Epidemiology and mechanisms relating diet to risk of colorectal cancer

Nutrition Research Reviews

Volumn 9, Issue , 1996, Pages 197-239

  Bingham, Sheila A ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); RODENTIA;

EID: 0001038175     PISSN: 09544224     EISSN: None     Source Type: Journal    
DOI: 10.1079/NRR19960012     Document Type: Article

References (302)

1. ATBC (Alpha Tocopherol. Beta Carotene Cancer Prevention Study Group) (1994). The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. New England Journal of Medicine 330, 1029-1035.
2. Anderson, K. E., Conney, A. H. & Kappas, A. (1982). Nutritional influences on chemical biotransformations in humans. Nutrition Reviews 40, 161-171.
3. Änggård, E. (1994). Nitric oxide: mediator, murderer, and medicine. Lancet 343, 1199-1206.
4. Anti, M., Armelao, F , Marra, G., Percesepe, A., Bartoli, G. M., Palozza, P., Parrella, P., Canetta, C., Gentiloni, N., DeVitis, I. & Gasbarrini, G (1994). Effect of different levels of ω3 fatty acids on rectal cell proliferation in patients at high risk for colorectal cancer. Gastroenterology 107, 1709-1718.
5. Anti, M., Marra, G , Armelao, F., Bartoli, G. M., Ficarelli, R., Percesepe, A , de Vitis, I., Maria, G., Sofo, L., Rapaccini, G L. et al. (1992). Effects of ω3 fatty acids on rectal mucosal proliferation in subjects at risk for colon cancer. Gastroenterology 103, 883-889.
6. Archer, M. C., Saul, R. L., Lyang-Ja Lee & Bruce, W. B (1981). Analysis of nitrate, nitrite and nitrosamines in human faeces In Banbury Report 7. Gastrointestinal Cancer, pp. 321-327 [W. R. Bruce, P. Correa, M. Lipkin, S. Tannenbaum and T. D. Wilkins, editors]. New York: Cold Spring Harbor.
7. Armstrong, B. & Doll, R. (1975). Environmental factors and the incidence and mortality from cancer in different countries with special reference to dietary practices. International Journal of Cancer 15, 617-631.
8. Barnes, S., Grubbs, C., Setchell, K. D. R. & Carlson, J. (1990). Soybeans inhibit mammary tumors in models of breast cancer. In Mutagens and Carcinogens in the Diet (Progress in Clinical & Biological Research), pp. 239-253 [M. W. Pariza, H. U. Aeschbacher, J. S. Felton and S. Sato, editors]. New York: Wiley Liss.
9. Barrington, P J., Baker, R. S. U., Truswell, A. S., Bonin, A. M., Ryan, A. J. & Paulin, A. P. (1990). Mutagenicity of basic fractions derived from lamb and beef cooked by common household methods. Food and Chemical Toxicology 28, 141-146.
10. Bartram, H. P., Gostner, A., Scheppach, W., Reddy, B. S., Rao, C. V., Dusel, G., Richter, F. & Kasper, H. (1993). Effects of fish oil on rectal cell proliferation, mucosal fatty acids and prostaglandin E2 release in healthy subjects. Gastroenterology 105, 1317-1322.
11. Bartsch, H. & Montesano, R. (1984). Relevance of nitrosamines to human cancer. Carcinogenesis 5, 1381-1393.
12. Benito, E., Cabeza, E., Moreno, V., Obrador, A. & Bosch, F. X. (1993). Diet and colorectal adenomas: a case-control study in Majorca. International Journal of Cancer 55, 213-219.
13. Bingham, S. A. (1988). Meat, starch and nonstarch polysaccharides and large bowel cancer. American Journal of Clinical Nutrition 48, 762-767.
14. Bingham, S. A. (1990a). Mechanisms and experimental epidemiological evidence relating dietary fibre (non-starch polysaccharides) and starch to protection against large bowel cancer. Proceedings of the Nutrition Society 49, 153-171.
15. Bingham, S. A. (1990e). Diet and large bowel cancer. Journal of the Royal Society of Medicine 83, 420-422.
16. Bingham, S. A. & Cummings, J. H. (1989). Effect of exercise and physical fitness on large intestinal function. Gastroenterology 97, 1389-1399.
17. Bingham, S. A., Pignatelli, B., Pollock, J., Ellul, A., Mallaveille, C , Gross, G., Runswick, S., Cummings, J. H. & O'Neill, I. K. (1996). Does increased formation of endogenous N nitroso compounds in the human colon explain the association between red meat and colon cancer? Carcinogenesis 17, 515-523.
18. Bingham, S. A., Williams, D. R. R., Cole, T. J. & James, W. P. T. (1979). Dietary fibre and regional large bowel cancer mortality in Britain. British Journal of Cancer 40, 456-463.
19. Bingham, S. A., Williams, D. R. R. & Cummings, J. H. (1985). Dietary fibre consumption in Britain: new estimates and their relation to large bowel cancer mortality. British Journal of Cancer 52, 399-402.
20. Bodmer, W. F., Bailey, C. J., Bodmer, J., Bussey, H. J. R., Ellis, A., Gorman, R., Lucibello, C. F., Murday, V. A., Rider, S. H., Scambler, P., Sheer, D., Solomon, E. & Spurr, N. K. (1987). Localisation of the gene for familial adenomatous polyposis on chromosome 5. Nature 328, 614-616.
21. Boffa, L. C., Lupton, J. R., Mariani, M. R., Ceppi, M., Newmark, H. L., Scalmati, A. & Lipkin, M. (1992). Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats. Cancer Research 52, 5906-5912.
22. Bogaards, J. J. P., Verhagen, H., Willems, M. I., van Poppel, G. & van Bladeren, P. J. (1994). Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma. Carcinogenesis 15, 1073-1075.
23. Boing, L., Martinez, R., Beyme, F. R. & Oltersdorf, F. U. (1985). Regional nutritional patterns and cancer mortality in the Federal Republic of Germany. Nutrition and Cancer 7, 121-130.
24. Bone, E., Tamm, A. & Hill, M. (1976). The production of urinary phenols by gut bacteria and their possible role in the causation of large bowel cancer. American Journal of Clinical Nutrition 29, 1448-1454.
25. Bos, J. L. (1989). ras Oncogenes in human cancer: a review. Cancer Research 49, 4682-4689.
26. Bostick, R. M., Fosdick, L., Wood, J. R., Grambsch, P., Grandits, G. A., Lillemoe, T. J., Louis, T. A. & Potter, J. D. (1995). Calcium and colorectal epithelial cell proliferation in sporadic adenoma patients: a randomized, double-blinded, placebo-controlled clinical trial. Journal of the National Cancer Institute 87, 1307-1315.
27. Bostick, R. M., Potter, J. D., Kushi, L. H., Sellers, T. A., Steinmetz, K. A., McKenzie, D. R., Gapstyr, S. M. & Folsom, A R. (1994). Sugar, meat, and fat intake and non-dietary risk factors for colon cancer incidence in Iowa women. Cancer Causes and Control 5, 38-52.
28. Bostick, R. M., Potter, J. D., Sellers, T. A., McKenzie, D. R., Kushi, L. H. & Folsom, A. R. (1993). Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women - the Iowa Women's Health study. American Journal of Epidemiology 137, 1302-1317.
29. Boyle, P., Kevi, R., Lucchuni, F. & La Vecchia, C. (1993). Trends in diet-related cancers in Japan: a conundrum? Lancet 342, 752.
30. Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, Lipford, J., Lindblom, A. et al. (1994). Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368, 258-261.
31. Burkitt, D. P. (1969). Related disease-related cause? Lancet ii, 1229-1231
32. Butterworth, C. E., Hatch, K. D., Gore, H., Mueller, H. & Krumdieck, C. L. (1982). Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. American Journal of Clinical Nutrition 35, 73-82.
33. Caderni, G., Bianchini, F., Dolora, P. & Kriebel, D. (1989). Proliferative activity in the colon of the mouse and its modulation by dietary starch, fat, and cellulose. Cancer Research 49, 1655-1659.
34. Calmels, S., Ohshima, H., Vincent, P., Gounot, A.-M. & Bartsch, H. (1985). Screening of microorganisms for nitrosation catalysis at pH 7 and kinetic studies on nitrosamine formation from secondary amines by E. coli strains. Carcinogenesis 6, 911-915.
