메뉴 건너뛰기
Tetrahedron Letters
Volumn 30, Issue 35, 1989, Pages 4645-4648
A comparison of acid labile linkage agents for the synthesis of peptide C-terminal amides
Author keywords

[No Author keywords available]
Indexed keywords

EID: 0001275595     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(01)80764-4     Document Type: Article
Times cited : (175)
References (14)
  • 8
    • 84918611991 scopus 로고    scopus 로고
    • 1H NMR spectra consistent with their structures.
  • 10
    • 84918604470 scopus 로고    scopus 로고
    • 2).
  • 11
    • 84918624520 scopus 로고    scopus 로고
    • Although the Fmoc-Val-linker resin derivative of 3 requires about one hour for 〉95% cleavage, this is inconsequential in a practical sense sinc 〉1 hr exposure to the cleavage reagent is routinely performed to assure complete removal of side-chain protecting groups. The practical utility (rate of cleavage) of linkage agents 1 and 2 may be enhanced by the use of additives such as thioanisole to the cleavage reagent (see Funakoshi et al. ibid.)
  • 12
    • 84918640128 scopus 로고    scopus 로고
    • Eledoisin and Neuromedin U-25 have the sequences pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-amide and Phe-Lys-Val-Asp-Glu-Glu-Phe-Gln-Gly-Pro-Ile-Val-Ser-Gln-Asn-Arg-Arg-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-amide respectively.
  • 13
    • 84918650540 scopus 로고    scopus 로고
    • HPLC was performed on a Waters Delta-Pak C-18, 100Å, 5um pore, 0.39×15 cm column with a flow rate of 1.0 ml/min at 30°C. Detection was at 220 nm. A linear gradient elution of 6 to 62% acetonitrile in water containing 0.1% TFA was performed.
  • 14
    • 84918642100 scopus 로고    scopus 로고
    • Eledoisin and Neuromedin U-25 were purchased from Bachem Inc., Torrance, CA.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.