Folic Acid Protects against Potato Glycoalkaloid α-Chaconine-Induced Disruption of Frog Embryo Cell Membranes and Developmental Toxicity

Journal of Agricultural and Food Chemistry

Volumn 45, Issue 10, 1997, Pages 3991-3994

  Friedman, Mendel ^a   Burns, Craig F ^b   Butchko, Cathy A ^b   Blankemeyer, James T ^b  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Folic acid; Food safety; Frog embryos; Glycoalkaloids; Membrane potential; Potatoes; Teratogenicity; chaconine

Indexed keywords

ANURA; SOLANUM TUBEROSUM;

EID: 0001276947     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf9702205     Document Type: Article

References (37)

1. Armstrong, R. B.; Ashenfelter, K. O.; Eckhoff, C.; Levin, A. A.; Shapiro, S. S. General reproductive toxicology of retinoids. In The Retinoids: Biology, Chemistry, and Medicine; Sporn, M. B., Roberts, A. B., Goodman, D. S., Eds.; Raven Press: New York, 1994; pp 545-572.
2. ASTM. Standard Guide for Conducting the Frog Embryo Teratogenesis Assay-Xenopus; American Society for Testing and Materials: Philadelphia, PA, 1991; E1439-91.
3. Bantle, J. A.; Fort, D. J.; Rayburn, J. R.; DeYoung, D. J.; Bush, S. F. Further validation of FETAX: evaluation of developmental toxicity of five known mammalian teratogens. Drug Chem. Toxicol. 1990, 13, 267-277.
4. Bantle, J. A.; Dumont, J. N.; Finch, R. A.; Linder, G. Atlas of Abnormalities: A Guide for the Peformance of FETAX; Oklahoma State University Press: Stillwater, OK, 1991.
5. Blankemeyer, J. T.; Stringer, B. K.; Rayburn, J. R.; Bantle, J. A.; Friedman, M. Effect of potato alkaloids on membrane potential of frog embryos. J. Agric. Food Chem. 1992, 40, 2022-2026.
6. Blankemeyer, J. T.; Atherton, R.; Friedman, M. Effect of potato glycoalkaloids α-chaconine and α-solanine on sodium active transport in frog skin. J. Agric. Food Chem. 1995,43, 636-639.
7. Coelho, C. N. D.; Klein, N. W. Methionine and neural tube closure in rat embryos: morphological and biochemical analyses. Teratology 1990, 42, 437-451.
8. Coelho, C. N. D.; Weber, J. A.; Klein, N. W.; Daniels, W. G.; Hoagland, T. A. Whole rat embryos require methionine for neural tube closure when cultured in cow serum. J. Nutr. 1989, 119, 1716-1725.
9. Cravo, M.; Gloria, L.; De Sousa, L. S.; Chaves, P.; Dias Pereira, A.; Quina, M.; Nobre-Leitao, C.; Costa Mira, F. Folate status, DNA methylation and colon cancer risk in inflammatory bowel disease. Clin. Nutr. 1995, 14, 50-53.
10. Ehlers, K.; Elmazar, M. A.; Nau, H. Methionine reduces the valparoic acid-induced spina bifida in mice without altering valparoic acid kinetics. J. Nutr. 1996, 126, 67-75.
11. Fluher, E.; Burnham, V. G.; Loew, L. M. Spectra, membrane binding, and potentiometric responses of new charge shift probes. Biochemistry 1985, 24, 5749-5755.
12. Friedman, M. The Chemistry and Biochemistry of the Sulfhydryl Group in Amino Acids, Peptides, and Proteins; Pergamon Press: Oxford, England, 1973.
13. Friedman, M. Improvement in the safety of foods by SH-containing amino acids and peptides. A review. J. Agric. Food Chem. 1994, 42, 3-20.
14. Friedman, M.; Gumbmann, M. R. Nutritional improvement of legume proteins through disulfide interchange. In Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods; Friedman, M., Ed.; Advances in Experimental Medicine and Biology 199; Plenum Press: New York, 1986; pp 357-390.
15. Friedman, M.; Gumbmann, M. R. Nutritional value and safety of methionine derivatives, isomeric dipeptides, and hydroxy analogs in mice. J. Nutr. 1988, 118, 388-397.