35. Canzian, F., Ushijama, T., Serikawa, T., Wakabayashi, K., Sugimura, T. & Nagao, M. (1994). Instability of microsatellites in rat colon tumours induced by HAA. Cancer Research 54, 6315-6317.
36. Cassidy, A., Bingham, S. A. & Cummings, J. H. (1994). Starch intake and colorectal cancer risk: an international comparison. British Journal of Cancer 69, 937-942.
37. Chacko, A. & Cummings, J. H. (1988). Nitrogen losses from the human small bowel: obligatory losses and the effect of physical form of food. Gut 29, 809-815.
38. Clinton, S. K., Destree, R. J., Anderson, C. R., Truex, P. B., Imrey, P. B. & Visek, W. J. (1979). DMH induced intestinal cancer in rats fed beef or soy bean protein. Nutrition Reports International 20, 335-342.
39. Clinton, S. K., Imrey, P. B., Mangian, H. J., Nandkumar, S. & Visek, W. J. (1992). The combined effects of dietary fat, protein and energy intake on azoxymethane-induced intestinal and renal carcinogenesis. Cancer Research 52, 857-865.
40. Corpet, D. E., Bellier, R., Petrowitsch, S. & Vigouroux, Y. (1994). Digestion and fermentation of proteins in rats fed keratin, albumin, cooked casein and antibiotics. Reproduction, Nutrition, Development 34, 57-64.
41. Corpet, D. E., Stamp, D., Medline, A., Minkin, S., Archer, M. C. & Bruce, W. R. (1990). Promotion of colonic microadenoma growth in mice and rats fed cooked sugar or cooked casein and fat. Cancer Research 53, 6955-6958.
42. Cravo, M., Fidalgo, P., Pereira, A. D., Gouveia Oliveira, A., Chaves, P., Selhub, J., Mason, J. B., Mira, F. C. & Leitao, C. N. I. (1994). DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. European Journal of Cancer Prevention 3, 473-479.
43. Cravo, M. L., Mason, J B., Dayal, Y., Hutchinson, M., Smith, D., Selhub, J. & Rosenberg, I. H. (1992). Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Research 52, 5002-5006.
44. Cummings, J. H. (1981a). Dietary fibre and large bowel cancer. Proceedings of the Nutrition Society 40, 7-14.
45. Cummings, J. H. (1981b). Short chain fatty acids in the human colon. Gut 22, 763-779.
46. Cummings, J. H., Bingham, S. A., Heaton, K. W. & Eastwood, M. A. (1992). Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber). Gastroenterology 103, 1783-1789.
47. Cummings, J. H., Hill, M. J., Bone, E. S., Branch, W. J. & Jenkins, D. J. A. (1979). The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in faeces and urine. American Journal of Clinical Nutrition 32, 2094-2101.
48. Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P. E & Macfarlane, G. T. (1987). Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28, 1221-1227.
49. Cummings, J. H., Stephen, A. M & Branch, W. J. (1981). Implications of dietary fibre breakdown in the human colon. In Banbury Report 7: Gastrointestinal Cancer, pp. 71-81 [W. R. Bruce, P. Correa, M. Lipkin, S. Tannenbaum and T. D. Wilkins, editors]. New York: Cold Spring Harbor
50. Cummings, J. H., Wiggins, H. S., Jenkins, D. J. A., Houston, H., Jivraj, T., Drasar, B. S. & Hill, M. J. (1978). Influence of diets high and low in animal fat on bowel habit, gastrointestinal transit time, fecal microflora. bile acid and fat excretion. Journal of Clinical Investigation 61, 953-963.
51. Decosse, J. J., Miller, H H. & Lesser, M. L. (1989). Effect of wheat fibre and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis. Journal of the National Cancer Institute 81, 1290-1297.
52. De Kok, T. M. C. M., Pachen, D., Van Iersel, M. L. P. S., Baeten, C. G. M. I., Engels, L. G. J. B., ten Hoor, F. & Kleinjans, J. C S. (1993). Case control study on fecapentaene excretion in adenomatous polyps in the colon and rectum. Journal of the National Cancer Institute 85, 1241-1244.
53. Department of Health (1991). Dietary Reference Values for Food Energy and Nutrients for the United Kingdom (Report on Health and Social Subjects no. 41). London: HMSO.
54. Deschner, E. E., Ruperto, J. F , Lupton, J. R. & Newmark, H. L. (1990). Butyrate (tributyrin) does not enhance AOM-induced colon tumorigenesis. Cancer Letters 52, 79-82.
55. Deschner, E. E., Ruperto, J., Wong, G. & Newmark, H. L. (1991). Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 12, 1193-1196.
56. Deschner, E. E., Ruperto, J. F., Wong, G. Y & Newmark, H. L. (1993). The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high fat-diet. Nutrition and Cancer 20, 199-204.
57. Doll, R., Forman, D., La Vecchia, C. & Woutersen, R (1993). Alcoholic beverages and cancers of the digestive tract. In Health Issues Related to Alcohol Consumption, pp. 125-166 [P. M. Verschuren, editor]. Brussels: ILSI.
58. Drasar, B. S. & Irving, D. (1973). Environmental factors and cancer of the colon and breast. British Journal of Cancer 27, 167-172.
59. Eisenbrand, G & Tang, W. (1993) Food borne heterocyclic amines. Chemistry, formation, occurrence and biological activities. A literature review. Toxicology 84, 1-82.
60. Englyst, H. N., Hay, S. & Macfarlane, G. T. (1987). Polysaccharide breakdown by mixed populations of human faecal bacteria. FEMS Microbiology Ecology 45, 163-171.
61. Englyst, H. N., Kingman, S. M. & Cummings, J. H. (1992). Classification and measurement of nutritionally important starch fractions. European Journal of Clinical Nutrition 46 (Suppl. 2), S33-S50.
62. Fearon, E. R. & Vogelstein, B. (1990). A genetic model for colorectal tumorigenesis. Review. Cell 61, 759-767.
63. Feingold, S. M., Sugger, V. L. & Mathisen, G. E. (1983). Normal indigenous intestinal flora. In Intestinal Flora in Health and Disease, pp 3-31 [D. J. Hentges, editor]. New York: Academic Press.
64. Fenwick, G. R., Heaney, R. K. & Mullin, W. J. (1982). Glucosinolates and their breakdown products in food and food plants. CRC Critical Reviews in Food Science and Nutrition 18, 123-201.
65. Freeman, H. J (1986). Effects of differing concentrations of sodium butyrate in 1,2-dimethylhydrazine induced rat intestinal neoplasia. Gastroenterology 91, 596-602.
66. Frentzel-Beyme, R. & Chang-Claude, J. (1994). Vegetarian diets and colon cancer - the German experience. American Journal of Clinical Nutrition 59, 1143S-1152S.
67. Friedenreich, C. M., Howe, G. R. & Miller, A. B. (1991). The effect of recall bias on the association of calorie providing nutrients and breast cancer. Epidemiology 2, 424-429.
68. Friedenreich, C. M., Slimani, N. & Riboli, E. (1992). Measurement of past diet: review of previous and proposed methods. Epidemiologic Reviews 14, 177-196.
69. Friend, S. (1994). A glimpse at the puppet behind the shadow play. Science 265, 334-335.
70. 32P postlabelling. Chemical Research in Toxicology 7, 733-739.
71. Garg, M. L. & Haerdi, J. C. (1993). The biosynthesis and functions of plasmalogens. Journal of Clinical Biochemistry and Nutrition 14, 71-82.
72. Garland, C. F., Comstock, G. W., Garland, F. C., Helsing, K. J., Shaw, E. K. & Gorham, E. D. (1989). Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet ii, 1176-1178.
73. Garland, C., Shekelle, R. B., Barrett-Connor, E., Criqui, M. H., Rossof, A. H. & Paul, O. (1985). Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet i, 307-309.
74. Gerhardsson de Verdier, M., Steineck, G., Hagman, U., Rieger, A. & Norell, S E. (1990). Physical activity and colon cancer: a case reference study in Stockholm. International Journal of Cancer 46, 985-989.
75. Gibson, G. R., Macfarlane, G. T. & Cummings, J. H. (1988). Occurrence of sulphate-reducing bacteria in human faeces and the relationship of dissimilatory sulphate reduction to methanogenesis in the large gut. Journal of Applied Bacteriology 65, 103-111.
76. Gibson, J. A., Sladen, G. E. & Dawson, A. M. (1976). Protein absorption and ammonia production: effects of dietary protein and removal of colon. British Journal of Nutrition 35, 61-65.
