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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For reviews of the enediyne antitumor antibiotics and general enediyne chemistry, see: (a) Grissom, J. W.; Gunawardena, G. U.; Klingberg, D.; Huang, D. Tetrahedron. 1996, 52, 6453. (b) Wang, K. K. Chem. Rev. 1996, 96, 207. (c) Danishefsky, S. J.; Shair, M. D. J. Org. Chem. 1996, 61, 16. Pratviel, G.; Bernadou, J.; Meunier, B. Angew. Chem., Int. Ed. Engl. 1995, 34, 746. (e) Maier, M. E. Synlett 1995, 13. (f) Hirama, M. J. Synth. Org. Chem. Jpn. 1994, 52, 980. (g) Maier, M. E. Kontakte 1994, 3. (h) Thebtaranonth, C.; Thebtaranonth, Y. Cyclization Reactions, CRC Press: Boca Raton, FL, 1994. (i) Nicolaou, K. C. Chem. Brit. 1994, 30, 33. (j) Nicolaou, K. C. Angew. Chem., Int. Ed. Engl. 1993, 32, 1377. (k) Nicolaou, K. C.; Smith, A. L.; Yue, E. W. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5881. (l) Nicolaou, K. C.; Smith, A. L. Pure Appl. Chem. 1993, 65, 1271. (m) Hoffman, R. American Scientist 1993, 81, 324. (n) Hirama, M. Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products; Lukacs, G., Ed.; Springer-Verlag: Berlin, 1993; Vol. 2. (o) Skrydstrup, T.; Ulibarri, G.; Audrain, H.; Grierson, D., ref In. (p) Gleiter, R.; Kratz, D. Angew. Chem., Int. Ed. Engl. 1993, 32, 842. (q) Nicolaou, K. C.; Dai, W.-M.; Tsay, S.-C.; Estevez, V. A.; Wrasidlo, W. Science 1992, 256, 1172. (r) Nicolaou, K. C.; Smith, A. L. Acc. Chem. Res. 1992, 25, 497. (s) Nicolaou, K. C.; Dai, W.-M. Angew. Chem., Int. Ed. Engl. 1991, 30, 1387. (t) Lee, M. D.; Ellestad, G. A.; Borders, D. B. Acc. Chem. Res. 1991, 24, 235. (u) Goldberg, I. H. Acc. Chem. Res. 1991, 24, 191. Waldmann, H. Nachr. Chem. Tech. Lab. 1991, 39, 211.
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For the use of oxime ethers in radical cyclization reactions, see: (a) Chiara, J. L.; Marco-Contelles, J.; Khiar, N.; Gallego, P.; Destabel, C.; Bernabé, M. J. Org. Chem. 1995, 60, 6010. (b) Marco-Contelles, J.; Destabel, C.; Chiara, J. L.; Bernabé, M. Tetrahedron: Asymmetry 1995, 6, 1547. (c) Keck, G. E.; McHardy, S. F.; Murry, J. A. J. Am. Chem. Soc. 1995, 117, 7289. (d) Santagostino, M.; Kilburn, J. D. Tetrahedron Lett. 1995, 36, 1365. (e) Kiguchi, T.; Tajiri, K.; Ninimiya, I.; Naito, T.; Hiramatsu, H. Tetrahedron Lett. 1995, 36, 253. (f) Booth, S. E.; Jenkins, P. R.; Swain, C. J.; Sweeney, J. B. J. Chem. Soc., Perkin Trans. 1 1994, 3499. (g) Naito, T.; Tajiri, K.; Harimoto, T.; Ninomiya, I.; Kiguchi, T. Tetrahedron Lett. 1994, 35, 2205. (h) Ingall, A. H.; Moore, P. R.; Roberts, S. M. J. Chem. Soc., Chem. Commun. 1994, 83. (i) Pattenden, G.; Schultz, D. J. Tetrahedron Lett. 1993, 34, 6787. (j) Marco-Contelles, J.; Ruiz, P.; Martínez, L.; Martínez-Grau, A. Tetrahedron 1993, 49, 6669. (k) Simpkins, N. S.; Stokes, S.; Whittle, A. J. J. Chem. Soc., Perkin Trans. 