16. Friedman, M.; McDonald, G. M. Potato glycoalkaloids: chemistry, analysis, safety, and plant physiology. Crit. Rev. Plant Sci. 1997, 16, 55-132.
17. Friedman, M.; Rayburn, J. R.; Bantle, J. A. Developmental toxicology of potato alkaloids in the frog embryo teratogenesis assay Xenopus (FETAX). Food Chem. Toxicol. 1991, 29, 537-547.
18. Friedman, M.; Rayburn, J. R.; Bantle, J. A. Structural relationships and developmental toxicity of Solanum alkaloids in the frog embryo teratogenesis assay - Xenopus. J. Agric. Food Chem. 1992, 40, 1617-1624.
19. Friedman, M.; McDonald, G. M.; Haddon, W. F. Kinetics of acid catalyzed hydrolysis of potato glycoalkaloids α-chaco-nine and α-solanine. J. Agric. Food Chem. 1993, 41, 1397-1406.
20. Friedman, M.; Henika, P. R.; Mackey, B. E. Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice. J. Nutr. 1996, 126, 989-999.
21. Gumbmann, M. R.; Friedman, M. Effect of sulfur amino acid supplementation of raw soy flour on the growth and pancreatic weights of rats. J. Nutr. 1987, 117, 1018-1023.
22. Hoffman, R. M. Altered methionine metabolism and unbalanced transmethylation: a possible basis for the dynamic phenotype of cancer. In Absorption and Utilization of Amino Acids; Friedman, M., Ed.; CRC: Boca Raton, FL, 1989; Vol. 3, pp 1-7.
23. James, S. J.; Besnakian, A. G.; Miller, B. J. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res. 1994, 54, 5075-5080.
24. Kim, Y. I.; Pogribny, I. P.; Banakian, A. G.; Miller, J. W.; Selhub, J.; James, S. J.; Mason, J. B. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am. J. Clin. Nutr. 1997, 65, 46-52.
25. Louise, C. B.; Obrig, T. J. Specific interaction of Eschericia coli Shiga-like toxin II with human renal endothelial cells. J. Infect. Dis. 1995, 172, 1397-1401.
26. Mills, J. L.; Scott, J. M.; Kirks, P. N.; McPartlin, J. M.; Conley, M. R.; Weir, D.; Molloy, A. M.; Lee, Y. J. Homocysteine and neural tube defects. J. Nutr. 1996, 126, 756S-760S.
27. Milunski, A. Congenital defects, folic acid, and homeobox genes. Lancet 1996, 348, 419-420.
28. Oakley, G. P.; Adams, M. J.; Dickinson, C. M. More folic acid for everyone, now. J. Nutr. 1996, 126, 751S-755S.
29. Rayburn, J. R.; Bantle, J. A.; Qualls, C. W., Jr.; Friedman, M. Glucose 6-phosphate and NADP protect frog embryos against developmental toxicity induced by α-chaconine. Food Chem. Toxicol. 1995, 33, 1021-1025.
30. Rieder, M. J. Prevention of neural tube defects with periconceptional folic acid. Clin. Perinatol. 1994, 27, 483-503.
31. SAS. SAS Guide for Personal Computers, version 6; SAS Institute: Cary, NC, 1987.
32. Shane, B. Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism. Vitamins Hormones 1989, 45, 263-335.
33. Smolin, L. A.; Benevenga, N. J. Methionine, homocyst(e)ine, cyst(e)ine metabolic interrelationships. In Absorption and Utilization of Amino Acids; Friedman, M., Ed.; CRC: Boca Raton, FL, 1989; Vol. 1, pp 157-187.
34. Uthus, E. O.; Poellot, R. A. Dietary folate affects the response of rats to nickel deprivation. Biol. Trace Elem. Res. 1996, 52, 23-35.
35. Wagner, C. Biochemical role of folate in cellular metabolism. In Folate in Health and Disease; Bailey, L. B., Ed.; Dekker: New York, 1995; pp 23-42.
36. Wagner, C.; Na, H. Alteration of embryonic folate metabolism by valparoic acid during organogenesis: implications for mechanism of teratogenesis. Neurology 1992, 42 (Suppl. 5), 17-24.
37. Young, S. N. The use of diet and dietary components in the study of factors controlling affect in humans: a review. J. Psychiatr. Neurosci. 1993, 18, 235-244.