77. Giovannucci, E., Rimm, E. B., Stampfer, M. J., Colditz, G. A., Ascherio, A. & Willett, W. C. (1994). Intake of fat, meat, and fiber in relation to risk of colon cancer in men. Cancer Research 54, 2390-2397.
78. Giovannucci, E., Stampfer, M. J., Colditz, G. A , Manson, J. E., Rosner, B A., Longnecker, M., Speizer, F. E. & Willett, W. C. (1993a), A comparison of prospective and retrospective assessments of diet in the study of breast cancer. American Journal of Epidemiology 137, 502-511.
79. Giovannucci, E., Stampfer, M. J., Colditz, G. A., Rimm, E. B., Trichopoulos, D., Rosner, B. A., Speizer, F. E. & Willett, W. C. (1993b). Folate, methionine, and alcohol intake and risk of colorectal adenoma. Journal of the National Cancer Institute 85, 875-884.
80. Giovannucci, E., Stampfer, M. J., Colditz, G., Rimm, E. B. & Willett, W. C. (1992). Relationship of diet to risk of colorectal adenoma in men. Journal of the National Cancer Institute 84, 91-98.
81. Goldbohm, A., Hertog, M. G. L., Brants, H. A. M., van Poppel, G. & van den Brandt, G. (1996). Consumption of black tea and cancer risk: a prospective cohort study. Journal of the National Cancer Institute 88, 93-100.
82. Goldbohm, R. A., van den Brandt, P. A., van't Veer, P., Brants, H. A. M., Dorant, E., Sturmans, F. & Hermus, R. J. J. (1994). A prospective cohort study on the relation between meat consumption and the risk of colon cancer. Cancer Research 54, 718-723.
83. Goldin, B. R., Swenson, L., Dwyer, J , Sexton, M. & Gorbach, S. L. (1980). Effects of diet and Lactobacillus acidophilus supplements on human fecal bacterial enzymes. Journal of the National Cancer Institute 64, 255-261
84. Graf, E. & Eaton, J. W. (1993). Suppression of colonic cancer by dietary phytic acid. Nutrition and Cancer 19, 11-19.
85. Greenberg, E. R., Baron, J. A., Tosteson, T. D., Freeman, D. H., Beck, G. J., Bond, J. H., Colacchio, T. A , Coller, J. A., Frankl, H. D., Haile, R. W et al. (1994). A clinical trial of antioxidant vitamins to prevent colorectal adenoma New England Journal of Medicine 331, 141-147.
86. Gross, G. A (1990). Simple methods for quantifying mutagenic heterocyclic aromatic amines in food products. Carcinogenesis 11, 1597-1603.
87. Guillem, J. G., Obrian, C A., Fitzer, C. J., Johnson, M. D., Forde, K. A , LoGerfo, P. & Weinstein, B. (1987). Studies on protein kinase C and colon carcinogenesis. Archives of Surgery 122, 1475-1478.
88. Gupta, I., Suzuki, K., Bruce, W. R., Krepmski, J. J. & Yates, P. (1984). A model study of fecapentaenes: mutagens of bacterial origin with alkylating properties. Science 225, 521-523.
89. Haenszel, W., Berg, J. W., Segi, M., Kurihara, M. & Locke, F. B. (1973). Large-bowel cancer in Hawaiian Japanese. Journal of the National Cancer Institute 51, 1765-1779.
90. Hague, A., Manning, A. M , Hanlon, K A., Huschtscha, L. I., Hart, D. & Paraskeva, C. (1993). Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway. Implications for the possible role of dietary fibre in the prevention of large-bowel cancer International Journal of Cancer 55, 498-505.
91. Hall, C. N., Badawi, A. F., O'Connor, P. J. & Saffhill, R. (1991). The detection of alkylation damage in the DNA of human gastrointestinal tissues. British Journal of Cancer 64, 59-63.
92. Harris, C. C. (1993). p53 at the crossroads of molecular carcinogenesis and risk assessment Science 262, 1980-1981.
93. Hatch, F. T., Felton, J. S. & Knize, M. G. (1988). Mutagens formed in foods during cooking. ISI atlas of science. Pharmacology 36, 222-228.
94. Havsteen, B. (1983). Flavonoids, a class of natural products of high pharmacological potency. Biochemical Pharmacology 32, 1141-1148.
95. Hayes, J. R., Mgbodile, M. U K., Merrill, A. H., Nerurkar, L. S. & Campbell, T. C. (1978). The effect of dietary protein depletion and repletion on rat hepatic mixed function oxidase activities. Journal of Nutrition 108, 1788-1797.
96. Heilbrun, L. K., Nomura, A., Hankin, J. H. & Stemmermann, G. N. (1989). Diet and colorectal cancer with special reference to fiber intake. International Journal of Cancer 44, 1-6.
97. 12. Journal of the American Medical Association 259, 1525-1530.
98. Hertog, M. G. L., Feskens, E. J. M., Hollman, P. C. H., Katan, M. B. & Kromhout, D. (1993). Dietary antioxidant flavonoids and risk of coronary heart disease - the Zutphen Elderly study. Lancet 343, 1007-1011.
99. Higginson, J. & Oettle, A. G. (1960). Cancer incidence in the Bantu and Cape coloured race of South Africa. Journal of the National Cancer Institute 24, 584-671.
100. Hinzman, M. J., Novotny, C., Ullah, A. & Shamsuddin, A. M. (1987). Fecal mutagen fecapentaene-12 damages mammalian colon epithelial DNA. Carcinogenesis 8, 1475-1479.
101. Hirayama, T. (1981). A large scale cohort study on the relationship between diet and selected cancer of digestive organs. In Banbury Report 7: Gastrointestinal Cancer, pp. 409-429 [W. R. Bruce, P. Correa, M. Lipkin, S Tannenbaum and T. D. Wilkins, editors]. New York: Cold Spring Harbor.
102. Hoensch, H. P., Steinhardt, H. J., Weiss, G., Haug, D., Maier, A. & Malchow, H. (1984). Effects of semisynthetic diets on xenobiotic enzyme metabolizing activity and morphology of small intestinal morphology of humans. Gastroenterology 86, 1519-1530.
103. Hoensch, H., Woo, C. H., Raffin, S. B. & Schmid, R. (1976). Oxidative metabolism of foreign compounds in rat small intestine: cellular localization and dependence on dietary iron. Gastroenterology 70, 1063-1070.
104. Hoff, G., Moen, I. E., Trygg, K., Frølich, W., Sauar, J., Vatn, M., Gjone, E. & Larsen, S. (1986). Epidemiology of polyps in the rectum and sigmoid colon. Evaluation of nutritional factors. Scandinavian Journal of Gastroenterology 21, 199-204.
105. Hollman, P. C. H., de Vries, J. H. M , van Leeuwen, S.D., Mengelers, M. J. B. & Katan, M. B. (1996). Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. American Journal of Clinical Nutrition 62, 1276-12827
106. Hollstein, M., Sidransky, D., Vogelstein, B. & Harris, C. C. (1991). p53 mutations in human cancer. Science 253, 49-53.
107. Howell, M. A. (1975). Diet as an etiological factor in the development of cancers of the colon and rectum. Journal of Chronic Diseases 28, 67-80
108. IARC (International Agency for Research on Cancer) (1982). Large Bowel Cancer Group Second international collaborative study on diet and cancer in Denmark and Finland. Nutrition and Cancer 4, 3-79.
109. IARC (1988). Alcohol Drinking (IARC Monographs no. 44). Lyon: International Agency for Research on Cancer
110. IFT (Institute of Food Technologists) (1993). Potential mechanisms for food-related carcinogens and anticarcinogens. Food Technology 47(2), 105-118.
111. Ito, N., Hasegawa, R., Sano, M., Tamano, S., Esumi, H., Takayama, S. & Sugimura, T. (1991). A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 12, 1503-1506.
112. Iyengar, R., Stuehr, D. J. & Marletta, M. A. (1987). Macrophage synthesis of nitrite, nitrate, and N-nitrosamines. precursors and role of the respiratory burst. Proceedings of the National Academy of Sciences, USA 84, 6369-6373.
113. Jacobs, L R. (1990). Influence of soluble fibres on experimental colon carcinogenesis. In Dietary Fibre, pp. 389-420 [D Kritchevsky, C. Bonfield and J. W. Anderson, editors]. New York: Plenum Press.
114. Jacoby, R. F., Alexander, R. J., Raicht, R. F. & Brasitus, T. A. (1992). K-ras oncogene mutations in rat colon tumours induced by N-methyl-N-nitrosourea. Carcinogenesis 13, 45-49.