1 1992, 2471. (l) Marco-Contelles, J.; Ruiz, P.; Sánchez, B.; Jimeno, M. L. Tetrahedron Lett. 1992, 33, 5261. (m) Hatem, J.; Henriet-Bernard, C.; Grimaldi, J.; Maurin, R. Tetrahedron Lett. 1992, 33, 1057. (n) Marco-Contelles, J.; Pozuelo, C.; Jimeno, M. L.; Martínez, L.; Martínez-Grau, A. J. Org. Chem. 1992, 57, 2625. (o) Booth, S. E.; Jenkins, P. R.; Swain, C. J. J. Chem. Soc., Chem. Commun. 1991, 1248. (p) Marco-Contelles, J.; Martínez, L.; Martínez-Grau, A. Tetrahedron: Asymmetry 1991, 2, 961. (q) Marco-Contelles, J.; Martínez-Grau, A.; Bernabe, M.; Martin, N.; Seoane, C. Synlett 1991, 165. (r) Enholm, E. J.; Burroff, J. A.; Jaramillo, L. M. Tetrahedron Lett. 1990, 31, 3727. (s) Parker, K. A.; Spero, D. M.; Van Epp, J. J. Org. Chem. 1988, 53, 4628. (t) Bartlett, P. A.; McLaren, K. L.; Ting, P. C. J. Am. Chem. Soc. 1988, 110, 1633. (u) Hart, D. J.; Seely, F. L. J. Am. Chem. Soc. 1988, 110, 1631. Corey, E. J.; Pyne, S. G. Tetrahedron Lett. 1983, 24, 2821.
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For the use of oxime ethers in radical cyclization reactions, see: (a) Chiara, J. L.; Marco-Contelles, J.; Khiar, N.; Gallego, P.; Destabel, C.; Bernabé, M. J. Org. Chem. 1995, 60, 6010. (b) Marco-Contelles, J.; Destabel, C.; Chiara, J. L.; Bernabé, M. Tetrahedron: Asymmetry 1995, 6, 1547. (c) Keck, G. E.; McHardy, S. F.; Murry, J. A. J. Am. Chem. Soc. 1995, 117, 7289. (d) Santagostino, M.; Kilburn, J. D. Tetrahedron Lett. 1995, 36, 1365. (e) Kiguchi, T.; Tajiri, K.; Ninimiya, I.; Naito, T.; Hiramatsu, H. Tetrahedron Lett. 1995, 36, 253. (f) Booth, S. E.; Jenkins, P. R.; Swain, C. J.; Sweeney, J. B. J. Chem. Soc., Perkin Trans. 1 1994, 3499. (g) Naito, T.; Tajiri, K.; Harimoto, T.; Ninomiya, I.; Kiguchi, T. Tetrahedron Lett. 1994, 35, 2205. (h) Ingall, A. H.; Moore, P. R.; Roberts, S. M. J. Chem. Soc., Chem. Commun. 1994, 83. (i) Pattenden, G.; Schultz, D. J. Tetrahedron Lett. 1993, 34, 6787. (j) Marco-Contelles, J.; Ruiz, P.; Martínez, L.; Martínez-Grau, A. Tetrahedron 1993, 49, 6669. (k) Simpkins, N. S.; Stokes, S.; Whittle, A. J. J. Chem. Soc., Perkin Trans. 1 1992, 2471. (l) Marco-Contelles, J.; Ruiz, P.; Sánchez, B.; Jimeno, M. L. Tetrahedron Lett. 1992, 33, 5261. (m) Hatem, J.; Henriet-Bernard, C.; Grimaldi, J.; Maurin, R. Tetrahedron Lett. 1992, 33, 1057. (n) Marco-Contelles, J.; Pozuelo, C.; Jimeno, M. L.; Martínez, L.; Martínez-Grau, A. J. Org. Chem. 1992, 57, 2625. (o) Booth, S. E.; Jenkins, P. R.; Swain, C. J. J. Chem. Soc., Chem. Commun. 1991, 1248. (p) Marco-Contelles, J.; Martínez, L.; Martínez-Grau, A. Tetrahedron: Asymmetry 1991, 2, 961. (q) Marco-Contelles, J.; Martínez-Grau, A.; Bernabe, M.; Martin, N.; Seoane, C. Synlett 1991, 165. (r) Enholm, E. J.; Burroff, J. A.; Jaramillo, L. M. Tetrahedron Lett. 1990, 31, 3727. (s) Parker, K. A.; Spero, D. M.; Van Epp, J. J. Org. Chem. 1988, 53, 4628. (t) Bartlett, P. A.; McLaren, K. L.; Ting, P. C. J. Am. Chem. Soc. 1988, 110, 1633. (u) Hart, D. J.; Seely, F. L. J. Am. Chem. Soc. 1988, 110, 1631. Corey, E. J.; Pyne, S. G. Tetrahedron Lett. 1983, 24, 2821.
