Molecular engineering of materials for bioreactivity

Current Opinion in Solid State and Materials Science

Volumn 4, Issue 4, 1999, Pages 381-387

  Healy, Kevin E ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Northwestern University   (United States)

Author keywords

Bioreactivity; Molecular engineering

Indexed keywords

EID: 0001423076     PISSN: 13590286     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-0286(99)00038-8     Document Type: Article

References (25)

1. Webb K., Hlady V., Tresco P.A. Relative importance of surface wettability and charged functional groups on NIH 3T3 fibroblast attachment, spreading, and cytoskeletal organization. J Biomed Mater Res. 41:1998;422-430.
2. Scotchford C.A., Cooper E., Leggett G.J., Downes S. Growth of human osteoblast-like cells on alkanethiol on gold self-assembled monolayers: the effect of surface chemistry. J Biomed Mater Res. 41:1998;431-442.
3. Jenny C.R., DeFife K.M., Colton E., Anderson J.M. Human monocyte/macrophage adhesion, macrophage motility, and IL-4 induced foreign body giant cell formation on silane-modified surfaces in vitro. J Biomed Mater Res. 41:1998;171-182.
4. Tang L., Liu L., Elwing H.B. Complement activation and inflammation triggered by model biomaterial surfaces. J Biomed Mater Res. 41:1998;333-340.
5. Tong Y.W., Shoichet M.S. Enhancing the interaction of central nervous system neurons with poly(tetrafluoroethylene-co-hexafluoropropylene) via a novel surface amine-functionalization reaction followed by peptide modification. J Biomater Sci, Polymer Edition. 9:1998;713-729. Most papers employing biomimetic engineering have been performed on model materials. This paper demonstrates the use of peptide-modification on a clinically relevant material.
6. Rezania A., Healy K. Biomimetic surface engineering of materials for controlling bone cell adhesion and spreading. Thomson K., Mooney D., Healy K.E., Mikos A. Mat Res Soc Symp Proc, 530 :1998;99-103 Materials Research Society.
7. Rezania A., Thomas C.H., Branger A.B., Waters C.M., Healy K.E. The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone sialoprotein. J Biomed Mater Res. 37:1997;9-19.
8. Xiao S.-J., Textor M., Spencer N.D. Covalent attachment of cell-adhesive, (Arg-Gly-Asp)-containing peptides to titanium surfaces. Langmuir. 14:1998;5507-5516. A thorough paper addressing the covalent attachment of peptides to an inorganic and clinically relevant material (i.e. titanium). Experiments with radiolabeled peptides demonstrated the instability of silane coupling molecules in aqueous environment.
9. Rezania A., Healy K.E. Biomimetic peptide surfaces that regulate adhesion, spreading, cytoskeletal organization, and mineralization of the matrix deposited by osteoblast-like cells. Biotechnol Progr. 15:1999;19-32. This paper demonstrated that a combination of peptides immobilized on the surface can have a synergistic effect on long-term biological events such as mineralization of the matrix synthesized by cultured osteogenic cells.
10. Dee K.C., Anderson T.T., Bizios R. Design and function of novel osteoblast-adhesive peptides for chemical modification of biomaterials. J Biomed Mater Res. 40:1998;371-377.
11. Fujisawa R., Mizuno M., Nodasaka Y., Kuboki Y. Attachment of osteoblastic cells to hydroxyapatite crystals by a synthetic peptide (Glu7-Pro-Arg-Gly-Asp-Thr) containing two functional sequences of bone sialoprotein. Matrix Biol. 16:1997;21-28.
12. Drumheller P.D., Elbert D.L., Hubbell J.A. Multifunctional poly(ethylene glycol) semi-interpenetrating networks as highly selective adhesive substrates for bioadhesive peptide grafting. Biotechnol Bioeng. 43:1994;772-780.
13. Hern D.L., Hubbell J.A. Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J Biomed Mater Res. 39:1998;266-276. A simple synthetic route for incorporating peptides into PEG-based hydrogels was developed and required a spacer arm of critical length for the system to be biologically active.
14. Bearinger J.P., Castner D.G., Healy K.E. Biomolecular modification of p(AAm-co-EG/AA) IPNs supports osteoblast adhesion and phenotypic expression. J Biomater Sci, Polymer Edition. 9:1998;629-652. This manuscript addressed the synthesis of a thin peptide-modified hydrogel coating (~20 nm) that promoted the osteogenic phenotype in environments containing serum proteins.
15. Neff J.A., Caldwell K.D., Tresco P.A. A novel method for surface modification to promote cell attachment to hydrophobic substrates. J Biomed Mater Res. 40:1998;511-519. A simple method, that employs self-assembly, was developed to coat hydrophobic polymer surfaces with peptide-modified block copolymers.
16. Fields G.B., Lauer J.L., Dori Y., Forns P., Yu Y.C., Tirrell M. Protein-like molecular architecture: biomaterial applications for inducing cellular receptor binding and signal transduction. Biopolymers. 47:1998;143-151. This paper describes a simple coating strategy with peptide-amphiphiles that self assemble when physisorbed on hydrophobic polymers. Tissue culture polystyrene coated with these unique molecules led to intracellular signaling dependent on the triple-helical conformation of the peptide-amphiphiles.
17. Josefowicz M., Josefonvicz J. Randomness and biospecificity: random copolymers are capable of biospecific molecular recognition in living systems. Biomaterials. 18:1997;1633-1644.
18. Cansell M., Parisel C., Jozefonvicz J., Letourneur D. Liposomes coated with chemically modified dextran interact with human endothelial cells. J Biomed Mater Res. 44:1999;140-148. This publication demonstrates an important concept, that the active ''biological'' ligand used for interaction with mammalian cells can be a synthetic polymer.
19. Belcheva N., Baldwin S.P., Saltzman W.M. Synthesis and characterization of polymer-(multi)-peptide conjugates for control of specific cell aggregation. J Biomater Sci, Polymer Edition. 9:1998;207-226.
20. Ding Z., Chen G., Hoffman A.S. Unusual properties of thermally sensitive oligomer-enzyme conjugates of poly(N-isopropylacrylamide)-trypsin. J Biomed Mater Res. 39:1998;498-505.
21. Borkenhagen M., Clemence J.-F., Sigritst H., Aebischer P. Three-dimension extracellular matrix engineering in the nervous system. J Biomed Mater Res. 40:1998;392-400. The use of peptide signals in three-dimensional agarose gels to enhance the outgrowth of neurites from dorsal root ganglia was illustrated. The observations made demonstrate the extension of biomimetic engineering to three-dimensional materials and more complex biological systems than isolated cells.
22. Grzesiak J.J., Pierschbacher M.D., Amodeo M.F., Malaney T.I., Glass J.R. Enhancement of cell interactions with collagen/glycosaminoglycan matrices by RGD derivatization. Biomaterials. 18:1997;1625-1632.
23. Tabata Y., Yamada K., Miyamoto S., et al. Bone regeneration by basic fibroblast growth factor complexed with biodegradable hydrogels. Biomaterials. 19:1998;807-815.
24. Compan V., Guzman J., Riande E. A potentiostatic study of oxygen transmissibility and permeability through hydrogel membranes. Biomaterials. 19:1998;2139-2145.
25. West J.L., Hubbell J.A. Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules. 32:1999;241-244. The concept of protease degradable materials was clearly demonstrated in this manuscript. Triblock copolymers (ABA) of PEG (B) with peptide blocks (A) as sites for protease cleavage (e.g. collagenase, plasmin) were synthesized and shown to be degradable based on the specific protease and amino acid cleavage sequence present.