115. Jacoby, R. F., Llor, X., Teng, B.-B., Davidson, N. O. & Brasitus, T. A. (1991). Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. Journal of Clinical Investigation 87, 624-630.
116. Jagerstaad, M., Reuterswaerd, A. L., Grivas, S., Olsson, K., Negishi, C. & Sato, S. (1986). Effect of meat composition and cooking conditions on the formation of MelQx and its derivatives. Proceedings of the International Symposium of Prine Takamatsu Cancer Research Fund 1985, pp. 87-96.
117. Johansson, G. K. (1990). Effects of a Shift from a Mixed Diet to a Lactovegetarian Diet. PhD Thesis, Karolinska Institute, Stockholm.
118. Johansson, G. K., Ottova, L. & Gustafsson, J. A. (1990). Shift from a mixed diet to a lactovegetarian diet: influence on some cancer associated intestinal bacterial enzyme activities. Nutrition and Cancer 14, 239-246.
119. Kadlubah, F. F. (1994), Rethinking the role of intestinal microflora in bioactivation of food-borne heterocyclic amine carcinogens. Journal of the National Cancer Institute 86, 5.
120. Kadlubar, F. F., Butler, M. A., Kaderlik, K. R., Chou, H. C. & Lang, N. P. (1992). Polymorphisms for aromatic amine metabolism in humans. Relevance for human carcinogenesis. Environmental Health Perspectives 98, 69-74.
121. Kampman, E., Goldbohm, R. A., van den Brandt, P. A. & van't Veer, P. (1994) Fermented dairy products, calcium, and colorectal cancer in the Netherlands Cohort Study. Cancer Research 54, 3186-3190.
122. Kato, T., Migita, H., Ohgaki, H., Sato, S., Takayama, S. & Sugimura, T. (1989). Induction of tumors in the Zymbal gland, oral cavity, colon, skin and mammary gland of F344 rats by a mutagenic compound, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline. Carcinogenesis 10, 601-603.
123. Keli, S. O., Hertog, M. G. H., Feskens, J. M. & Kroumhout, D. (1996) Dietary flavonoids, antioxidant vitamins and incidence of stroke. Archives of Internal Medicine 156, 637-642.
124. Khan, S. G., Katiyar, S. K., Agarwal, R. & Mukhtar, H. (1992). Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Research 52, 4050-4052.
125. Kim, Y.-I., Christman, J. K., Fleet, J. C., Cravo, M. L., Salomon, R. N., Smith, D., Ordovas, J., Selhub, J. & Mason, J. B. (1995). Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats. American Journal of Clinical Nutrition 61, 1083-1090.
126. Kim, Y. S., Gum, J. R., Ho, S. B. & Deng, G. (1994). In Short Chain Fatty Acids (Falk Symposium 73, 1993) [H. J. Binder, J. Cummings and K. H. Soergel, editors]. Lancaster: Kluwer Academic.
127. Klatsky, A. L., Armstrong, M. A., Freidman, G. D. & Hiatt, R. A. (1988). The relations of alcoholic beverage use to colon and rectal cancer. American Journal of Epidemiology 128, 1007-1015.
128. Kleibeuker, J. H., Welberg, J. W. M., Mulder, N. H., Vandermeer, R., Cats, A., Limburg, A. J., Kreumer, W. M. T., Hardonk, M. J. & De Vries, E. G. E. (1993). Epithelial cell proliferation in the sigmoid colon of patients with adenomatous polyps increases during oral calcium supplementation. British Journal of Cancer 67, 500-503.
129. Klurfeld, D. M. (1990). Insoluble dietary fiber and colon cancer. In Dietary Fiber, pp. 403-416 [D. Kritchevsky, C. Bonfield & J. W. Anderson, editors]. New York: Plenum Press.
130. Knekt, P., Reunanen, A., Takkunene, H., Aromaa, A., Heliovaara, M. & Hakulinene, T. (1989). Body iron stores and risk of cancer. International Journal of Cancer 56, 379-382.
131. Kono, S., Imanishi, K., Shinchi, K. & Yanai, F. (1993). Relationship of diet to small and large adenomas of the sigmoid colon. Japanese Journal of Cancer Research 84, 13-19.
132. Kruh, J. (1982). Effect of sodium butyrate, a new pharmacological agent, on cells in culture. Molecular and Cellular Biochemistry 42, 65-82.
133. Kruh, J., Defer, N. & Tichonicky, L. (1991). Molecular and cellular effects of sodium butyrate. In Report of the 10th Ross Conference on Medical Research, pp. 45-50. Columbus, OH: Ross Laboratories.
134. Kruh, J., Defer, N. & Tichonicky, L. (1994). Effects of butyrate on cell proliferation and gene expression. In Physiological and Clinical Aspects of SCFA, ch. 18 [J. H. Cummings et al editors]. Cambridge: Cambridge University Press.
135. Kubben, F., Engels, L., Arends, J. et al. (1994). The influence of one year calcium supplementation on colorectal epithelial cell proliferation in adenoma patients. In Proceedings of the 10th World Congress of Gastroenterology, Abstract 13.
136. Kuratko, C. & Pence, B. C. (1995). Dietary lipid and iron modify normal colonic mucosa without affecting phospholipase A2 activity. Cancer Letters 95, 181-187.
137. Kuratsune, M., Honda, T., Englyst, H. N. & Cummings, J. H. (1986). Dietary fiber in the Japanese diet as investigated in connection with colon cancer risk. Japanese Journal of Cancer Research 77, 736-738.
138. Laird, P. W., Jackson-Grusby, L., Fazeli, A., Dickinson, S. L., Jung, W. E., Li, E., Weinberg, R. A. & Jaenisch, R. (1995) Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81, 197-205.
139. Lashner, B. A. (1993). Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis. Journal of Cancer Research and Clinical Oncology 119, 549-554.
140. Lashner, B. A., Heidenreich, P. A., Su, G. L., Kane, S. V. & Hanauer, S. B (1989). Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. Gastroenterology 97, 255-259
141. Layton, D. W., Bogen, K. T., Knize, M. G., Hatch, F. T., Johnson, V. M. & Felton, J. S (1995). Cancer risk of heterocyclic amines in cooked foods. Carcinogenesis 16, 39-62.
142. Leaf, A. & Weber, P. C. (1988). Cardiovascular effects of n-3 fatty acids. New England Journal of Medicine 318, 549-557
143. Leaf, C. D., Wishnok, J. S. & Tannenbaum, S. R. (1989). Mechanisms of endogenous nitrosation. Cancer Surveys 8, 323-334.
144. Ling, W. H. & Hänninen, O. (1992). Shifting from a conventional diet to an uncooked vegan diet reversibly alters fecal hydrolytic activities in humans. Journal of Nutrition 122, 924-930.
145. Little, J., Logan, R., Hawtin, P., Hardcastle, J. D. & Turner, I. D. (1991) Colorectal adenomas and dietary fat, protein, fibre and calcium. Gastroenterology 100, A380.
146. Lotfi, A. M., Spencer, R. J., Ilstrup, D. M. & Melton, L. J. (1986). Colorectal polyps and risk of subsequent carcinoma. Mayo Clinic Proceedings 61, 337-343.
147. Longnecker, M. P., Moreno, J. M. M., Knekt, P., Nomura, A. M Y., Schober, S. E., Stahelin, H. B., Wald, N. J., Gey, K. F. & Willett, W. C. (1992). Serum α-tocopherol concentration in relation to subsequent colorectal cancer: pooled data from five cohorts. Journal of the National Cancer Institute 84, 430-435.
148. Longnecker, M. P., Orza, M. J., Adams, M. E. et al. (1990). A meta analysis of alcoholic beverage consumption in relation to colorectal cancer. Cancer Causes and Control 1, 59-68.
149. Loub, W. D., Wattenberg, L. W. & Davis, D. W. (1975). Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants. Journal of the National Cancer Institute 54, 985-988.
150. Lupton, J. R. & Marchant, L. J. (1989). Independent effects of fiber and protein on colonic luminal ammonia concentration. Journal of Nutrition 19, 235-241.
151. McBurney, M. I., Horvath, P. J., Jeraci, J. L. & Van Soest, P. J. (1985). Effect of in vitro fermentation using human faecal inoculum on the water holding capacity of dietary fibre. British Journal of Nutrition 53, 17-24.
