LIF, NGF, and the cell body response to axotomy

Neuroscientist

Volumn 3, Issue 3, 1997, Pages 176-185

  Zigmond, Richard E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axotomy; Cytokines; Leukemia inhibitory factor; Nerve growth factor; Neuropeptides; Regeneration

Indexed keywords

EID: 0001583289     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385849700300311     Document Type: Review

References (66)

1. Snider WD, Elliott JL, Yan Q. Axotomy-induced neuronal death during development. J Neurobiol 1992;23:1231-1246.
2. Lieberman AR. The axon reaction: a review of the principle features of perikaryal responses to axon injury. In: Pfeiffer CC, Smythies JR, editors. International review of neurobiology. Vol. 14. New York: Academic Press 1971;49-124.
3. Matthews MR, Raisman G. A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the rat. Proc R Soc Lond B Biol Sci 1972;181:43-79.
4. Watson WE. Cellular response to axotomy and to related procedures. Br Med Bull 1974;30:112-115.
5. Zigmond RE, Hyatt-Sachs H, Mohney RP, et al. Changes in neuropeptide phenotype after axotomy of adult peripheral neurons and the role of leukemia inhibitory factor. Perspect Dev Neurobiol 1996;4:75.
6. Hårkönen M. Carboxylic esterases, oxidative enzymes and catecholamines in the superior cervical ganglion of the rat and the effect of pre- and post-ganglionic nerve division. Acta Physiol Scand Suppl 1964;63:(Suppl 237)1-94.
7. Cheah TB, Geffen LB. Effects of axonal injury on norepinephrine tyrosine hydroxylase, and monoamine oxidase levels in sympathetic ganglia. J Neurobiol 1973;4:443-452.
8. Koo EH, Hoffman RN, Price DL. Levels of neurotransmitter and cytoskeletal protein mRNAs during nerve regeneration in sympathetic ganglia. Brain Res 1988;449:361-363.
9. Sun Y, Zigmond RE. Involvement of leukemia inhibitory factor in the increases in galanin and vasoactive intestinal peptide mRNA and the decreases in neuropeptide Y and tyrosine hydroxylase mRNA after axotomy of sympathetic neurons. J Neurochem 1996; 67:1751-1760.
10. Hebb C, Silver A. Axoplasmic flow of protein In: Peeters H, editor. Protides of the biological fluids. Amsterdam: Elsevier 1966; 179-180.
11. Wooten GF, Park DH, Joh TH, Reis DJ. Immunochemical demonstration of reversible reduction in choline acetyltransferase concentration in rat hypoglossal nucleus after hypoglossal nerve transection. Nature 1978;275:324-325.
12. Piehl F, Arvidsson U, Johnson H, et al. GAP-43, αFGF, CCK and α- and β-CGRP in rat spinal motoneurons subjected to axotomy and/or dorsal root severance. Eur J Neurosci 1993;5:1321-1333.
13. Jessell T, Tsunoo A, Kanazawa I, Otsuka M. Substance P: depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons. Brain Res 1979; 168:247-259.
14. Nielsch U, Keen P. Reciprocal regulation of tachykinin- and vasoactive intestinal peptide-gene expression in rat sensory neurones following cut and crush injury. Brain Res 1989;481:25-30.
15. Noguchi K, Senba E, Morita Y, Sato M, Tohyama M. Prepro-VIP and preprotachykinin mRNAs in the rat dorsal root ganglion cells following peripheral axotomy. Mol Brain Res 1989;6:327-330.
16. Schwarzacher HG. Der cholinesterasegehalt motorischer nervenzellen während der axonalen reaktion. Acta Anat (Basel) 1958;32: 51-65.
17. Rotter A, Birdsall NJM, Burgen ASV, Field PM, Raisman G. Axotomy causes loss of muscarinic receptors and loss of synaptic contacts in the hypoglossal nucleus. Nature 1977;266:734-735.
18. Rotter A, Schultz CM, Frostholm A. Regulation of glycine receptor binding in the mouse hypoglossal nucleus in response to axotomy. Brain Res Bull 1984;13:487-492.
19. Senba E, Simmons DM, Wada E, Wada K, Swanson LW. RNA levels of neuronal nicotinic acetylcholine receptor subunits are differently regulated in axotomized facial motoneurons: an in situ hybridization study. Mol Brain Res 1990;8:349-353.
20. Sinicropi DV, Kauffman FC, Burt DR. Axotomy in rat sympathetic ganglia: Reciprocal effects on muscarinic receptor binding and 6-phosphogluconate dehydrogenase activity. Brain Res 1979; 161:560-565.
21. Fumagalli L, de Renzis G. α-Bungarotoxin binding sites in the rat superior cervical ganglion are influenced by postganglionic axotomy. Neuroscience 1980;5:611-616.
