Liquid ventilation

Current Opinion in Critical Care

Volumn 2, Issue 1, 1996, Pages 60-66

  Lachmann, Burkhard ^a   Verbrugge, Serge ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001313450     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-199602000-00009     Document Type: Article

References (26)

1. Lachmann B: Open up the lung and keep the lung open. Intensive Care Med 1992, 8:319-321.
2. Gommers D, Lachmann B: Surfactant therapy in the adult patient. Curr Opin Crit Care 1995, 1:57-61. This article describes the rationale for treatment of patients with ARDS undergoing exogenous surfactant therapy. Case reports of surfactant replacement therapy in adult patients are presented. Possible reasons for differences in outcome of surfactant therapy are described, eg, surfactant dose, application technique, and compositional differences in surfactant preparations.
3. Tütüncü AS, Lachmann B: Perfluorocarbons as an alternative respiratory medium. In Update in Intensive Care and Emergency Medicine, vol 18. Edited by Vincent JL. Berlin: Springer-Verlag; 1994:549-563. Review on the experimental animal investigations with TLV and PLV, and the clinical experience with TLV.
4. Von Neergaard K: Neue Auffassungen über einen Grundbegriff der Atemmechanik: Die Retraktionskraft der Lunge, abhängig von der Oberflächenspannung in den Alveolen. Z Ges Exp Med 1929, 66:373-394.
5. Faithfull NS: Artificial oxygen carrying substances. Adv Exp Med Biol 1992, 317:55-72.
6. Clark LC, Gollan F: Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science 1966, 152:1755-1756.
7. 2 in the 50 to 80 mm Hg range was significantly lower in the TLV animals as compared with the gas-ventilated animals. After discontinuation of ECLS, all gas-ventilated animals died within 1 hour, whereas all TLV animals demonstrated effective gas exchange for 1 hour.
8. Hirschl RB, Overbeck MC, Parent AP, Hernandez R, Schwartz S, Dosanjh A, Johnson K, Bartlett R: Liquid ventilation provides uniform distribution of perfluorcarbon in the setting of respiratory failure. Surgery 1994, 116:159-68. By means of computed tomographic imaging it is shown that in oleic acid lung injury, during gas ventilation, the dependent lung areas are minimally ventilated whereas the nondependent areas remain well aerated. During TLV, there is a homogeneous distribution of perfluorocarbon in the lungs.
9. Hirschl RB, Merz SI, Montoya JP, Parent A, Wolfson MR, Shaffer TH, Barlett RH: Development and application of a simplified liquid ventilation. Crit Care Med 1995, 23:157-163. This group described the adaption of an ECLS circuit as a time-cycled volume-limited liquid ventilator. They applied TLV with this system to eight healthy cats and four oleic acid lung-injured young sheep on ECLS. They conclude that with this simple adaptation of an existing ECLS circuit TLV can be performed successfully.
10. Fuhrman BP, Paczan PR, DeFrancis M: Perfluorocarbon-associated gas exchange. Crit Care Med 1991, 19:712-722.
11. Tütüncü AS, Faithfull NS, Lachmann B: Intratracheal perfluorocarbon administration combined with artificial ventilation in experimental respiratory distress syndrome: dose-dependent improvement of gas exchange. Crit Care Med 1993, 21:962-969. First experiment with PLV in animals with induced acute respiratory failure. This study showed a dose-related improvement in gas exchange with increasing doses of perfluorocarbon, whereas lung mechanics already improved with low-dose perfluorocarbon.
12. Tütüncü AS, Faithfull NS, Lachmann B: Comparison of ventilatory support with intratracheal perfluorocarbon administration and conventional mechanical ventilation in animals with acute respiratory failure. Am Rev Resp Dis 1993, 148:785-792.
13. Tütüncü AS, Akpir K, Mulder P, Erdmann W, Lachmann B: Intratracheal perfluorocarbon administration as an aid in the ventilatory management of respiratory distress syndrome. Anesthesiology 1993, 79:1083-1093.
14. Houmes RJM, Verbrugge S, Hendrik ER, Lachmann B: Hemodynamic effects of partial liquid ventilation with perflubron in acute lung injury. Intensive Care Med 1995, 21:966-972.
15. Curtis SE, Peek JT, Kelly DR: Partial liquid breathing with perflubron improves arterial oxygenation in acute canine lung injury. J Appl Physiol 1993, 75:2696-2702.
16. Nesti FD, Fuhrman BP, Steinhorn DM, Papo MC, Hernan LJ, Duffy LC, Fisher JE, Leach CL, Paczan PR, Burak BA: Perfluorocarbon-associated gas exchange in gastric aspiration. Crit Care Med 1994, 22:1445-1452. This study shows that PLV with perfluorocarbon might prevent ARDS after aspiration if instituted in the period before the acute inflammatory process is manifest.
17. Smith TM, Steinhorn DM, Thusu K, Fuhrman BP, Dandona P: A liquid perfluorochemical decreases the in vitro production of reactive oxygen species by alveolar macrophages. Crit Care Med 1995, 23:1533-1539. This study shows that after exposure of alveolar macrophages to perfuorocarbon in vitro there is a decreased responsiveness of macrophages to chemical activating stimuli.
18. Colton D, Hirschl RB, Till GO, Johnson KJ, Ichiba S, Plato CC, Bartlett RH: Lung vascular permeability is reduced during partial liquid ventilation (PLV) in the setting of respiratory failure. Am Rev Resp Crit Care Med 1995, 151:A446. This is an abstract, but the results are very promising.
19. 2 can be reduced to values as low as 0.5 without impairment of gas exchange or hemodynamics.
20. Salman NH, Fuhrman BP, Steinhorn DM, Papo MC, Hernan LJ, Leach CL, Fisher JE: Prolonged studies of perfluorocarbon associated gas exchange and of the resumptoin of conventional mechanical ventilation. Crit Care Med 1995, 23:919-924. This study shows that atelectasis may occur during the reconversion of partial liquid ventilation to conventional gas ventilation.
21. 99mTc-DTPA. Crit Care Med, in press.
22. 99mTc-DTPA: effects of surfactant depletion by lung lavage. J Appl Physiol 1987, 62:1611-1614.
23. Tütüncü AS, Lachmann B: Effects of partial liquid ventilation on gas exchange and lung mechanics in healthy animals. Appl Cardiopulm Pathophysiol, in press.
24. Quintel M, Hirschl RB, Roth H, Loose R, Tillmanns R, van Ackem K, Bartlett RH: Assessment of perfluorocarbon (PFC) distribution during partial liquid ventilation (PLV) in the setting of acute respiratory failure [abstract]. Am Rev Resp Crit Care Med 1995, 151:A446.
25. Leach CL, Greenspan JS, Rubenstein SD, Shatter TH, Wolfson MR, Jackson JC, deLemose R, Fuhrman BP, LiquiVent™ Study Group: Partial liquid ventilation with LiquVent™: a pilot safety and efficacy study in premature newborns with severe respiratory distress syndrome (RDS) [Abstract]. Pediatr Res 1995, 37:220A.
26. Hirschl RB, Pranikoff T, Gauger P, Schreiner RJ, Dechert R, Bartlett RH: Liquid ventilation in adults, children, and full-term neonates. Lancet 1995, 346:1201-1202.