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For the use of oxime ethers in radical cyclization reactions, see: (a) Chiara, J. L.; Marco-Contelles, J.; Khiar, N.; Gallego, P.; Destabel, C.; Bernabé, M. J. Org. Chem. 1995, 60, 6010. (b) Marco-Contelles, J.; Destabel, C.; Chiara, J. L.; Bernabé, M. Tetrahedron: Asymmetry 1995, 6, 1547. (c) Keck, G. E.; McHardy, S. F.; Murry, J. A. J. Am. Chem. Soc. 1995, 117, 7289. (d) Santagostino, M.; Kilburn, J. D. Tetrahedron Lett. 1995, 36, 1365. (e) Kiguchi, T.; Tajiri, K.; Ninimiya, I.; Naito, T.; Hiramatsu, H. Tetrahedron Lett. 1995, 36, 253. (f) Booth, S. E.; Jenkins, P. R.; Swain, C. J.; Sweeney, J. B. J. Chem. Soc., Perkin Trans. 1 1994, 3499. (g) Naito, T.; Tajiri, K.; Harimoto, T.; Ninomiya, I.; Kiguchi, T. Tetrahedron Lett. 1994, 35, 2205. (h) Ingall, A. H.; Moore, P. R.; Roberts, S. M. J. Chem. Soc., Chem. Commun. 1994, 83. (i) Pattenden, G.; Schultz, D. J. Tetrahedron Lett. 1993, 34, 6787. (j) Marco-Contelles, J.; Ruiz, P.; Martínez, L.; Martínez-Grau, A. Tetrahedron 1993, 49, 6669. (k) Simpkins, N. S.; Stokes, S.; Whittle, A. J. J. Chem. Soc., Perkin Trans. 1 1992, 2471. (l) Marco-Contelles, J.; Ruiz, P.; Sánchez, B.; Jimeno, M. L. Tetrahedron Lett. 1992, 33, 5261. (m) Hatem, J.; Henriet-Bernard, C.; Grimaldi, J.; Maurin, R. Tetrahedron Lett. 1992, 33, 1057. (n) Marco-Contelles, J.; Pozuelo, C.; Jimeno, M. L.; Martínez, L.; Martínez-Grau, A. J. Org. Chem. 1992, 57, 2625. (o) Booth, S. E.; Jenkins, P. R.; Swain, C. J. J. Chem. Soc., Chem. Commun. 1991, 1248. (p) Marco-Contelles, J.; Martínez, L.; Martínez-Grau, A. Tetrahedron: Asymmetry 1991, 2, 961. (q) Marco-Contelles, J.; Martínez-Grau, A.; Bernabe, M.; Martin, N.; Seoane, C. Synlett 1991, 165. (r) Enholm, E. J.; Burroff, J. A.; Jaramillo, L. M. Tetrahedron Lett. 1990, 31, 3727. (s) Parker, K. A.; Spero, D. M.; Van Epp, J. J. Org. Chem. 1988, 53, 4628. (t) Bartlett, P. A.; McLaren, K. L.; Ting, P. C. J. Am. Chem. Soc. 1988, 110, 1633. (u) Hart, D. J.; Seely, F. L. J. Am. Chem. Soc. 1988, 110, 1631. Corey, E. J.; Pyne, S. G. Tetrahedron Lett. 1983, 24, 2821.