22. Zhou Y, Deneris E, Zigmond RE. Regulation of nicotinic receptor subunit transcripts in the superior cervical ganglion (SCG) after axotomy. Soc Neurosci Abstr 1996;22:1961.
23. Blinzinger K, Kreutzberg G. Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z Zellforsch Mikrosk Anat 1968;85:145-157.
24. Matthews MR, Nelson VH. Detachment of structurally intact nerve endings from chromatolytic neurones of rat superior cervical ganglion during the depression of synaptic transmission induced by post-ganglionic axotomy. J Physiol (Lond) 1975;245:91-135.
25. Faucon Biguet N, Rittenhouse AR, Mallet J, Zigmond RE. Pre-ganglionic nerve stimulation increases RNA levels of tyrosine hydroxylase in the rat superior cervical ganglion. Neurosci Lett 1989;104:189-194.
26. Hoffman PN. Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons. J Neurosci 1989;9:893-897.
27. Hall ME, Wilson DL, Stone GC. Changes in synthesis of specific proteins following axotomy: Detection with two-dimensional gel electrophoresis. J Neurobiol 1978;9:353-366.
28. Pearson RCA, Taylor N, Snyder SH. Tubulin messenger RNA: in situ hybridization reveals bilateral increases in hypoglossal and facial nuclei following nerve transection. Brain Res 1988;463: 245-249.
29. Tetzlaff W, Alexander SW, Miller FD, Bisby MA. Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43. J Neurosci 1991; 11:2528-2544.
30. McGregor GP, Gibson SJ, Sabate IM, et al. Effect of peripheral nerve section and nerve crush on spinal cord neuropeptides in the rat; increased VIP and PHI in the dorsal horn. Neuroscience 1984; 13:207-216.
31. Shehab SAS, Atkinson ME. Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons. Brain Res 1986;372:37-44.
32. Hyatt-Sachs H, Schreiber RC, Bennett TA, Zigmond RE. Phenotypic plasticity in adult sympathetic ganglia in vivo: effects of deafferentation and axotomy on the expression of vasoactive intestinal peptide. J Neurosci 1993;13:1642-1653.
33. Mohney RP, Siegel R, Zigmond RE. Galanin and vasoactive intestinal peptide messenger RNA expression increase following axotomy of the adult rat SCG. J Neurobiol 1994;25:108-118.
34. Zhang X, Verge VMK, Wiesenfeld-Hallin Z, Piehl F, Hökfelt T. Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin. Exp Brain Res 1993;93:450-461.
35. Gozes I, Brenneman DE. Neuropeptides as growth and differentiation factors in general and VIP in particular. J Mol Neurosci 1993;4:1-9.
36. Pincus DW, DiCicco-Bloom EM, Black IB. Vasoactive intestinal peptide regulates mitosis, differentiation and survival of cultured sympathetic neuroblasts. Nature 1990;343:564-567.
37. Calvo JR, Montilla ML, Guerrero JM, Segura JJ. Expression of VIP receptors in mouse peritoneal macrophages: functional and molecular characterization. J Neuroimmunol 1994;50:85-93.
38. Griffin JW, George R, Ho T. Macrophage systems in peripheral nerves. A review. J Neuropathol Exp Neurol 1993;52:553-560.
39. Schreiber RC, Shadiack AM, Bennett TA, Zigmond RE. Changes in the macrophage population of the rat superior cervical ganglion after postganglionic nerve injury. J Neurobiol 1995;27:141-153.
40. Tanaka S, Koike T. Vasoactive intestinal peptide suppresses neuronal cell death induced by nerve growth factor deprivation in rat sympathetic ganglion cells in vitro. Neuropeptides 1994;26:103-111.
41. Schreiber RC, Hyatt-Sachs H, Bennett TA, Zigmond RE. Galanin expression increases in adult rat sympathetic neurons after axotomy. Neuroscience 1994;60:17-27.
42. May V, Brandenburg CA, Braas KM. Axotomy and decentralization regulate pituitary adenylate cyclase activating polypeptide (PACAP) expression in rat superior cervical ganglion. Soc Neurosci Abstr 1996;22:1998.
43. Rao MS, Sun Y, Vaidyanathan U, Landis SC, Zigmond RE. Regulation of substance P is similar to that of vasoactive intestinal peptide after axotomy or explantation of the rat superior cervical ganglion. J Neurobiol 1993;24:571-580.
44. Villar MJ, Wiesenfeld-Hallin W, Xu X-J, Theodorsson E, Emson PC, Hökfelt T. Further studies on galanin- substance P, and CGRP-like immunoreactivities in primary sensory neurons and spinal cord: effects of dorsal rhizotomies and sciatic nerve lesions. Exp Neurol 1991;112:29-39.
