High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts

Xenotransplantation

Volumn 4, Issue 3, 1997, Pages 127-131

  Galili, Uri ^a   Minanov, Oktavijan P ^b   Michler, Robert E ^b   Stone, Kevin R ^c  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b New York Presbyterian Hospital Columbia University Medical Center   (United States)

^c Stone Clinic   (United States)

Author keywords

Anti Gal; Xenoreactive antibodies; Xenotransplantation

Indexed keywords

EID: 0001458942     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.1997.tb00175.x     Document Type: Review

References (27)

1. GALILI U. Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: A major obstacle for xenotrans-plantation in humans. Immunol Today 1993:14:480.
2. GOOD H, COOPER DKC, MALCOLM AJK, IPPOLITO RM, KOREN E, NEETHLING FA, YE Y, ZUHDI N, LAMONTAGNE LR. Identification of carbohydrate structures which bind human anti-porcine antibodies: implications for discordant grafting in man. Transplant Proc 1992:24:559.
3. SANDRIN M, VAUGHAN HA, DABKOWSKI PL, MCKENZI IFC. Anti-pig IgM antibodies in human serum react predominantly with Galα1-3Gal epitopes. Proc Natl Acad Sci USA 1993:90:11391.
4. COLLINS BH, COTTERELL AH, MCCCRRY KR, ALVARADO CG, MAGEE JC, PARKER W, PLATT JL. Cardiac xenografts between primate species provide evidence of the α-galactosyl determinant in hyperacute rejection. J Immunol 1994: 154:5500.
5. BYRNE, GW, MCCURRY, KR, MARTIN, MJ, MCCLELLAN, SM, PLATT, JL, LOGAN, JS. Transgenic pigs expressing human CD59 and decay accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 1997:63:149.
6. Cozzi E, WHITE DJG. The generation of transgenic pigs as potential organ donors for humans. Nature Med 1995; 1:964.
7. GALILI U, RACHMILEWITZ EA, PELEG A, FLECHNER I. A unique natural human IgG antibody with anti-α-galactosyl specificity. J Exp Med 1984:160:1519.
8. HAMADEH RM, GALILI U, ZHOU P, GRIFFIS JM. Human secretions contain IgA, IgG and IgM anti-Gal (anti-α-galactosyl) antibodies. Clin Diagn Lab Immunol 1995: 2: 125.
9. PARKER W, BRUNO O, HOLZKECHT ZE, PLATT JE. Characterization and affinity isolation of xenoreactive human natural antibodies. J Immunol 1994:153:3791.
10. GALILI U, ANARAKI F, THALL A, HILL-BLACK C, RADIC M. One percent of circulating B lymphocytes are capable of producing the natural anti-Gal antibody. Blood 1993: 82:2485.
11. H3 and the presence of somatic mutations. J Immunol 1995:155:1276.
12. GALILI U, MANDRELL RE, HAMAHDEH RM, SHOHET SB, GRIFFIS JM. Interaction between human natural anti-α-galactosyl immunoglobulin G and bacteria of the human flora. Infect Immun 1988:56:1730.
13. STONE KR, WALGENBACH AW, ABRAMS T, NELSON J, GELLETT N, GALILI U. Porcine and bovine cartilage transplants in cynomolgus monkey: I. A model for chronic xenograft rejection. Transplantation 1997:63:640.
14. GALILI U, LATEMPLE DC, WALGENBACH AW, STONE KR. Porcine and bovine cartilage transplants in cynomolgus monkey: II. Changes in anti-Gal response during chronic rejection. Transplantation 1997:63:646.
15. GALILI U, TIBELL A, SAMUELSSON B, RYDBERG L, GROTH CG. Increased anti-Gal activity in diabetic patients transplanted with fetal porcine islet cell clusters. Transplantation 1995: 59:1549.
16. AVILA JL, ROJAS M, GALILI U. Immunogenic Galα1→ 3Gal carbohydrate epitopes are present on pathogenic American Trypanosoma and Leishmania. J Immunol 1989:142:2828.
17. MINANOV OP, ITESCU S, NEETHLING FA, MORGENTHAU AS, KWIATKOWSKI P, COOPER DKC, MICHLER RE. Anti-Gal IgG antibodies in sera of newborn humans and baboons and its significance in pig xenotransplantation. Transplantation 1997:63:182.
18. GROTH CG, KORGSEN O, TIBELL A, TOLLERMAN J, MöLLER E, BOLINDER J, OSTMAN J, REINHOLT FP, HELLERSTROM C, ANDERSSON A. Transplantation of fetal porcine pancreas to diabetic patients: Biochemical and histological evidence for graft survival. Lancet 1994:344:1402.
19. SATAKE M, KAWAGISHI N, RYDBERG L, SAMUELSSON BE, TIBELL A, GROTH CG, MöLLER E. Limited specificity of xenoantibodies in diabetic patients transplanted with fetal porcine islet cell clusters. Main antibody reactivity against α-linked galactose containing epitopes. Xenotransplantation 1994:1:89.
20. SCHAPHERDER AFM, DAHA MR, TEBULTE MTJW, VANDERWOUDE FJ, GOOZEN HG. Antibody-dependent cell-mediated cytotoxicity against porcine endothelium induced by a majority of human sera. Transplantation 1994: 57:1376.
21. WATIER H, GUILLAUMIN J-M, VALLEE I, THIBAULT G, GRUEL Y, LEBRANCHU Y, BARDOS P. Human NK cell-mediated direct and IgG dependent cytotoxicity against xenogeneic porcine endothelial cells. Transplant Immunol 1996: 4:293.
22. COOKE SP, PEARSON JD, SAVAGE COS. Human IgG xenoreactive antibodies mediate damage to porcine endothelial cells in vitro by both humoral and cellular mechanisms. Transplant Immunol 1997:5:39.
23. WINAND RJ, ANARAKI F, ETIENNE-DECERF J, GALILI U. Xenogeneic TSH like activity of the human natural anti-Gal antibody: Interaction of anti-Gal with porcine thyrocytes and with recombinant human TSH receptors expressed on mouse cells. J Immunol 1993:151:3923.
24. STONER RD, TERRES G. Enhanced antitoxin responses in irradiated mice elicited by complexes of tetanus toxoid and specific antibody. J Immunol 1963:91:761.
25. SERGE D, KAEBERLE ML. The immunologic behavior of baby pigs. I. Production of antibodies in three-week old pigs. J Immunol 1962:89:782.
26. CELIS E, CHANG TW. Antibodies to hepatitis B surface antigen potentiate the response of human T lymphocyte clones to the same antigen. Science 1984:224:297.
27. CELIS E, ABRAHAM KG, MILLER RW. Modulation of the immunological response to hepatitis B virus by antibodies. Hepatology 1987:7:563.