erythritol, on growth and gastrointestinal function of the rats. Nutri Res 10:989-996
25. Oku T (1994) Special physiological function of newly developed mono-and oligo-saccharides. In: Goldberg I (ed) Functional Foods: Designer Foods, Pharma Foods, Neutraceuticals. Thomson Publishing Co., Chapman and Hall, New York, pp 202-218
26. Tamura Y, Mizota T, Shimamura S, Tomita M (1993) Lactulose and its application to the food and pharmaceutical industries. Bull Int Dairy Fedn No. 289 pp 43-48