Active-Control Comparative Equivalency Monotherapy Trials in Epilepsy: Are They Scientifically Valid?

Epilepsy and Behavior

Volumn 2, Issue 3, 2001, Pages 187-192

  Beydoun, A ^a   Milling, C J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001285517     PISSN: 15255050     EISSN: None     Source Type: Journal    
DOI: 10.1006/ebeh.2001.0198     Document Type: Article

References (10)

1. Brodie M J, Richens A, Yuen A WC. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet. 345:1995;476-479
2. Chadwick D W, Anhut H, Greiner M J, Alexander J, Murry G H, Garofalo E A, Pierce M W. A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures. Neurology. 51:1998;1282-1288
3. Epilepsia. 39:1998;799-803
4. Leber P. Hazards of inference: the active control investigation. Epilepsia. 30:1989;S57-63
5. Chadwick D. Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. Brain. 122:1999;441-448
6. Hauser W A, Rich S S, Lee J R. Risk of recurrent seizures after two unprovoked seizures. N Engl J Med. 338:1998;429-434
7. Shinnar S, Berg A T, O'Dell C, Newstein D, Moshe S L, Hauser W A. Predictors of multiple seizures in a cohort of children prospectively followed from the time of their first unprovoked seizures. Ann Neurol. 48:2000;140-147
8. Neurology. 43:1993;478-483
9. Beydoun A, Sackellares J C, Shu V. Safety and efficacy of divalproex sodium monotherapy in partial epilepsy: a double-blind, concentration-response design clinical trial. Depakote Monotherapy for Partial Seizures Study Group. Neurology. 48:1997;182-188
10. Temple R, Ellenberg S S. Placebo-controlled trials and active-control trials in the evaluation of new treatments: Part 1. Ethical and scientific issues. Ann Intern Med. 133:2000;455-463