45. Wakisaka S, Kajander KC, Bennett GJ. Increased neuropeptide Y (NPY)-like immunoreactivity in rat sensory neurons following peripheral axotomy. Neurosci Lett 1991;124:200-203.
46. Zhang Y-Z, Hannibal J, Zhao Q, et al. Pituitary adenylate cyclase activating peptide expression in the rat dorsal root ganglia: up-regulation after peripheral nerve injury. Neuroscience 1996;74: 1099-1110.
47. Saika T, Senba E, Noguchi K, et al. Changes in expression of peptides in rat facial motoneurons after facial nerve crushing and resection. Mol Brain Res 1991;11:187-196.
48. Hyatt-Sachs H, Bachoo M, Schreiber R, Vaccariello SA, Zigmond RE. Chemical sympathectomy and postganglionic nerve transection similarly increase galanin and VIP mRNA but not the peptides themselves. J Neurobiol 1996;30:543-555.
49. Korsching S, Thoenen H. Treatment with 6-hydroxydopamine and colchicine decreases nerve growth factor levels in sympathetic ganglia and increases them in the corresponding target tissues. J Neurosci 1985;5:1058-1061.
50. Knyihár-Csillik E, Kreutzberg GW, Raivich G, Bsillik B. A case for transmitter plasticity at the molecular level: axotomy-induced VIP increase in the upper spinal dorsal horn is related to blockade of retrograde axoplasmic transport of nerve growth factor in the peripheral nerve. Acta Histochem 1991;91:77-83.
51. Sun Y, Landis SC, Zigmond RE. Signals triggering the induction of leukemia inhibitory factor in sympathetic superior cervical ganglia and their nerve trunks after axonal injury. Mol Cell Neurosci 1996;7:152-163.
52. Zigmond RE. Retrograde and paracrine influences on neuropeptide expression in sympathetic neurons after axonal injury. In: Ransohoff RM, Benveniste EN, editors. Cytokines and the CNS: development, defenses and disease. Boca Raton, FL: CRC Press 1995;169-186.
53. Sun Y, Rao MS, Zigmond RE, Landis SC. Regulation of vasoactive intestinal peptide expression in sympathetic neurons in culture: the role of cholinergic differentiation factor/leukemia inhibitory factor. J Neurobiol 1994;25:415-430.
54. Bazan JF. Neuropoietic cytokines in the hematopoietic fold. Neuron 1991;7:197-208.
55. Inoue M, Nakayama, C, Noguchi H. Activating mechanism of CNTF and related cytokines. Mol Neurobiol 1996; 12,195-209.
56. Stahl N, Yancopoulos GD. The tripartite CNTF receptor complex: Activation and signaling involves components shared with other cytokines. J Neurobiol 1994;25:1454-1466.
57. Segal RA, Greenberg ME. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 1996; 19:463-489.
58. Rao MS, Sun Y, Escary JL, et al. Leukemia inhibitory factor mediates an injury response but not a developmental transmitter switch in sympathetic neurons. Neuron 1993;11:1175-1185.
59. Sun Y, Zigmond RE. Leukemia inhibitory factor induced in the sciatic nerve after axotomy is involved in the induction of galanin in sensory neurons. Eur J Neurosci 1996;8:2213-2220.
60. Sun Y. Regulation and function of leukemia inhibitory factor in mature sympathetic ganglia after axotomy (Ph.D. thesis). Cleveland (OH): Case Western Reserve University 1996.
61. Curtis R, Scherer SS, Somogyi R, et al. Retrograde axonal transport of LIF is increased by peripheral nerve injury: correlation with increased LIF expression in distal nerve. Neuron 1994;12: 191-204.
62. Heumann R, Korsching S, Bandtlow C, Thoenen H. Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection. J Cell Biol 1987;104:1623-1631.
63. Verge VMK, Richardson PM, Wiesenfeld-Hallin Z, Hökfelt T. Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons. J Neurosci 1995;15:2081-2096.
64. Zigmond RE, Shadiack AM, Sun Y. Antiserum to nerve growth factor (NGF) alters neuropeptide expression in the superior cervical ganglion (SCG) and dorsal root ganglion (DRG) in vivo. Soc Neurosci Abstr 1995;21:1052.
65. Njå A, Purves D. The effects of nerve growth factor and its antiserum on synapses in the superior cervical ganglion of the guinea-pig. J Physiol (Lond) 1978;277:53-75.
66. Shadiack AM, Vaccariello SA, Zigmond RE. Regulation of galanin and neuropeptide Y (NPY) in intact sympathetic neurons by nerve growth factor (NGF) and leukemia inhibitory factor (LIF). Soc Neurosci Abstr 1996;22:1962.