An Evaluation of the Proposed OECD Testing Strategy for Skin Corrosion

Alternatives to Laboratory Animals

Volumn 26, Issue 5, 1998, Pages 709-720

  Worth, Andrew P ^a   Fentem, Julia H ^a   Balls, Michael ^a   Botham, Philip A ^b   Gurren, Rodger D ^c   Earl, Lesley K ^d   Esdaile, David J ^e   Liebsch, Manfred ^f  

^a JOINT RESEARCH CENTRE   (Italy)

^b ASTRAZENECA   (United Kingdom)

^c Institute for in Vitro Sciences   (United States)

^d UNILEVER RESEARCH   (United Kingdom)

^e SANOFI   (France)

^f FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Corrosion; In vitro; Physicochemical; Skin; Structure activity relationship; Testing strategy

Indexed keywords

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0001047719     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. OECD (1996). Final Report of the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods, 62 pp. Paris: OECD.
2. OECD (1998) Revised Proposal for the Harmonization of Hazard Classification Based on Skin Irritation/Corrosion, ENV/MC/CHEM/HCL(98)4, 12 pp. Paris: OECD.
3. Botham, P.A., Earl, L.K., Fentem, J.H., Roguet, R. & van de Sandt, J J.M. (1998). Alternative methods for skin irritation testing: the current status. ECVAM Skin Irritation Task Force report 1. ATLA 26, 195-211.
4. Barratt, M.D., Brantom, P.G., Fentem, J H., Gerner, I., Walker, A.P & Worth, A.P. (1998). The ECVAM international validation study on in vitro tests for skin corrosivity. I. Selection and distribution of the test chemicals. Toxicology in Vitro 12, 471-482.
5. Fentem, J.H., Archer, G.E.B , Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Esdaile, D J., Holzhutter, H-G. & Liebsch, M. (1998). The ECVAM international validation study on in vitro tests for skin corrosivity II. Results and evaluation by the Management Team. Toxicology in Vitro 12, 483-524
6. Young, J.R., How, M.J., Walker, A.P. & Worth, W M H (1988) Classification as corrosive or irritant to skin of preparations containing acidic or alkaline substances without testing on animals. Toxicology in Vitro 2, 19-26.
7. OECD (1992) OECD Guidelines for the Testing of Chemicals No. 404: Acute Dermal Irritation/Corrosion, 6 pp. Paris. OECD
8. Young, J R. & How, M.J (1994) Product classification as corrosive or irritant by measuring pH and acid/alkali reserve. In Alternative Methods in Toxicology, Vol. 10, In Vitro Skin Toxicology (ed A Rougier, A M. Goldberg & H.I. Maibach), pp. 23-35. New York Mary Ann Liebert