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For the use of oxime ethers in radical cyclization reactions, see: (a) Chiara, J. L.; Marco-Contelles, J.; Khiar, N.; Gallego, P.; Destabel, C.; Bernabé, M. J. Org. Chem. 1995, 60, 6010. (b) Marco-Contelles, J.; Destabel, C.; Chiara, J. L.; Bernabé, M. Tetrahedron: Asymmetry 1995, 6, 1547. (c) Keck, G. E.; McHardy, S. F.; Murry, J. A. J. Am. Chem. Soc. 1995, 117, 7289. (d) Santagostino, M.; Kilburn, J. D. Tetrahedron Lett. 1995, 36, 1365. (e) Kiguchi, T.; Tajiri, K.; Ninimiya, I.; Naito, T.; Hiramatsu, H. Tetrahedron Lett. 1995, 36, 253. (f) Booth, S. E.; Jenkins, P. R.; Swain, C. J.; Sweeney, J. B. J. Chem. Soc., Perkin Trans. 1 1994, 3499. (g) Naito, T.; Tajiri, K.; Harimoto, T.; Ninomiya, I.; Kiguchi, T. Tetrahedron Lett. 1994, 35, 2205. (h) Ingall, A. H.; Moore, P. R.; Roberts, S. M. J. Chem. Soc., Chem. Commun. 1994, 83. (i) Pattenden, G.; Schultz, D. J. Tetrahedron Lett. 1993, 34, 6787. (j) Marco-Contelles, J.; Ruiz, P.; Martínez, L.; Martínez-Grau, A. Tetrahedron 1993, 49, 6669. (k) Simpkins, N. S.; Stokes, S.; Whittle, A. J. J. Chem. Soc., Perkin Trans. 1 1992, 2471. (l) Marco-Contelles, J.; Ruiz, P.; Sánchez, B.; Jimeno, M. L. Tetrahedron Lett. 1992, 33, 5261. (m) Hatem, J.; Henriet-Bernard, C.; Grimaldi, J.; Maurin, R. Tetrahedron Lett. 1992, 33, 1057. (n) Marco-Contelles, J.; Pozuelo, C.; Jimeno, M. L.; Martínez, L.; Martínez-Grau, A. J. Org. Chem. 1992, 57, 2625. (o) Booth, S. E.; Jenkins, P. R.; Swain, C. J. J. Chem. Soc., Chem. Commun. 1991, 1248. (p) Marco-Contelles, J.; Martínez, L.; Martínez-Grau, A. Tetrahedron: Asymmetry 1991, 2, 961. (q) Marco-Contelles, J.; Martínez-Grau, A.; Bernabe, M.; Martin, N.; Seoane, C. Synlett 1991, 165. (r) Enholm, E. J.; Burroff, J. A.; Jaramillo, L. M. Tetrahedron Lett. 1990, 31, 3727. (s) Parker, K. A.; Spero, D. M.; Van Epp, J. J. Org. Chem. 1988, 53, 4628. (t) Bartlett, P. A.; McLaren, K. L.; Ting, P. C. J. Am. Chem. Soc. 1988, 110, 1633. (u) Hart, D. J.; Seely, F. L. J. Am. Chem. Soc. 1988, 110, 1631. Corey, E. J.; Pyne, S. G. Tetrahedron Lett. 1983, 24, 2821.
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For the use of oxime ethers in radical cyclization reactions, see: (a) Chiara, J. L.; Marco-Contelles, J.; Khiar, N.; Gallego, P.; Destabel, C.; Bernabé, M. J. Org. Chem. 1995, 60, 6010. (b) Marco-Contelles, J.; Destabel, C.; Chiara, J. L.; Bernabé, M. Tetrahedron: Asymmetry 1995, 6, 1547. (c) Keck, G. E.; McHardy, S. F.; Murry, J. A. J. Am. Chem. Soc. 1995, 117, 7289. (d) Santagostino, M.; Kilburn, J. D. Tetrahedron Lett. 1995, 36, 1365. (e) Kiguchi, T.; Tajiri, K.; Ninimiya, I.; Naito, T.; Hiramatsu, H. Tetrahedron Lett. 1995, 36, 253. (f) Booth, S. E.; Jenkins, P. R.; Swain, C. J.; Sweeney, J. B. J. Chem. Soc., Perkin Trans. 1 1994, 3499. (g) Naito, T.; Tajiri, K.; Harimoto, T.; Ninomiya, I.; Kiguchi, T. Tetrahedron Lett. 1994, 35, 2205. (h) Ingall, A. H.; Moore, P. R.; Roberts, S. M. J. Chem. Soc., Chem. Commun. 1994, 83. (i) Pattenden, G.; Schultz, D. J. Tetrahedron Lett. 1993, 34, 6787. (j) Marco-Contelles, J.; Ruiz, P.; Martínez, L.; Martínez-Grau, A. Tetrahedron 1993, 49, 6669. (k) Simpkins, N. S.; Stokes, S.; Whittle, A. J. J. Chem. Soc., Perkin Trans. 