152. McConnell, J. B., Murison, J. & Stewart, W. K. (1979). The role of the colon in the pathogenesis of hyperchloraemic acidosis in ureterosigmoid anastomosis. Clinical Science 57, 305-312.
153. Macfarlane, G. T. & Cummings, J. H. (1991). The colonic flora, fermentation, and large bowel digestive function. In The Large Intestine: Physiology, Pathophysiology and Disease, pp. 51-92 [S. F. Phillips, J. H. Pemberton and R. G. Shorter, editors] New York: Raven Press.
154. Macfarlane, G. T., Cummings, J. H. & Allison, C. (1986). Protein degradation by human intestinal bacteria. Journal of General Microbiology 132, 1647-1656.
155. McKeown-Eyssen, G. (1994). Review: triglycerides, glucose and colorectal cancer. Cancer Epidemiology, Biomarkers and Prevention 3, 687-695.
156. McKeown-Eyssen, G. & Bright-See, E (1985). Dietary factors in colon cancer: international relationships. An update. Nutrition and Cancer 7, 251-253.
157. McKeown-Eyssen, G., Holloway, C., Jazmaji, V., Bright-see, E., Dion, P. & Bruce, W. R. (1988). A randomised trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Research 48, 4701-4705.
158. MacLennan, R., Macrae, F., Bain, C., Battistutta, D., Chapuis, P., Gratten, H., Lambert, J., Newland, R. C., Ngu, M., Russell, A., Ward, M. & Wahlqvist, M. L. (1995). Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. Journal of the National Cancer Institute 87, 1760-1766.
159. MacLennan, R., Ward, M., MacRae, F., Wahlqvist, M., Goulston, K., Ngu, M., Battistuta, D. & Gratten, H. (1991). Effect of fat, fiber and beta carotene on occurrence of colorectal adenomas after 24 months Gastroenterology 100, A382.
160. McMichael, A J., McCall, M. G., Hartshorne, J. M. & Woodings, T. L. (1980). Patterns of gastrointestinal cancer in European migrants to Australia - the role of dietary change. International Journal of Cancer 25, 431-437.
161. McMichael, A. J., Potter, J. D. & Hetzel, B. S. (1979). Time trends in colorectal cancer mortality m relation to food and alcohol consumption: United States, United Kingdom, Australia and New Zealand. International Journal of Epidemiology 8, 295-303.
162. MacQuart-Moulin, G., Riboli, E., Cornée, J., Kaaks, R. & Berthezène, P. (1987). Colorectal polyps and diet: a case-control study in Marseilles. International Journal of Cancer 40, 179-188.
163. Mallett, A. K., Rowland, I. R. & Bearne, C. A. (1986). Influence of wheat bran on some reductive and hydrolytic activities of the rat cecal flora. Nutrition and Cancer 8, 125-131.
164. Mallett, A. K , Rowland, I. R., Bearne, C. A., Flynn, J. C., Fehilly, B. J., Udeen, S. & Farthing, M. (1988a). Effects of dietary supplements of apple pectin, wheat bran or fat on the enzyme activity of the human fecal flora. Microbiology and Ecology of Health and Disease 1, 23-29.
165. Mallett, A. K., Walters, D. G. & Rowland, I. R. (1988b). Protein-related differences in the excretion of nitrosoproline and nitrate by the rat - possible modification of de novo nitrate synthesis. Food and Chemical Toxicology 26, 831-835.
166. Margetts, B. (1994). Diet and Cancer: Review of the Epidemiological Literature London: The Nutrition Society.
167. Margison, G. P. & O'Connor, P. J. (1990). Biological consequences of reactions with NDA: role of specific lesions In Handbook of Experimental Pharmacology, vol. 94. pp. 547-571 [C. S. Cooper and P L. Grover, editors], Berlin: Springer.
168. Marnett, L. J. (1992). Aspirin and the potential role of prostaglandins in colon cancer. Cancer Research 52, 5575-5589.
169. Midvedt, T. & Norman, A. M. (1968). Parameters in 7-α dehydroxylation of bile acids by anaerobic bacteria. Acta Pathologica et Microbiologica Scandinavica 72, 313-329.
170. Minowa, M., Bingham, S. & Cummings, J. H. (1983). Dietary fibre intake in Japan. Human Nutrition. Applied Nutrition 37A, 113-119.
171. Morgan, J. W., Frazer, G. F., Phillips, R. L. & Andress, M. H. (1988). Dietary factors and colon cancer incidence among Seventh-Day Adventists. American Journal of Epidemiology 128, 918(A).
172. Morotomi, M., Giullem, J. G , Logerfo, P. & Weinstein, I. B. (1990). Production of diacylglycerol, an activator of protein kinase-C, by human intestinal microflora. Cancer Research 50, 3595-3599.
173. Muir, C., Waterhouse, J., Mack, T., Powell, J. & Whelan, S. (editors) (1987). Cancer Incidence in Five Continents, vol. 5. Lyon: International Agency for Research on Cancer.
174. Mukhtar, H., Wang, Z. Y., Katiyar, S. & Agarwal, R. (1992). Tea components: antimutagenic and anticarcinogenic effects. Preventive Medicine 21, 351-361.
175. Nair, P. P., Shami, S., Sainz, E., Menon, M., Jerabek, L. B., Jones, D. Y., Judd, J. T., Campbell, W. S., Schiffman, M. H., Taylor, P. R., Schatzkin, A., Guidry, C. & Brown, C. C. (1990). Influence of dietary fat on fecal mutagenicity in premenopausal women. International Journal of Cancer 46, 374-377.
176. Narisawa, T. & Fukaura, Y. (1993). A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Japanese Journal of Cancer Research 84, 1007-1009.
177. Narisawa, T., Napoleon, E., Magadia, J. H., Weisburger, J. H. & Wynder, E. L (1974). Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N′-nitro-N-nitrosoguanidine in rats. Journal of the National Cancer Institute 53, 1093-1095.
178. Nelson, R. L., Davis, F. G., Sutter, E., Sobin, L. H., Kikendall, J. W. & Bowen, P. (1994). Body iron stores and risk of colonic neoplasia. Journal of the National Cancer Institute 86, 455-460.
179. Nelson, R. L., Yoo, S. J., Tanure, J. C., Adrianopoulos, G. & Misumi, A. (1989). The effect of iron on experimental colorectal carcinogenesis. Anticancer Research 9, 1477-1482.
180. Neugut, A. I., Grabowski, G. C., Lee, W. C., Murray, T., Nieves, J. W., Forde, K. A., Treat, M. R., Waye, J. D. & Fenogliopreiser, C. (1993). Dietary risk factors for the incidence and recurrence of colorectal adenomatous polyps. A case-control study. Annals of Internal Medicine 118, 91-95.
181. Newmark, H. L., Wargovich, M. J. & Bruce, W. R. (1984). Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. Journal of the National Cancer Institute 72, 1323-1325.
182. Nijhoff, W A., Mulder, T. P., Verhagen, H., van Poppel, G. & Peters, W. H. M. (1995). Effects of consumption of brussels sprouts on plasma and urinary GST in humans. Carcinogenesis 16, 955-957.
183. Nishizuka, Y. (1986). Studies and perspectives of protein kinase C. Science 233, 305-312.
184. Noordhoek, J. & van Bladeren, P. J. (1991). Nutrition and extrahepatic metabolism. In Nutrition, Toxicity and Cancer, pp. 93-112 [I. R. Rowland, editor]. Boca Raton, FL: CRC Press.
185. O'Neill, I. K., Loktionov, A., Manson, M. M., Ball, H., Bandeletova, T. & Bingham, S. A. (1996). Effects of vegetables and teas on the colorectal epithelium and metabolic organs that alter its risk for cancer. Proceedings of the American Association for Cancer Research (in press).
186. O'Neill, I., Ohgaki, H., Ellul, A. & Turesky, R. J. (1992). Entrapment by magnetic microcapsules of the protein pryolysates IQ, PhIP and Glu-P-1, and alteration of IQ metabolite exposure within the rat gastrointestinal tract by risk-modulating components of the human diet. Carcinogenesis 13, 2353-2359.
187. Paganelli, G. M., Biasco, G., Brandi, G., Santucci, R., Gizzi, G., Villani, V., Cianci, M., Miglioli, M. & Barbara, L. (1992) Effect of vitamins A, C, and E supplementation on rectal cell proliferation in patients with colorectal adenomas. Journal of the National Cancer Institute 84, 47-51.
