Pharmacokinetics and Biological Effects of Beta Interferon by Intravenous (iv) Bolus Administration in Healthy Volunteers as Compared with iv Infusion

Japanese Journal of Clinical Pharmacology and Therapeutics

Volumn 19, Issue 3, 1988, Pages 625-635

  Hino, Kunihiko ^a   Kondo, Toshiro ^a   Yasuda, Kiyomi ^a   Fukuhara, Akinori ^a   Fujioka, Satoru ^a   Shimoda, Kazumi ^a   Niwa, Hirofumi ^a   Iino, Shiro ^b   Suzuki, Hiroshi ^c  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

2 5 AS activity; healthy volunteer pharmacokinetics; HuIFN ; iv bolus

Indexed keywords

EID: 0001400180     PISSN: 03881601     EISSN: 18828272     Source Type: Journal    
DOI: 10.3999/jscpt.19.625     Document Type: Article

References (4)

1. Greenberg, H. B., Pollarad, R. B., Merigan, T. C. : Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. N. Engl. J. Med., 295 : 517–552 (1976).
2. Kohase, M., Kohno. S., Yamazaki, S. : Potency standardization of human interferon preparations for clinical trials. Kohno, R. and Vilcek, J. (Eds.) : The Clinical Potential of Interferons, Univ. of Tokyo Press, Tokyo, pp. 299–309 (1982).
3. Koyama, Y. : Pharmacokinetics and clinical trials of HuIFN-β in malignant tumors. Kishida, T. (Ed.) : Interferons, Proceedings of the International Synposium on Interferon, Organizing Committee of the International Symposium of Interferons, Oct. 1983, Kyoto, pp. 189–195 (1983).
4. Barouki, F. M., Witter, F. R., Griffin, D. E. : Time course of interferon levels, antiviral state, 2’, 5’-oligoadenylate synthetase and side effects in healthy men. J. Interferon Res., 7 : 29–39 (1987).