Synthesis and central nervous system depressant effects of N3- substituted 2',3'-O-isopropylideneuridines

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 12, 1999, Pages 1802-1804

  Yao, Che Shun ^a,d   Kimura, Toshiyuki ^a   Watanabe, Kazuhito ^a   Kondo, Shigemi ^b   Ho, Ing Kang ^c   Yamamoto, Ikuo ^a  

^a HOKURIKU UNIVERSITY   (Japan)

^b Central Research Laboratory of Nissui Pharmaceutical Co Ltd   (Japan)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^d SOOCHOW UNIVERSITY   (China)

Author keywords

2',Y O isopropylideneuridine; Central nervous system depressant; Hypnotic activity; N3 substituted nucleoside; Sleep prolongation; Spontaneous activity

Indexed keywords

3 N PROPYL 2',3' O ISOPROPYLIDENEURIDINE; PENTOBARBITAL; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG SYNTHESIS; HYPNOSIS; MALE; NONHUMAN; SEDATION; SLEEP;

EID: 0001072435     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.1802     Document Type: Article

References (14)

1. Yamamoto I., Kimura T., Tateoka Y., Watanabe K., Ho I. K, Chem. Pharm. Bull., 33, 4088-4090 (1985).
2. Yamamolo I., Kimura T., Tateoka Y., Watanabe K., Ho I. K, Res. Commun. Chem. Pathol. Pharmacol., 52, 321-332 (1986).
3. Yamamoto I., Kimura T., Tateoka Y., Watanabe K., Ho I. K, J. Med. Chem., 30, 2227-2231 (1987).
4. Koshigami M., Watanabe K., Kimura T., Yamamoto I., Chem. Pharm. Bull., 39, 2597-2599 (1991).
5. Kimura T., Watanabe K., Tateoka Y., Kondo S., Ho I. K., Yamamoto I., Chem. Pharm. Bull., 41, 1180-1182 (1993).
6. Yamamoto I., Kuze J., Kimura T., Watanabe K., Kondo S., Ho I. K., Biol. Pharm. Bull., 17, 514-516 (1994).
7. Kimura T., Kuze J., Teraoka S., Watanabe K., Tateoka Y., Kondo S., Ho I. K., Yamamoto I., Biol. Pharm. Bull., 19, 142-145 (1996).
8. Sasaki T., Minamoto K., Suzuki H., J. Org. Chem., 38, 598-607 (1973).
9. Haley T. J., McCormick W. G., Br. J. Pharmacol., 12, 12-15 (1957).
10. Krooth R. S., Hsiao W. L., Lam G. F. M., J. Pharmacol. Exp. Ther., 207, 504-514 (1978).
11. Komoda Y., Ishikawa M., Nagasaki H., Iriki M., Honda K., Inoue S., Higashi A., Uchizono K., Biomed. Res., 4, 223 228 (1983).
12. Inoue S., Honda K., Komoda Y., Uchizono K., Ueno R., Hayaishi O., Proc. Natl. Acad. Sci. U.S.A., 81, 6240-6244 (1984).
13. Guarneri P., Guarneri R., Mocciaro C., Piccoli F., Neurochem. Res., 8, 1537-1545 (1983).
14. Kimura T., Kuze J., Watanabe K., Kondo S., Ho I. K., Yamamoto I., Eur. J. Pharmacol., 311, 265-269 (1996).