188. Palmer, R. M. J., Ferrige, A. G. & Moncada, S. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526.
189. Parkin, D. M., Muir, C. S., Whelan, S. L., Gao, Y. T., Ferlay, J. & Powell, (1992). Cancer Incidence in Five Comments, vol. 6 (IARC Scientific Publication no. 120). Lyon: International Association for Research on Cancer.
190. Peltomäki, P., Aaltonen, L. A., Sistonen, P., Pylkkänen, L., Mecklin, J.-P., Järvinen, H., Green, J. S., Jaso, J. R., Weber, J. L., Leach, F. S., Petersen, G. M., Hamilton, S R., de la Chapelle, A. & Vogelstein, B (1993). Genetic mapping of a locus predisposing to human colorectal cancer. Science 260, 810-812.
191. Pence, B. C., Buddingh, F. & Yang, S. P. (1986). Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol. Journal of the National Cancer Institute 77, 269-276.
192. Pence, B. P., Butler, M. J., Dunn, D. M., Miller, M. F., Zhao, C. & Landers, M. (1995). Non promoting effects of lean beef in the rat colon carcinogenesis model. Carcinogenesis 16, 1157-1160.
193. Peto, R., Gray, R., Brantom, P & Grasso, P. (1984). Nitrosamine carcinogenicity in 5120 rodents. In Evaluation of Carcinogenic Risk of Chemicals to Humans (IARC Publication no. 57), pp. 627-666 [O'Neill et al. editors]. Lyon: International Association for Research on Cancer.
194. Phillips, J., Muir, J. G., Birkett, A., Lu, Z X., Jones, G. P., O'Dea, K. & Young, G. P. (1995). Effect of resistant starch on fecal bulk and fermentation-dependent events in humans. American Journal of Clinical Nutrition 62, 121-130
195. Phillips, R. L. & Snowdon, D. A. (1985). Dietary relationships with fatal colorectal cancer among Seventh-Day Adventists. Journal of the National Cancer Institute 74, 307-317.
196. Phillips, R. L. & Snowdon, D. A. (1993). Association of meat and coffee use with cancers of the large bowel. Cancer Research 43 (Suppl.) 2403s-2408s.
197. Pilch, S (editor) (1987). Physiological Effects and Health Consequences of Dietary Fiber. Bethesda, MD: FASEB.
198. Porter, J W. G. & Rolls, B. A. (1971). Some aspects of the digestion of proteins. Proceedings of the Nutrition Society 30, 17-25.
199. Potter, J. D., Slattery, M. L., Bostick, R. M. & Gapstur, S. M. (1994). Colon cancer, a review of the epidemiology. Epidemiologic Reviews 15, 489-545.
200. Powles, J. & Williams, D. R. R. (1984). Trends in bowel cancer in selected countries in relation to wartime changes in flour milling. Nutrition and Cancer 6, 40-48.
201. Preussman, R. (1984). Occurrence and exposure to N-nitroso compounds. In Evaluation of Carcinogenic Risk of Chemicals to Humans (IARC Publication no. 57), pp. 3-15 [O'Neill et al editors]. Lyon: International Association for Research on Cancer.
202. Quian, G., Ross, K., Yu, M., Yuan, J., Gao, Y., Henderson, B., Wogan, G. & Groopman, J. (1994). A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiology, Biomarkers and Prevention 3, 3-10.
203. Rafter, J. J., Eng, V. W. S., Furrer, R., Medline, A. & Bruce, W. R. (1986). Effects of calcium and pH on the mucosal damage produced by deoxycholic acid in the rat colon. Gut 27, 1320-1329.
204. Reddy, B. S., Burill, C. & Rigotty, J. (1991). Effects of diets high in ω3 and ω6 fatty acids on initiation and postinitiation stages of colon carcinogenesis. Cancer Research 51, 487-491.
205. Reddy, B. S., Narasawa, T. & Weisburger, J. (1976). Effect of a diet with high levels of protein and fat on colon cacinogenesis in F344 rats treated with 1,2dimethythydrazine. Journal of the National Cancer Institute 57, 567-569.
206. Reddy, B. S., Nayini, J., Tokumo, K., Rigotty, J., Zang, E. & Kelloff, G. (1990). Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-α-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet. Cancer Research 50, 2562-2568.
207. Reddy, B., Rao, C. V. & Rivenson, A. (1993). Aspirin inhibits cancer of the colon. Gastroenterology 104, A443.
208. Reddy, B. S., Sharma, C., Simi, B., Engle, A., Laakso, K., Puska, P. & Korpela, R. (1987). Metabolic epidemiology of colon cancer: effect of dietary fiber on fecal mutagens and bile acids in healthy subjects. Cancer Research 47, 644-648.
209. Reddy, B. S., Simi, B. & Engle, A. (1994). Effect of types of fibre on colonie DAG in women. Gastroenterology 106, 883-889.
210. Reddy, B. & Sugie, S. (1988). Effect of different levels of ω3 and ω6 fatty acids on azoxymethane induced colon carcinogenesis in F344 rats. Cancer Research 48, 6642-6647.
211. Reddy, B. S., Weisburger, J. H. & Wynder, E. L. (1974). Fecal bacterial β-glucuronidase: control by diet. Science 183, 416-417.
212. Rodriguez, J. W., Kirlin, W. G., Ferguson, R. J., Doll, M. A., Gray, K., Rustan, T. D., Lee, M. E., Kemp, K., Urso, P. & Hein, D. W. (1993). Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol. Archives of Toxicology 67, 445-452.
213. Roediger, W. E. W. (1980). Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21, 793-798.
214. Roediger, W. E. W., Duncan, A., Kapaniris, O. & Millard, S. (1993). Reducing sulfur compounds of the colon impair colonocyte nutrition. Implications for ulcerative colitis. Gastroenterology 104, 802-809.
215. Roger, C. R. (1988). The nutritional incidence of flavonoids: some physiological and metabolic considerations Experientia 44, 725-804
216. Rogers, A. E., Zeisel, S. H. & Groopman, J. (1993). Diet and carcinogenesis. Carcinogenesis 14, 2205-2217.
217. Rowland, I. R. (1991). Nutrition and gut flora metabolism. In Nutrition. Toxicity and Cancer, pp. 113-196 [I. R. Rowland, editor]. Boca Raton, FL: CRC Press.
218. Rowland, I. R., Granli, T., Bookman, O. C., Key, P. E. & Massey, R. C. (1991). Endogenous N-nitrosation in man assessed by measurement of apparent total N-nitroso compounds in feces. Carcinogenesis 12, 1395-1401.
219. Rowland, I. R. & Mallett, A. K. (1990). The influence of dietary fibre on the microbial enzyme activity in the gut. In Dietary Fibre, Chemistry, Physiology and Health Effects, pp. 195-206 [D. Kritchevsky, C. Bonfield and J. W. Anderson, editors]. New York: Plenum Press.
220. Rowland, I. R., Mallett, A. K., Bearne, C. A. & Farthing, M. J. G. (1986). Enzyme activities of the hind gut microflora of laboratory animals and man. Xenobiotica 16, 519-523.
221. Rowland, I. R. & Tanaka, R. (1993). The effects of transgalactosylated oligosaccharides on gut flora metabolism in rats associated with a human faecal microflora. Journal of Applied Bacteriology 74, 667-674.
222. Rumney, C. J., Rowland, I. R., Coutts, T. M , Randerath, K., Reddy, R., Shah, A. B., Ellul, A. & O'Neill, I. K. (1993). Effects of risk associated human dietary macrocomponents on processes related to carcinogenesis in human-flora-associated (HFA) rats. Carcinogenesis 14, 79-84.
223. Sandler, R. S., Lyles, C. M., Peipins, L. A., McAuliffe, C. A., Woosley, J. T. & Kupper, L. L. ( 1993). Diet and risk of colorectal adenomas - macronutrients, cholesterol and fiber. Journal of the National Cancer Institute 85, 884-891.
224. Scheppach, W., Burghart, W., Bartram, P. et al. (1990). Addition of dietary fibre to liquid formula diets. Journal of Parenteral and Enteral Nutrition 14, 204-209.
225. Scheppach, W., Fabian, C., Sachs, M. & Kasper, H. (1988). The effect of starch malabsorption on fecal short chain fatty acid excretion in man Scandinavian Journal of Gastroenterology 23, 755-759.
226. Scheppach, W. B., Richter, A., Liepald, H. et al. (1992). Effect of short chain fatty acids on the human colonic mucosa in vitro. Journal of Parenteral and Enteral Nutrition 16, 43-48.
