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For recent synthesis of tert-leucine see: (a) Münster, P.; Steglich, W. Synthesis 1987, 223. (b) Yamada, T.; Motoyama, N.; Taniguchi, T.; Kazuta, Y.; Miyazawa, T.; Kuwata, S.; Matsumoto, K.; Sugiura, M. Chem. Lett. 1987, 723. (c) Kunz; H.; Pfrengle, W.; Sager, W. Tetrahedron Lett. 1989, 30, 4109. (d) Evans, D. A.; Britton, T. C.; Ellman, J. A.; Dorow, R. L. J. Am. Chem. Soc. 1990, 112, 4011. (e) Kunz, H.; Pfrengle, W.; Rück, K.; Sager, W. Synthesis 1991, 1039. (f) Corey, E. J.; Link, J. O. J. Am. Chem. Soc. 1992, 114, 1906. (g) Obrecht, D.; Spiegler, C.; Schönholzer, P.; Müller, K.; Heimgartner, H.; Stierli, F. Helv. Chim. Acta 1992, 75, 1666. (h) Inaba, T.; Kozono, I.; Fujita, M.; Ogura, K. Bull. Chem. Soc. Jpn. 1992, 65, 2359. (i) Durst, T.; Koh, K. Tetrahedron Lett. 1992, 33, 6799. (k) Clive, D. L. J.; Etkin, N. Tetrahedron Lett. 1994, 35, 2459.
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For recent synthesis of tert-leucine see: (a) Münster, P.; Steglich, W. Synthesis 1987, 223. (b) Yamada, T.; Motoyama, N.; Taniguchi, T.; Kazuta, Y.; Miyazawa, T.; Kuwata, S.; Matsumoto, K.; Sugiura, M. Chem. Lett. 1987, 723. (c) Kunz; H.; Pfrengle, W.; Sager, W. Tetrahedron Lett. 1989, 30, 4109. (d) Evans, D. A.; Britton, T. C.; Ellman, J. A.; Dorow, R. L. J. Am. Chem. Soc. 1990, 112, 4011. (e) Kunz, H.; Pfrengle, W.; Rück, K.; Sager, W. Synthesis 1991, 1039. (f) Corey, E. J.; Link, J. O. J. Am. Chem. Soc. 1992, 114, 1906. (g) Obrecht, D.; Spiegler, C.; Schönholzer, P.; Müller, K.; Heimgartner, H.; Stierli, F. Helv. Chim. Acta 1992, 75, 1666. (h) Inaba, T.; Kozono, I.; Fujita, M.; Ogura, K. Bull. Chem. Soc. Jpn. 1992, 65, 2359. (i) Durst, T.; Koh, K. Tetrahedron Lett. 1992, 33, 6799. (k) Clive, D. L. J.; Etkin, N. Tetrahedron Lett. 1994, 35, 2459.
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For recent synthesis of tert-leucine see: (a) Münster, P.; Steglich, W. Synthesis 1987, 223. (b) Yamada, T.; Motoyama, N.; Taniguchi, T.; Kazuta, Y.; Miyazawa, T.; Kuwata, S.; Matsumoto, K.; Sugiura, M. Chem. Lett. 1987, 723. (c) Kunz; H.; Pfrengle, W.; Sager, W. Tetrahedron Lett. 1989, 30, 4109. (d) Evans, D. A.; Britton, T. C.; Ellman, J. A.; Dorow, R. L. J. Am. Chem. Soc. 1990, 112, 4011. (e) Kunz, H.; Pfrengle, W.; Rück, K.; Sager, W. Synthesis 1991, 1039. (f) Corey, E. J.; Link, J. O. J. Am. Chem. Soc. 1992, 114, 1906. (g) Obrecht, D.; Spiegler, C.; Schönholzer, P.; Müller, K.; Heimgartner, H.; Stierli, F. Helv. Chim. Acta 1992, 75, 1666. (h) Inaba, T.; Kozono, I.; Fujita, M.; Ogura, K. Bull. Chem. Soc. Jpn. 1992, 65, 2359. (i) Durst, T.; Koh, K. Tetrahedron Lett. 1992, 33, 6799. (k) Clive, D. L. J.; Etkin, N. Tetrahedron Lett. 1994, 35, 2459.
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For recent synthesis of tert-leucine see: (a) Münster, P.; Steglich, W. Synthesis 1987, 223. (b) Yamada, T.; Motoyama, N.; Taniguchi, T.; Kazuta, Y.; Miyazawa, T.; Kuwata, S.; Matsumoto, K.; Sugiura, M. Chem. Lett. 1987, 723. (c) Kunz; H.; Pfrengle, W.; Sager, W. Tetrahedron Lett. 1989, 30, 4109. (d) Evans, D. A.; Britton, T. C.; Ellman, J. A.; Dorow, R. L. J. Am. Chem. Soc. 1990, 112, 4011. (e) Kunz, H.; Pfrengle, W.; Rück, K.; Sager, W. Synthesis 1991, 1039. (f) Corey, E. J.; Link, J. O. J. Am. Chem. Soc. 1992, 114, 1906. (g) Obrecht, D.; Spiegler, C.; Schönholzer, P.; Müller, K.; Heimgartner, H.; Stierli, F. Helv. Chim. Acta 1992, 75, 1666. (h) Inaba, T.; Kozono, I.; Fujita, M.; Ogura, K. Bull. Chem. Soc. Jpn. 1992, 65, 2359. (i) Durst, T.; Koh, K. Tetrahedron Lett. 1992, 33, 6799. (k) Clive, D. L. J.; Etkin, N. Tetrahedron Lett. 1994, 35, 2459.