1 1992, 2471. (l) Marco-Contelles, J.; Ruiz, P.; Sánchez, B.; Jimeno, M. L. Tetrahedron Lett. 1992, 33, 5261. (m) Hatem, J.; Henriet-Bernard, C.; Grimaldi, J.; Maurin, R. Tetrahedron Lett. 1992, 33, 1057. (n) Marco-Contelles, J.; Pozuelo, C.; Jimeno, M. L.; Martínez, L.; Martínez-Grau, A. J. Org. Chem. 1992, 57, 2625. (o) Booth, S. E.; Jenkins, P. R.; Swain, C. J. J. Chem. Soc., Chem. Commun. 1991, 1248. (p) Marco-Contelles, J.; Martínez, L.; Martínez-Grau, A. Tetrahedron: Asymmetry 1991, 2, 961. (q) Marco-Contelles, J.; Martínez-Grau, A.; Bernabe, M.; Martin, N.; Seoane, C. Synlett 1991, 165. (r) Enholm, E. J.; Burroff, J. A.; Jaramillo, L. M. Tetrahedron Lett. 1990, 31, 3727. (s) Parker, K. A.; Spero, D. M.; Van Epp, J. J. Org. Chem. 1988, 53, 4628. (t) Bartlett, P. A.; McLaren, K. L.; Ting, P. C. J. Am. Chem. Soc. 1988, 110, 1633. (u) Hart, D. J.; Seely, F. L. J. Am. Chem. Soc. 1988, 110, 1631. Corey, E. J.; Pyne, S. G. Tetrahedron Lett. 1983, 24, 2821.
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For the use of oxime ethers in radical cyclization reactions, see: (a) Chiara, J. L.; Marco-Contelles, J.; Khiar, N.; Gallego, P.; Destabel, C.; Bernabé, M. J. Org. Chem. 1995, 60, 6010. (b) Marco-Contelles, J.; Destabel, C.; Chiara, J. L.; Bernabé, M. Tetrahedron: Asymmetry 1995, 6, 1547. (c) Keck, G. E.; McHardy, S. F.; Murry, J. A. J. Am. Chem. Soc. 1995, 117, 7289. (d) Santagostino, M.; Kilburn, J. D. Tetrahedron Lett. 1995, 36, 1365. (e) Kiguchi, T.; Tajiri, K.; Ninimiya, I.; Naito, T.; Hiramatsu, H. Tetrahedron Lett. 1995, 36, 253. (f) Booth, S. E.; Jenkins, P. R.; Swain, C. J.; Sweeney, J. B. J. Chem. Soc., Perkin Trans. 1 1994, 3499. (g) Naito, T.; Tajiri, K.; Harimoto, T.; Ninomiya, I.; Kiguchi, T. Tetrahedron Lett. 1994, 35, 2205. (h) Ingall, A. H.; Moore, P. R.; Roberts, S. M. J. Chem. Soc., Chem. Commun. 1994, 83. (i) Pattenden, G.; Schultz, D. J. Tetrahedron Lett. 1993, 34, 6787. (j) Marco-Contelles, J.; Ruiz, P.; Martínez, L.; Martínez-Grau, A. Tetrahedron 1993, 49, 6669. (k) Simpkins, N. S.; Stokes, S.; Whittle, A. J. J. Chem. Soc., Perkin Trans. 1 1992, 2471. (l) Marco-Contelles, J.; Ruiz, P.; Sánchez, B.; Jimeno, M. L. Tetrahedron Lett. 1992, 33, 5261. (m) Hatem, J.; Henriet-Bernard, C.; Grimaldi, J.; Maurin, R. Tetrahedron Lett. 1992, 33, 1057. (n) Marco-Contelles, J.; Pozuelo, C.; Jimeno, M. L.; Martínez, L.; Martínez-Grau, A. J. Org. Chem. 1992, 57, 2625. (o) Booth, S. E.; Jenkins, P. R.; Swain, C. J. J. Chem. Soc., Chem. Commun. 1991, 1248. (p) Marco-Contelles, J.; Martínez, L.; Martínez-Grau, A. Tetrahedron: Asymmetry 1991, 2, 961. (q) Marco-Contelles, J.; Martínez-Grau, A.; Bernabe, M.; Martin, N.; Seoane, C. Synlett 1991, 165. (r) Enholm, E. J.; Burroff, J. A.; Jaramillo, L. M. Tetrahedron Lett. 1990, 31, 3727. (s) Parker, K. A.; Spero, D. M.; Van Epp, J. J. Org. Chem. 1988, 53, 4628. (t) Bartlett, P. A.; McLaren, K. L.; Ting, P. C. J. Am. Chem. Soc. 1988, 110, 1633. (u) Hart, D. J.; Seely, F. L. J. Am. Chem. Soc. 1988, 110, 1631. Corey, E. J.; Pyne, S. G. Tetrahedron Lett. 1983, 24, 2821.
