Impact of recombinant DNA technology and molecular modeling on the practice of medicinal chemistry: Structure-activity analysis of opioid ligands

American Journal of Pharmaceutical Education

Volumn 63, Issue 3, 1999, Pages 342-347

  Portoghese, Philip S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001253293     PISSN: 00029459     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

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2. Casy, A.F.and Parfitt, R.T., Opioid Analgesics, Plenum Press; New York NY (1986).
3. Jaffe, J.H. and W.R. Martin in The Pharmacological Basis of Therapeutics, Eighth Ed., (edits. Gilman, A.G., Rail, T.W., Nies, A.S., Taylor, P.), Pergamon Press, New York NY (1990) pp. 510-514.
4. Hughes, J., Smith, T.N., Kosterlitz, H.W., Fothergill, L.A., Morgan, B.A. and Morris, H.R., "Identification of two related pentapeptides from brain with potent opiate agonist activity," Nature, 258, 577-579(1976).
5. Cox, B.M., "Endogenous opioid peptides: A guide to structures and terminology," Life Sci., 31, 1645-1658(1982).
6. Zadina, J.E., Hackler, L., Ge, L.-J. and Kastin, A.J., "A potent and selective endogenous ligand for the Mu-opiate receptor," Nature, 386, 499-502(1997).
7. Bhargava, H., "Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome, and self-administration behavior," Pharmacol. Rev., 46, 293-324(1994).
8. Beckett, A.H. and Casy, A.F., "Synthetic analgesics: Stereochemical considerations," J. Pharm. Pharmacol, 6, 986-1001(1954).
9. (a) Portoghese, P.S., "A new concept on the mode of interaction of narcotic analgesics with receptors," J. Med. Chem., 8, 609-616(1965).
10. (b) Portoghese, P.S., "Stereochemical factors and receptor interactions associated with narcotic analgesics," J. Pharm. Sci., 55, 865-887(1966).