An improved procedure for the resolution of (rac)-ethylenebis(tetrahydroindenyl)-titanium derivatives

Journal of Organic Chemistry

Volumn 61, Issue 16, 1996, Pages 5650-5651

  Chin, Bain ^a   Buchwald, Stephen L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001359258     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9519726     Document Type: Article

References (14)

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2. Willoughby, C. A.; Buchwald, S. L. J. Org. Chem. 1993, 58, 7627.
3. Willoughby, C. A.; Buchwald, S. L. J. Am. Chem. Soc. 1994, 116, 8952.
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5. Lee, N. E.; Buchwald, S. L. J. Am. Chem. Soc. 1994, 116, 5985.
6. Broene, R. D.; Buchwald, S. L. J. Am. Chem. Soc. 1993, 115, 12569.
7. Viso, A.; Lee, N. E.; Buchwald, S. L. J. Am. Chem. Soc. 1994, 116, 9373.
8. Carter, M. B.; Schiøtt, B.; Gutiérrez, A.; Buchwald, S. L. J. Am. Chem. Soc. 1994, 116, 11667.
9. (a) Wild, F. R. W. P.; Zsolnai, J.; Huttner, G.; Brintzinger, H. H. J. Organomet. Chem. 1982, 232, 233.
10. (b) Collins, S.; Kuntz, B. A.; Hong, Y. J. Org. Chem. 1989, 54, 4154.
11. 1H NMR spectrum.
12. Schafer, A.; Karl, E.; Zsolnai, L.; Huttner, G.; Brintzinger, H. H. J. Organomet. Chem. 1987, 328, 87.
13. 2) and (R)-2,2′-binaphthol (91% yield, 96% ee by HPLC in MeOH on Chiralpak OT(+) chiral stationary phase). Hydrogenation of 4 with (R,R)-1 as precatalyst yielded (R)-5 in >99% ee.
14. The activation of (S,S)-1 using n-BuLi was carried out at 0 °C.