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For the use of oxime ethers in radical cyclization reactions, see: (a) Chiara, J. L.; Marco-Contelles, J.; Khiar, N.; Gallego, P.; Destabel, C.; Bernabé, M. J. Org. Chem. 1995, 60, 6010. (b) Marco-Contelles, J.; Destabel, C.; Chiara, J. L.; Bernabé, M. Tetrahedron: Asymmetry 1995, 6, 1547. (c) Keck, G. E.; McHardy, S. F.; Murry, J. A. J. Am. Chem. Soc. 1995, 117, 7289. (d) Santagostino, M.; Kilburn, J. D. Tetrahedron Lett. 1995, 36, 1365. (e) Kiguchi, T.; Tajiri, K.; Ninimiya, I.; Naito, T.; Hiramatsu, H. Tetrahedron Lett. 1995, 36, 253. (f) Booth, S. E.; Jenkins, P. R.; Swain, C. J.; Sweeney, J. B. J. Chem. Soc., Perkin Trans. 1 1994, 3499. (g) Naito, T.; Tajiri, K.; Harimoto, T.; Ninomiya, I.; Kiguchi, T. Tetrahedron Lett. 1994, 35, 2205. (h) Ingall, A. H.; Moore, P. R.; Roberts, S. M. J. Chem. Soc., Chem. Commun. 1994, 83. (i) Pattenden, G.; Schultz, D. J. Tetrahedron Lett. 1993, 34, 6787. (j) Marco-Contelles, J.; Ruiz, P.; Martínez, L.; Martínez-Grau, A. Tetrahedron 1993, 49, 6669. (k) Simpkins, N. S.; Stokes, S.; Whittle, A. J. J. Chem. Soc., Perkin Trans. 1 1992, 2471. (l) Marco-Contelles, J.; Ruiz, P.; Sánchez, B.; Jimeno, M. L. Tetrahedron Lett. 1992, 33, 5261. (m) Hatem, J.; Henriet-Bernard, C.; Grimaldi, J.; Maurin, R. Tetrahedron Lett. 1992, 33, 1057. (n) Marco-Contelles, J.; Pozuelo, C.; Jimeno, M. L.; Martínez, L.; Martínez-Grau, A. J. Org. Chem. 1992, 57, 2625. (o) Booth, S. E.; Jenkins, P. R.; Swain, C. J. J. Chem. Soc., Chem. Commun. 1991, 1248. (p) Marco-Contelles, J.; Martínez, L.; Martínez-Grau, A. Tetrahedron: Asymmetry 1991, 2, 961. (q) Marco-Contelles, J.; Martínez-Grau, A.; Bernabe, M.; Martin, N.; Seoane, C. Synlett 1991, 165. (r) Enholm, E. J.; Burroff, J. A.; Jaramillo, L. M. Tetrahedron Lett. 1990, 31, 3727. (s) Parker, K. A.; Spero, D. M.; Van Epp, J. J. Org. Chem. 1988, 53, 4628. (t) Bartlett, P. A.; McLaren, K. L.; Ting, P. C. J. Am. Chem. Soc. 1988, 110, 1633. (u) Hart, D. J.; Seely, F. L. J. Am. Chem. Soc. 1988, 110, 1631. Corey, E. J.; Pyne, S. G. Tetrahedron Lett. 1983, 24, 2821.
