IL-4 signaling mechanisms in Inflammatory Bowel Disease mononuclear phagocytes

Inflammatory Bowel Diseases

Volumn 2, Issue 4, 1996, Pages 244-252

  Rückert, Yvonne ^a   Schindler, Ulrike ^b   Heinig, Thomas ^c   Nikolaus, Susanna ^a   Raedler, Andreas ^c   Schreiber, Stefan ^a,d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b AMGEN INC   (United States)

^c Tabea Hospital   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

IL 4 receptor; Monocytes macrophages; Stat 6

Indexed keywords

EID: 0001113972     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1002/ibd.3780020404     Document Type: Article

References (48)

1. Mahida YR, Wu K, Jewell DP. Enhanced production of interleukin 1-β by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease. Gut 1989;30:835-8.
2. Ligumsky M, Simon PL, Karmeli F, Rachmilewitz D. Role of interleukin 1 in inflammatory bowel disease - enhanced production during active disease. Gut 1990;31:686-9.
3. MacDonald TT, Hutchings P, Choy MY, Murch S, Cooke A. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed intestine. Clin Exp Immunol 1990;81:301-5.
4. Stevens C, Walz G, Singaram C, Lipman ML, Zanker B, Muggia A, Antonioli D, Peppercorn MA, Strom TB. Tumor necrosis factor-α, interleukin-1β and interleukin 6 expression in inflammatory bowel disease. Dig Dis Sci 1992;37:818-26.
5. Isaacs KL, Sartor RB, Haskill S. Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology 1992;103: 1587-95.
6. Reinecker H-C, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott RP, Raedler A. Enhanced secretion of tumor necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993;94:174-81.
7. Essner R, Rhoades K, McBride WH, Morton DL, Esconomou JS. IL-4 down-regulates IL-1 and TNF gene expression in human monocytes. J Immunol 1989;142:3857-61.
8. 2. Proc Natl Acad Sci USA 1989;86:3803-8.
9. Stein M, Keshav S, Harris N, Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992;176:287-92.
10. Te Velde AA, Klomp JP, Yard BA, de Vries JE, Figdor CG. Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4. J Immunol 1988;140:1548-53.
11. Vannier E, Miller LC, Dinarello CA. Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Proc Natl Acad Sci USA 1992;89: 4076-80.
12. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood 1991;77:1627-52.
13. Cominelli F, Kam L, Casiniraggi V, Jin Y, Pizarro TT. Specific mucosal imbalance of IL-1 and IL-1 receptor antagonist in IBD - a potential mechanism of chronic inflammation. Gastroenterology 1994;106:A667.
14. Winston LA, Hunter T. Intracellular signalling: putting JAKs on the kinase MAP. Curr Biol 1996;6:668-71.
15. IhIe JN. STAT's: signal transducers and activators of transcription. Cell 1996;84:331-4.
16. Hassanain HH, Dai W, Gupta SL. Enhanced gel mobility shift assay for DNA-binding factors. Analyt Biochem 1993;213:162-7.
17. Seitz M, Loetscher P, Dewald B, Towbin H, Ceska M, Baggiolini M. Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins and prostaglandin E by rheumatoid and osteoarthritic synoviocytes - regulation by IFN-gamma and IL-4. J Immunol 1994;152:2060-5.
18. Wirth JJ, Kierszenbaum F, Zlotnik A. Effects of IL-4 on macrophage functions: increased uptake and killing of a protozoan parasite (Trypanosoma cruzi). Immunology 1989;66:296-301.
19. Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffmann RL. Inhibition of TH1 responses prevents inflammatory bowel disease in SCID mice reconstituted with CD45RB(high) CD4 T cells. Immunity 1994;1:553-62.
20. Schreiber S, Heinig T, Panzer U, Reinking R, Bouchard A, Stahl PD, Raedler A. Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease. Gastroenterology 1995;108:21-3.
21. Kucharzik T, Lügering N, Weigelt H, Adolf M, Domschke W, Stoll R. Comparison of the suppressive effects of interleukin-13, interleukin-10, and interleukin-4 on blood monocytes from patients with IBD [Abstract]. Gastroenterology 1996;110:A943.
22. Fukushima K, West GA, Klein JS, Levine AD, Fiocchi C. Opposite modulatory activity of IL-10 and IL-4 on lamina propria mononuclear cells (LpMC) is stimulus-dependent [Abstract]. Gastroenterology 1993;104:A702.