227. Schiffman, M. H. (1987). Diet and faecal genotoxicity. Cancer Surveys 6, 653-672.
228. Schiffman, M. H., Van Tassell, R. L., Robinson, A., Smith, L. et al. (1989). Case control study of colorectal cancer and fecapentaene excretion. Cancer Research 49, 1322-1326.
229. Schofield, P. F. & Jones, D. J. (1992). Colorectal neoplasia I: Benign colonic tumours. British Medical Journal 304, 1498-1500.
230. Segal, I., Walker, A. R. P., Lord, S. & Cummings, J. H. (1988). Breath methane and large bowel cancer risk in contrasting African populations Gut 29, 608-613.
231. Setchell, K. D. R. & Adlercreutz, H. (1988). Mammalian lignans and phytoestrogens. In Role of the Gut Flora in Toxicity and Cancer, pp. 315-345 [I. R. Rowland, editor]. New York: Academic Press.
232. Setchell, K. D. R., Street, J. M. & Sjovall, J. (1987). Fecal bile acids. In The Bile Acids, pp. 441-570 [K. D. R. Setchell, D. Kritchevsky & P. P. Nair, editors]. New York: Plenum Press.
233. Severson, R. K., Nomura, A. M. Y., Grove, J. S. & Stemmermann, G. N. (1989). A prospective analysis of physical activity and cancer. American Journal of Epidemiology 130, 522-529.
234. Shibata, A., Paganini-Hill, A., Ross, R. K., Henderson, R. & Henderson, B. E. (1992). Intake of vegetables, fruits, β-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study. British Journal of Cancer 66, 673-679.
235. Shuker, D. E. G. (1989). Detection of adducts arising from human exposure to N-nitroso compounds. Cancer Surveys 8, 475-487.
236. Silvester, K. R., Bingham, S., Loktionov, A., Cummings, J. & O'Neill, I. (1995). Effect of dietary meat on endogenous N-nitroso compound formation and frequency of k-ras mutants in faecal isolated colonic cells. Proceedings of the Conference on Molecular Aspects of Carcinogenesis, York (in press).
237. Silvester, K. R. & Cummings, J. H. (1995). Does digestibility of meat protein help explain large bowel cancer risk? Nutrition and Cancer 24, 279-288.
238. Sinkeldam, E. J., Kuper, C. F., Bosfand, M. C., Hollanders, V. M. H. & Vedder, D. M. (1990). Interactive effects of dietary wheat bran and lard on N-methyl-N-nitro-N-nitrosoguanidine-induced colon carcinogenesis in rats. Cancer Research 50, 1092-1096.
239. Slattery, M. L., Sorenson, A. W., Mahoney, A. W., French, T. K., Kritchevsky, D. & Street, J. C. (1988). Diet and colon cancer: assessment of risk by fiber type and food source. Journal of the National Cancer Institute 80, 1474-1480.
240. Slob, J. C. M., Lambregts, L. M. C., Schuit, A. J. & Kok, F. J. (1993). Calcium intake and 28-year gastrointestinal cancer mortality in Dutch civil servants. International Journal of Cancer 54, 20-25.
241. Smith, P. J. (1986). n-Butyrate alters chromatin accessibility to DNA repair enzymes. Carcinogenesis 7, 423-429.
242. Solomon, E., Voss, R., Hall, V., Bodmer, W. F., Jaso, J. R., Jeffreys, A. J., Lucibello, F. C., Patel, I. & Rider, S. H. (1987). Chromosome 5 allele loss in human colorectal carcinomas. Nature 328, 616-619.
243. Sonnenberg, A. & Muller, A. (1993). Constipation and cathartics as risk factors in colorectal cancer. Pharmacology 47, 224-233.
244. Sparnins, V. L , Barany, G. & Wattenberg, L. W. (1988). Effects of organosulphur compounds from garlic and onions on benzo[a]pyrene induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis 9, 131-134.
245. Stahelin, H. B., Gey, K. F., Eichholzer, M., Ludin, E., Bernasconi, F., Thurneysen, J. & Brubacher, G. (1991). Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow-up of the prospective Basel study. American Journal of Epidemiology 133, 766-775.
246. Steinbach, G., Kumar, S. P., Reddy, B. S., Lipkin, M. & Holt, P. R. (1993). Effects of caloric restriction and dietary fat on epithelial cell proliferation in rat colon. Cancer Research 53, 2745-2749.
247. Steinmetz, K. A., Kushi, L. H., Bostick, R. M., Folsom, A. R. & Potter, J. D. (1994). Vegetables, fruit and colon cancer in the Iowa Women's health study. American Journal of Epidemiology 139, 1-15.
248. Stemmermann, G N., Heilbrun, L. K. & Nomura, A. M. Y. (1988). Association of diet and other factors with adenomatous polyps of the large bowel: a prospective autopsy study. American Journal of Clinical Nutrition 47, 312-317.
249. Stemmermann, G. N., Nomura, A. M. Y. & Heilbrun, L. K. (1984). Dietary fat and the risk of colorectal cancer. Cancer Research 44, 4633-4637.
250. Stevens, R. G., Graubard, B. I., Micozzi, M. S., Neriishi, K. & Blumberg, B S. (1994). Moderate elevation of body iron level and increased risk of cancer occurrence and death. International Journal of Cancer 56, 364-369.
251. Strange, R. C., Matharoo, B., Faulder, G. C., Jones, P., Cotton, W., Elder, J B. & Deakin, M. (1991). The human glutathione S-transferases: a case-control study of the incidence of the GST1-O phenotype in patients with adenocarcinoma. Carcinogenesis 12, 25-28.
252. Stuehr, D. J. & Marletta, M A. (1985). Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proceedings of the National Academy of Sciences, USA 82, 7738-7742.
253. Sugimura, T. (1986). Past, present, and future of mutagens in cooked foods. Environmental Health Perspectives 67, 5-10.
254. Suzuki, K. & Mitsuoka, T. (1984). N-nitrosamine formation by intestinal bacteria. In Evaluation of Carcinogenic Risk of Chemicals to Humans (IARC Publication no. 57) pp. 275-281 [O'Neill et al. editors]. Lyon: International Association for Research on Cancer.
255. Takahashi, S., Hakoi, K., Yada, H., Hirose, M., Ito, N. & Fukushima, S. (1992) Enhancing effects of diallyl sulphide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulphide on colon and renal carcinogenesis in rats. Carcinogenesis 13, 1513-1518.
256. Takahashi, M , Minamoto, T., Yamashita, N., Yazawa, K., Sugimura, T. & Esumi, H. (1993). Reduction in formation and growth of 1,2-dimethylhydrazine aberrant crypt foci in rat colon by docosahexaenoic acid. Cancer Research 53, 2786-2789.
257. Takayama, S., Nakatsuru, Y., Masuda, M., Ohgaki, H., Sato, S. & Sugimura, T. (1984). Demonstration of the carcinogenicity in F344 rats of 2-amino-3-methylimidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract. Gann 75, 467-470.
258. Talalay, P., Prochaska, H. J. & Spencer, S. R. (1991). Regulation of enzymes that detoxify the electrophilic forms of chemical carcinogens. In Xenobiotics and Cancer, pp. 177-187 [L. Ernster et al., editors]. London: Taylor & Francis.
259. Tank, E. S., Krausch, D N & Lapides, J. (1973). Adenocarcinoma of the colon associated with ureterosigmoidoscopy. Diseases of the Colon and Rectum 16, 300-304.
260. Thind, I. S. (1986). Diet and cancer: an international study. International Journal of Epidemiology 15, 160-163
261. Thun, M. J., Calle, E. E., Namboodiri, M. M., Flanders, W. D., Coates, R. J., Byers, T., Boffetta, P., Garfinkel, L. & Heath, C W. (1992). Risk factors for fatal colon cancer in a large prospective study. Journal of the National Cancer Institute 84, 1491-1500.
262. Tomatis, L., Aitio, A., Day, N. E., Heseltine, E., Kaldor, J., Miller, A. B., Parkin, D. M. & Riboli, E. (editors) (1990). Cancer: Causes, Occurrence and Control (IARC Scientific Publication no. 100). Lyon: International Agency for Research on Cancer.
263. Topping, D. C. & Visek, W. J. (1976). Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine. Journal of Nutrition 106, 1583-1590.
264. Toscani, A., Soprano, D. R. & Soprano, K. J. (1988). Molecular analysis of sodium butyrate induced growth arrest. Oncogene Research 3, 223.
