Synthesis of 4-Aryl-3-(2-chromonyl)-2-pyrazolines by the 1,3-Dipolar Cycloaddition of 2-Styrylchromones with Diazomethane

Journal of Heterocyclic Chemistry

Volumn 35, Issue 1, 1998, Pages 217-224

  Pinto, Diana C G A ^a   Silva, Artur M S ^a   Almeida, Lúcia M P M ^a   Cavaleiro, José A S ^a   Lévai, Albert ^b   Patonay, Tamás ^b  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001163474     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570350140     Document Type: Article

References (21)

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13. Although all chiral compounds described in this paper are racemates, owing to a better understanding of the stereochemistry, only one enantiomer is illustrated.
14. The identification H-4 trans and H-4 cis in the case of 2-pyrazolines 4 is to show their stereochemistry relatively to H-3. However, in the case of 1-pyrazolines 5 H-5 trans and H-5 cis is to show their stereochemistry relatively to H-4.
15. J. A. Alexandrova, N. A. Dorofeeva, A. V. Chernova and U. K. Khairullin, Zh. Org. Khim., 14, 1874 (1978).
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21. Diazomethane was bubbled through the flask containing the solution of each 2-styrylchromone 3a-e. The saturation of this solution with diazomethane was complete when another flask, connected to the first one, containing ethyl ether became yellow. Caution. Diazomethane is a highly toxic, explosive gas. See: The Merck Index, Eleventh Edition, Published by Merck and Co., Inc., Rahway, NJ, USA, Compound No. 2983, 1989, p 473.