Synthesis of 3-substituted 4-aroylisoquinolines via Pd-catalyzed carbonylative cyclization of o-(1-Alkynyl)benzaldimines

Organic Letters

Volumn 4, Issue 2, 2002, Pages 193-196

  Dai, Guangxiu ^a   Larock, Richard C ^a  

^a IOWA STATE UNIVERSITY   (United States)

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ARTICLE;

EID: 0001207040     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol010230y     Document Type: Article

References (14)

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8. Tri-n-butylamine and triethylamine afforded the same yields of 2,3, and 4. Tri-n-butylamine was chosen over triethylamine because tri-n-butylamine has a higher boiling point than triethylamine and is less easily lost during the reaction.
9. During our optimization work, we found out that the reactions of substrate 1 and 4-iodoanisole at 80 and 100°C gave the same yields of products 2, 3, and 4, although the reaction at 80°C took a much longer time to complete.
10. Tsuji, J. Palladium Reagents and Catalysts; John Wiley & Sons: Chichester, 1999; p 253.
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