Efficient and Practical Catalytic Oxidation of Alcohols Using Molecular Oxygen

Journal of Organic Chemistry

Volumn 63, Issue 22, 1998, Pages 7576-7577

  Markó, Istvdn E ^a   Gautier, Arnaud ^b   Chellé Regnaut, Isabelle ^c   Giles, Paul R ^a   Tsukazaki, Masao ^b   Urch, Christopher J ^c   Brown, Stephen M ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b JEALOTT S HILL RESEARCH STATION   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001146623     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo980770h     Document Type: Article

References (24)

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16. For an independent report of the same discovery, see: Lenz, R.; Ley, S. V. J. Chem. Soc., Perkin Trans, l 1997,3291. For previous work on the use of CuCl-Phen as a catalyst for the aerobic oxidation of alcohols, see:
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21. One rare exception appears to be KOBu'. For example, the aerobic oxidation of 2-undecanol (5 mol % CuCl·Phen, 5 mol % KOBu', toluene, 80-90 °C) afforded 2-undecanone in almost quantitative yields. However, this system appears, so far, to be limited to secondary alcohol oxidations.
22. For a discussion of the possible mechanism of this reaction, see: Marke, I. E.; Tsukazaki, M.; Giles, P. R.; Brown, S. M.; Urch C. J. Angew. Chem., Int. Ed. Engl. 1997, 36, 2208.
23. 2Cl, DMF, and MeCN).
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