23. Matsuura T, West GA, Klein JS, Levine AD, Kusugami K, Morise K, Fiocchi C. Immune activation gene products are resistant to IL-4 inhibitory activity in Crohn's disease (CD) [Abstract]. Gastroenterology 1993;104:A739.
24. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968;23:31-42.
25. Chromczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
26. Wang AM, Doyle MV, Mark DF. Quantitation of mRNA by the polymerase chain reaction. Proc Natl Acad Sci USA 1989;86: 9717-21.
27. Schreiber S, Heinig T, Thiele HG, Raedler A. Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995;108:1434-44.
28. Konish M, Sheperd V, Hold G, Stahl P. Uptake of glycoproteins and glycoconjugates by macrophages. Methods Enzymol 1983;98: 301-4.
29. Schreiber S, Blum JS, Chappel JC, Stenson WF, Stahl PD, Teitelbaum SL, Perkins SL. Prostaglandin E specifically upregulates the expression of the mannose-receptor on mouse bone marrow-derived macrophages. Cell Reg 1990;1:403-13.
30. Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci 1949;51:660-72.
31. Osborn L, Kunkel S, Nabel GJ. Tumor necrosis factor and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kb. Proc Natl Acad Sci USA 1989; 86:2335-40.
32. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. An interleukin-4-induced transcription factor: IL-4 Stat. Science 1994;265:1701-6.
33. Sambrook J, Fritsch EF, Maniatis T, eds. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, 1989.
34. Schindler U, Wu P, Rothe M, Brasseur M, McKnight SL. Components of a Stat recognition code: Evidence for two layers of molecular selectivity. Immunity 1995;2:1-20.
35. Sachs L. Angewandte Statistik, 7th ed. Heidelberg, New York, and Tokyo: Springer, 1992.
36. De Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209-20.
37. De Waal Malefyt R, Yssel H, Roncarolo MG, Spits H, de Vries JE. Interleukin-10. Curr Opin Immunol 1992;4:314-20.
38. Ihle JN, Kerr IM. Jaks and Stats in signaling by the cytokine receptor superfamily. TIG 1995;11:69-74.
39. Schindler C, Darnell JE. Transcriptional responses to polypeptide ligands - the Jak-Stat pathway. Annu Rev Biochem 1995;64:621-51.
40. Wang P, Wu P, Siegel MI, Egan RW, Billah MM. Interleukin (IL)-10 inhibits nuclear factor κB (NF-κB) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem 1995;270:9558-63.
41. Kanety H, Feinstein R, Papa MZ, Hemi R, Karasik A. Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1): possible mechanism for suppression of insulin-stimulated phosphorylation of IRS-1. J Biol Chem 1995;270: 23780-4.
42. Quentmeier H, Kolsdorf K, Zaborski M, Drexler HG. IL-4R α and γ chain expression in LPS- and IL-4-stimulated MONO-Mac-6 cells. Leukemia 1995;9:336-40.
43. Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL, Gossum AV, Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives, Orhoim M, Bonaiti-Pellie C, Weissenbach J, Mathew CG, Lennard-Jones JE, Cortot A, Colombel JF, Thomas G. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 1996;379: 821-3.
44. Karttunnen R, Breese EJ, Walker-Smith JA, MacDonald TT. Decreased mucosal interleukin-4 production in gut inflammation. J Clin Pathol 1994;47:1015-8.
45. West GA, Matsuura T, Levine AD, Klein JS, Fiocchi C. Interleukin 4 in inflammatory bowel and mucosal immune reactivity. Gastroenterology 1996;110:1683-95.
46. Welham MJ, Learmonth L, Bone H, Schrader JW. Interleukin-13 signal transduction in lymphohemopoietic cells: similarities and differences in signal transduction with interleukin-4 and insulin. J Biol Chem 1995;270:12286-96.
47. Keegan AD, Johnston JA, Tortolani PJ, McReynolds LJ, Kinzer C, O'Shea JJ, Paul WE. Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of janus kinase activation. Proc Natl Acad Sci USA 1995;92:7681-5.
48. Cosentino G, Soprana E, Thienes CP, Siccardi AG, Viale G, Vercelli D. IL-13 down-regulates CD14 expression and TNF-alpha secretion in normal monocytes. J Immunol 1995;155:3145-51.