265. Trock, B., Lanza, E. & Greenwald, P. (1990). Dietary fiber, vegetables and colon cancer: critical review and metaanalysis of the epidemiologic evidence. Journal of the National Cancer Institute 82, 650-661.
266. Tsujii, M., Kawano, S., Tsuji, S., Ito, T., Nagano, K., Sasaki, Y., Hayashi, N., Fusamoto, H. & Kamada, T. (1993). Cell kinetics of mucosal atrophy in rat stomach induced by long-term administration of ammonia. Gastroenterology 104, 796-801.
267. Tsujii, M., Kawano, S., Tsuji, S., Nagano, K., Ito, T., Hayashi, N., Fusamoto, H., Kamada, T. & Tamura, K. (1992). Ammonia - a possible promoter in Helicobacter pylori related gastric carcinogenesis. Cancer Letters 65, 15-18.
268. Turesky, R. J., Lang, N. P., Butler, M. A., Teitel, C. H. & Kadlubar, F. F. (1991). Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon. Carcinogenesis 12, 1839-1845.
269. Tuyns, A. F., Kaaks, R. & Haelterman, M. (1987). Colorectal cancer and the consumption of nutrients: a case control study in Belgium. Nutrition and Cancer 10, 181-196.
270. Ullah, A. & Shamsuddin, A. M. (1990). Dose dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats. Carcinogenesis 11, 2219-2222.
271. Van Munster, I. P., Tangerman, A. & Nagengast, F. M. (1994). Effect of resistant starch on colonic fermentation, bile acid metabolism, and mucosal proliferation. Digestive Diseases and Sciences 39, 834-842.
272. Van Tassell, R. L., Piccariello, T., Kingston, D. G. I. & Wilkins, T. D. (1989). The precursors of fecapentaenes: purification and properties of a novel plasmalogen. Lipids 24, 454-459.
273. Venitt, S., Bosworth, D. & Alldrick, A. J. (1986). Pilot study of the effect of diet on the mutagenicity of human faeces. Mutagenesis 1, 353-358
274. Verhagen, H , Poulsen, H. E., Loft, S., van Poppel, G., Willems, M. I., & van Bladeren, P. J. (1995). Reduction of oxidative DNA-damage in humans by Brussels sprouts. Carcinogenesis 16, 969-970.
275. Visek, W. J. (1978). Diet and cell growth modulation by ammonia. American Journal of Clinical Nutrition 31 (Suppl.), S216-S220
276. Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., Nakamura, Y., White, R., Smits, A. M. M. & Bos, J. L. (1988). Genetic alterations during colorectal-tumour development. New England Journal of Medicine 319, 525-532
277. 3 into nitrate is enhanced by endotoxin treatment. Proceedings of the National Academy of Sciences, USA 80, 4518-4521.
278. Wakabayashi, K., Nagao, M., Esumi, H. & Sugimura, T. (1992). Food-derived mutagens and carcinogens. Cancer Research 52 (Suppl.), 2092-2098s.
279. Ward, F. W., Coates, M. E. & Walker, R. (1989). Influence of dietary protein and gut microflora on endogenesis synthesis of nitrate and N-nitrosamines in the rat. Food and Chemical Toxicology 27, 445-449.
280. Ward, J. M., Anjo, T., Ohannesian, L., Keefer, L. K., Devor, D. E., Donovan, P. J., Smith, G. T., Henneman, J. R., Streeter, A. J , Konishi, N , Rehm, S , Reist, E. J., Bradford, W. W. & Rice, J. M. (1988) Inactivity of fecapentaene-12 as a rodent carcinogen or tumour initiator. Cancer Letters 42, 49-59.
281. Wargovich, M. J. (1987). Diallyl sulphide, a flavour component of garlic (Allium sativum) inhibits dimethylhydrazine-induced colon cancer. Carcinogenesis 8, 487-489.
282. Wattenberg, L. W. (1971). Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Effect of diet on benzpyrene hydroxylase activity. Cancer 28, 99-102.
283. Wattenberg, L. W. (1985). Chemoprevention of cancer. Cancer Research 45, 1-8.
284. Weisburger, J. H. (1993). Heterocyclic amines in foods - possible human carcinogens. Cancer Research 53, 2422-2424.
285. Weisburger, J. H., Jones, R. C., Wang, C.-X., Backlund, J. Y. C., Williams, G. M., Kingston, D. G. I., van Tassell, R. L., Keyes, R. F., Wilkins, T. D., de Wit, P. P , van der Steeg, M. & van der Gen, A. (1990). Carcinogenicity test of fecapentaene-12 in mice and rats. Cancer Letters 49, 89-98.
286. Weisburger, J. H., Rivenson, A , Reinhardt J., Aliaga, C., Braley, J., Dolan, L M., Williams, G. M., Zang, E., Kingston, D. G. I., Bashir, M. et al. (1994). Genotoxicity in rats 7OH IQ, and intestinal metabolite of IQ. Journal of the National Cancer Institute 86, 25-30.
287. Weisgerber, U. M., Boeing, H., Owen, R. W., Waldherr, R., Raedsch, R. & Wahrendorf, J. (1995). Effect of a long term placebo controlled calcium intervention on sigmoidal cell proliferation in patients with sporadic colorectal adenomas. Gut (in press).
288. Whitehead, N., Reyner, F. & Lindenbaum, J. (1973). Megaloblastic changes in the cervical epithelium. Journal of the American Medical Association 226, 1421-1424.
289. Willett, W C., Stampfer, M. J., Colditz, G. A., Rosner, B. A. & Speizer, F. E. (1990). Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. New England Journal of Medicine 323, 1664-1672.
290. Williams, R. T. (1978). Nutrients in drug detoxification mechanisms. In Nutrition in Drug Interrelations, pp. 303-318 [J. Coon and J. H. Hathcock, editors]. New York: Academic Press.
291. Witter, J. P., Balish, E. & Galley, S. J. (1979). Origin of excess urinary nitrate in the rat. Cancer Research 42, 3645-3648.
292. World Health Organization (1973). Energy and Protein Requirements (Technical Report Series no. 522) Geneva: WHO.
293. World Health Organization (1990). Diet, Nutrition and the Prevention of Chronic Disease (Technical Report Series no. 797). Geneva: WHO.
294. Yamane, T., Hagiwara, N., Tateishi, M., Akachi, S., Kim, M., Okuzumi, J., Kitao, Y., Inagake, M., Kuwata, K. & Takahashi, T. (1991). Inhibition of azoxymethane-induced colon carcinogenesis in rats by green tea polyphenol fraction. Japanese Journal of Cancer Research 82, 1336-1339.
295. Yang, C. S. & Wang, Z. Y. (1993). Tea and cancer. Journal of the National Cancer Institute 85, 1038-1049.
296. Yang, C. S. & Yoo, J.-S. H. (1991). Nutrition and hepatic drug metabolism. In Nutrition, Toxicity and Cancer, pp. [I R. Rowland, editor]. Boca Raton, FL: CRC Press.
297. Yin, P. Z., Zhao, J Y., Cheng, S. L., Hara, Y., Zhu, Q. F. & Liu, Z. G. (1994). Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1,2-dimethylhydrazine. Cancer Letters 79, 33-38.
298. Young, G. P., McIntyre, A., Albert, V., Folino, M., Muir, J. & Gibson, P. R. (1996). Wheat bran suppresses potato starch-potentiated colorectal tumorigenesis at the aberrant crypt stage in a rat model. Gastroenterology 110, 508-514.
299. Zaridze, D., Filipchenko, V., Kustov, V., Serdyuk, V. & Duffy, S. (1993) Diet and colorectal cancer: results of two case-control studies in Russia. European Journal of Cancer 29A, 112-115.
300. Zarkovic, M., Qin, X. S., Nakatsuru, Y , Oda, H., Nakamura, T., Shamsuddin, A. M. & Ishikawa, T. (1993). Tumour promotion by fecapentaene-12 in a rat colon carcinogenesis model. Carcinogenesis 14, 1261-1264.
301. Zhang, Y., Talalay, P., Cho, C.-G. & Posner, G. H. (1992). A major inducer of anticarcinogenic protective enzymes from broccoli : isolation and elucidation of structure. Proceedings of the National Academy of Sciences, USA 89, 2399-2403.
302. Zimmerman, J. (1993). Does dietary calcium supplementation reduce the risk of cancer? Nutrition Reviews 51, 109-112.