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Volumn 4, Issue 5, 2002, Pages 523-529

SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis

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ARTICLE;

EID: 0001155919     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc020030t     Document Type: Article
Times cited : (35)

References (45)
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    • note
    • 23 the modification of resin-bound substrates by Friedel-Crafts chemistry had yet to be achieved prior to our study.
  • 10
    • 0003164461 scopus 로고
    • Epton, R., Ed.; SPCC (U.K.) Ltd.: Birmingham, U.K.
    • Rapp, W.; Zhang, L.; Bayer, E. In Solid Phase Synthesis; Epton, R., Ed.; SPCC (U.K.) Ltd.: Birmingham, U.K., 1990; p 205. Meldal, M. Tetrahedron Lett. 1992, 33, 3077-3080.
    • (1990) Solid Phase Synthesis , pp. 205
    • Rapp, W.1    Zhang, L.2    Bayer, E.3
  • 11
    • 0026704473 scopus 로고
    • Rapp, W.; Zhang, L.; Bayer, E. In Solid Phase Synthesis; Epton, R., Ed.; SPCC (U.K.) Ltd.: Birmingham, U.K., 1990; p 205. Meldal, M. Tetrahedron Lett. 1992, 33, 3077-3080.
    • (1992) Tetrahedron Lett. , vol.33 , pp. 3077-3080
    • Meldal, M.1
  • 17
    • 0033575063 scopus 로고    scopus 로고
    • MAS NMR spectroscopy showed that SPOCC resin preparations contained significant levels of resin-trapped para-substituted aromatic impurities that presumably originate from the tosylated oxetane derivatives. Rademann, J.; Grøtli, M.; Meldal, M.; Bock, K. J. Am. Chem. Soc. 1999, 121, 5459-5466.
    • (1999) Am. Chem. Soc. , vol.121 , pp. 5459-5466
    • Rademann, J.1    Grøtli, M.2    Meldal, M.3    Bock, K.J.4
  • 27
    • 0030869479 scopus 로고    scopus 로고
    • Keifer, P. A.; Baltusis, L.; Rice, D. M.; Tymiak, A. A.; Shoolery, J. N. J. Magn. Reson., Ser. A 1996, 119, 65-75. Keifer, P. A. Drug Discovery Today 1997, 2, 468-478. Lindon, J. C.; Nicholson, J. K. Trends Anal. Chem. 1997, 16, 190-200.
    • (1997) Drug Discovery Today , vol.2 , pp. 468-478
    • Keifer, P.A.1
  • 28
    • 0031127873 scopus 로고    scopus 로고
    • Keifer, P. A.; Baltusis, L.; Rice, D. M.; Tymiak, A. A.; Shoolery, J. N. J. Magn. Reson., Ser. A 1996, 119, 65-75. Keifer, P. A. Drug Discovery Today 1997, 2, 468-478. Lindon, J. C.; Nicholson, J. K. Trends Anal. Chem. 1997, 16, 190-200.
    • (1997) Trends Anal. Chem. , vol.16 , pp. 190-200
    • Lindon, J.C.1    Nicholson, J.K.2
  • 30
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    • note
    • (a) The synthesis of several 5-15 residue peptides with 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) and 4-ethylmorpholine (NEM) coupling chemistry in DMF proceeded without evidence of acylation difficulties or aggregation problems.


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