Angiotensin-Converting Enzyme Inhibitors. 2. Perhydroazepin-2-one Derivatives

Journal of Medicinal Chemistry

Volumn 31, Issue 2, 1988, Pages 422-428

  Yanagisawa, Hiroaki ^a   Ishihara, Sadao ^a   Ando, Akiko ^a   Kanazaki, Takuro ^a   Miyamoto, Shuichi ^a   Koike, Hiroyuki ^b   Iijima, Yasuteru ^b   Oizumi, Kiyoshi ^b   Matsushita, Yoichi ^b   Hata, Tadashi ^c  

^a DAIICHI SANKYO CO   (Japan)

^b Biological Research Laboratories   (Japan)

^c Analytical and Metabolic Research Laboratories ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; ENALAPRIL; ENALAPRILAT; HEXAMETHYLENEIMINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOLOGICAL MODEL; BLOOD PRESSURE; ETIOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT; RAT; STRUCTURE ACTIVITY RELATION;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMAL; AZEPINES; BLOOD PRESSURE; MOLECULAR CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0001217240     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00397a027     Document Type: Article

References (18)

1. Petrillo, E. W., Jr.; Ondetti, M. A. Med. Res. Rev. 1982, 2, I.
2. Wyvratt, M. J.; Patchett, A. A. Med. Res. Rev. 1985, 5, 483.
3. Thorsett, E. D.; Harris, E. E.; Aster, S.; Peterson, E. R.; Taub, D.; Patchett, A. A. Biochem. Biophys. Res. Commun. 1983, 111, 166.
4. Thorsett, E. D.; Harris, E. E.; Aster, S. D.; Peterson, E. R.; Patchett, A. A. Pept.: Struct. Fund., Proc. Am. Pept. Symp., 8th, 1983, 1983, 555.
5. Wyvratt, M. J.; Tischler, M. H.; Ikeler, T. J.; Springer, J. P.; Tristram, E. W.; Patchett, A. A. Pept.: Struct. Fund., Proc. Am. Pept. Symp., 8th, 1983 1983, 551.
6. (d) Thorsett, E. D.; Harris, E. E.; Aster, S. D.; Peterson, E. R.; Snyder, J. P.; Springer, J. P.; Hirshfield, J. ; Tristram, E. W.; Patchett, A. A.; Ulm, E. H.; Vassil, T. C. J. Med. Chem. 1986, 29, 251.
7. Yanagisawa, H.; Ishihara, S.; Ando, A.; Kanazaki, T.; Miyamoto, S.; Koike, H.; Iijima, Y.; Oizumi, K.; Matsushita, Y.; Hata, T. J. Med. Chem. 1987, 30, 1984.
8. Nagasawa, M. T.; Elberling, J. A.; Fraser, P. S.; Mizuno, N. S. J. Med. Chem. 1971, 14, 501.
9. Cushman, D. W.; Cheung, H. S.; Sabo, E. F.; Ondetti, M. A. Biochemistry 1977,16, 5484.
10. Enalapril series: Patchett, A. A.; Harris, E.; Tristram, E. W.; Wyvratt, M. J.; Wu, M. T.; Taub, D.; Peterson, E. R.; Ikeler, T. J.; ten Broeke, J.; Paine, L. G.; Ondeyka, D. L.; Thorsett, E. D.; Greenlee, W. J.; Lohr, N. S.; Hoffsommer, R. D.; Joshua, H.; Ruyle, W. V.; Rothrock, J. W.; Aster, S. D.; Maycock, A. L.; Robinson, F. M.; Hirshmann, R.; Sweet, C. S.; Ulm, E. H.; Gross, D. M.; Vassil, T. C.; Stone, C. A. Nature (London) 1980, 288, 280.
11. Attwood, M. R.; Hassall, C. H.; Kröhn, A.; Lawton, G. J. Chem. Soc., Perkin Trans. 1 1986, 1011.
12. Itoh, K.; Kori, M.; Inada, Y.; Nishikawa, K.; Kawamatsu, Y.; Sugihara, H. Chem. Pharm. Bull. 1986, 34, 2078;
13. Nagasawa, M. T.; Elberling, J. A.; Fraser, P. S.; Mizuno, N. S. J. Med. Chem. 1971, 14, 501.
14. Dewar, M. J. S.; Mckee, M. L.; Rzepa, H. S. J. Am. Chem. Soc. 1978, 100, 3607.
15. Andrews, R. P.; Carson, J. M.; Caselli, A.; Spark, M. J.; Woods, R. J. Med. Chem. 1985, 28, 393
16. Papa, D.; Schwenk, E.; Hankin, H. J. Am. Chem. Soc. 1947, 69, 3018.
17. Main, P.; Hull, S. E.; Lessinger, L.; Germin, G.; Declercq, J.-P.; Woolfson, M. MULTAN-78, A System of Computer Programs for the Automatic Solution of Crystal Structuresfrom X-ray Diffraction Data, University of York, England and Louvain, Belgium, 1978
18. Koyama, Y.; Okada, K. Acta Crystallogr., Sect. A: Cryst. Phys., Diffr., Theor. Gen. Crystallogr. 1975, A31, S18.