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For recent synthesis of tert-leucine see: (a) Münster, P.; Steglich, W. Synthesis 1987, 223. (b) Yamada, T.; Motoyama, N.; Taniguchi, T.; Kazuta, Y.; Miyazawa, T.; Kuwata, S.; Matsumoto, K.; Sugiura, M. Chem. Lett. 1987, 723. (c) Kunz; H.; Pfrengle, W.; Sager, W. Tetrahedron Lett. 1989, 30, 4109. (d) Evans, D. A.; Britton, T. C.; Ellman, J. A.; Dorow, R. L. J. Am. Chem. Soc. 1990, 112, 4011. (e) Kunz, H.; Pfrengle, W.; Rück, K.; Sager, W. Synthesis 1991, 1039. (f) Corey, E. J.; Link, J. O. J. Am. Chem. Soc. 1992, 114, 1906. (g) Obrecht, D.; Spiegler, C.; Schönholzer, P.; Müller, K.; Heimgartner, H.; Stierli, F. Helv. Chim. Acta 1992, 75, 1666. (h) Inaba, T.; Kozono, I.; Fujita, M.; Ogura, K. Bull. Chem. Soc. Jpn. 1992, 65, 2359. (i) Durst, T.; Koh, K. Tetrahedron Lett. 1992, 33, 6799. (k) Clive, D. L. J.; Etkin, N. Tetrahedron Lett. 1994, 35, 2459.
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For recent synthesis of tert-leucine see: (a) Münster, P.; Steglich, W. Synthesis 1987, 223. (b) Yamada, T.; Motoyama, N.; Taniguchi, T.; Kazuta, Y.; Miyazawa, T.; Kuwata, S.; Matsumoto, K.; Sugiura, M. Chem. Lett. 1987, 723. (c) Kunz; H.; Pfrengle, W.; Sager, W. Tetrahedron Lett. 1989, 30, 4109. (d) Evans, D. A.; Britton, T. C.; Ellman, J. A.; Dorow, R. L. J. Am. Chem. Soc. 1990, 112, 4011. (e) Kunz, H.; Pfrengle, W.; Rück, K.; Sager, W. Synthesis 1991, 1039. (f) Corey, E. J.; Link, J. O. J. Am. Chem. Soc. 1992, 114, 1906. (g) Obrecht, D.; Spiegler, C.; Schönholzer, P.; Müller, K.; Heimgartner, H.; Stierli, F. Helv. Chim. Acta 1992, 75, 1666. (h) Inaba, T.; Kozono, I.; Fujita, M.; Ogura, K. Bull. Chem. Soc. Jpn. 1992, 65, 2359. (i) Durst, T.; Koh, K. Tetrahedron Lett. 1992, 33, 6799. (k) Clive, D. L. J.; Etkin, N. Tetrahedron Lett. 1994, 35, 2459.
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For recent synthesis of tert-leucine see: (a) Münster, P.; Steglich, W. Synthesis 1987, 223. (b) Yamada, T.; Motoyama, N.; Taniguchi, T.; Kazuta, Y.; Miyazawa, T.; Kuwata, S.; Matsumoto, K.; Sugiura, M. Chem. Lett. 1987, 723. (c) Kunz; H.; Pfrengle, W.; Sager, W. Tetrahedron Lett. 1989, 30, 4109. (d) Evans, D. A.; Britton, T. C.; Ellman, J. A.; Dorow, R. L. J. Am. Chem. Soc. 1990, 112, 4011. (e) Kunz, H.; Pfrengle, W.; Rück, K.; Sager, W. Synthesis 1991, 1039. (f) Corey, E. J.; Link, J. O. J. Am. Chem. Soc. 1992, 114, 1906. (g) Obrecht, D.; Spiegler, C.; Schönholzer, P.; Müller, K.; Heimgartner, H.; Stierli, F. Helv. Chim. Acta 1992, 75, 1666. (h) Inaba, T.; Kozono, I.; Fujita, M.; Ogura, K. Bull. Chem. Soc. Jpn. 1992, 65, 2359. (i) Durst, T.; Koh, K. Tetrahedron Lett. 1992, 33, 6799. (k) Clive, D. L. J.; Etkin, N. Tetrahedron Lett. 1994, 35, 2459.
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For recent synthesis of tert-leucine see: (a) Münster, P.; Steglich, W. Synthesis 1987, 223. (b) Yamada, T.; Motoyama, N.; Taniguchi, T.; Kazuta, Y.; Miyazawa, T.; Kuwata, S.; Matsumoto, K.; Sugiura, M. Chem. Lett. 1987, 723. (c) Kunz; H.; Pfrengle, W.; Sager, W. Tetrahedron Lett. 1989, 30, 4109. (d) Evans, D. A.; Britton, T. C.; Ellman, J. A.; Dorow, R. L. J. Am. Chem. Soc. 1990, 112, 4011. (e) Kunz, H.; Pfrengle, W.; Rück, K.; Sager, W. Synthesis 1991, 1039. (f) Corey, E. J.; Link, J. O. J. Am. Chem. Soc. 1992, 114, 1906. (g) Obrecht, D.; Spiegler, C.; Schönholzer, P.; Müller, K.; Heimgartner, H.; Stierli, F. Helv. Chim. Acta 1992, 75, 1666. (h) Inaba, T.; Kozono, I.; Fujita, M.; Ogura, K. Bull. Chem. Soc. Jpn. 1992, 65, 2359. (i) Durst, T.; Koh, K. Tetrahedron Lett. 1992, 33, 6799. (k) Clive, D. L. J.; Etkin, N. Tetrahedron Lett. 1994, 35, 2459.
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note
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It should be noted that the ester 4o and should be prepared directly before use or should be stored at -50°C to avoid decomposition.
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77
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note
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Obtained by Pd(II)-catalyzed coupling of pent-2-en-4-yn-1-ol and iodotoluene.
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