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For general reviews of the Horner-Emmons reaction, see: (a) Maryanoff, B. E.; Reitz, A. B. Chem. Rev. 1989, 89, 863. (b) Wadsworth, W. S., Jr. Org. React. 1977, 25, 73. Boutagy, J.; Thomas, R. Chem. Rev. 1974, 74, 87. For Wittig reactions or Horner-Emmons reactions that employ cyano-substituted phosphoranes or cyanomethyl-substituted phosphonates, see: (d) Ullas, G. V.; Chu, C. K.; Ahn, M. K.; Kosugi, Y. J. Org. Chem. 1988, 53, 2413. (e) Piechucki, C. Synthesis 1974, 869. (f) Tronchet, J. M. J.; Baehler, B.; Eder, H.; Le-Hong, N.; Perret, F.; Poncet, J.; Zumwald, J.-B. Helv. Chim. Acta 1973, 56, 1310. (g) Bose, A. K.; Dahill, R. T., Jr. J. Org. Chem. 1965, 30, 505. (h) Schiemenz, G. P.; Engelhard, H. Chem. Ber. 1961, 94, 578.
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For general reviews of the Horner-Emmons reaction, see: (a) Maryanoff, B. E.; Reitz, A. B. Chem. Rev. 1989, 89, 863. (b) Wadsworth, W. S., Jr. Org. React. 1977, 25, 73. Boutagy, J.; Thomas, R. Chem. Rev. 1974, 74, 87. For Wittig reactions or Horner-Emmons reactions that employ cyano-substituted phosphoranes or cyanomethyl-substituted phosphonates, see: (d) Ullas, G. V.; Chu, C. K.; Ahn, M. K.; Kosugi, Y. J. Org. Chem. 1988, 53, 2413. (e) Piechucki, C. Synthesis 1974, 869. (f) Tronchet, J. M. J.; Baehler, B.; Eder, H.; Le-Hong, N.; Perret, F.; Poncet, J.; Zumwald, J.-B. Helv. Chim. Acta 1973, 56, 1310. (g) Bose, A. K.; Dahill, R. T., Jr. J. Org. Chem. 1965, 30, 505. (h) Schiemenz, G. P.; Engelhard, H. Chem. Ber. 1961, 94, 578.
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For general reviews of the Horner-Emmons reaction, see: (a) Maryanoff, B. E.; Reitz, A. B. Chem. Rev. 1989, 89, 863. (b) Wadsworth, W. S., Jr. Org. React. 1977, 25, 73. Boutagy, J.; Thomas, R. Chem. Rev. 1974, 74, 87. For Wittig reactions or Horner-Emmons reactions that employ cyano-substituted phosphoranes or cyanomethyl-substituted phosphonates, see: (d) Ullas, G. V.; Chu, C. K.; Ahn, M. K.; Kosugi, Y. J. Org. Chem. 1988, 53, 2413. (e) Piechucki, C. Synthesis 1974, 869. (f) Tronchet, J. M. J.; Baehler, B.; Eder, H.; Le-Hong, N.; Perret, F.; Poncet, J.; Zumwald, J.-B. Helv. Chim. Acta 1973, 56, 1310. (g) Bose, A. K.; Dahill, R. T., Jr. J. Org. Chem. 1965, 30, 505. (h) Schiemenz, G. P.; Engelhard, H. Chem. Ber. 1961, 94, 578.
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For general reviews of the Horner-Emmons reaction, see: (a) Maryanoff, B. E.; Reitz, A. B. Chem. Rev. 1989, 89, 863. (b) Wadsworth, W. S., Jr. Org. React. 1977, 25, 73. Boutagy, J.; Thomas, R. Chem. Rev. 1974, 74, 87. For Wittig reactions or Horner-Emmons reactions that employ cyano-substituted phosphoranes or cyanomethyl-substituted phosphonates, see: (d) Ullas, G. V.; Chu, C. K.; Ahn, M. K.; Kosugi, Y. J. Org. Chem. 1988, 53, 2413. (e) Piechucki, C. Synthesis 1974, 869. (f) Tronchet, J. M. J.; Baehler, B.; Eder, H.; Le-Hong, N.; Perret, F.; Poncet, J.; Zumwald, J.-B. Helv. Chim. Acta 1973, 56, 1310. (g) Bose, A. K.; Dahill, R. T., Jr. J. Org. Chem. 1965, 30, 505. (h) Schiemenz, G. P.; Engelhard, H. Chem. Ber. 1961, 94, 578.
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For general reviews of the Horner-Emmons reaction, see: (a) Maryanoff, B. E.; Reitz, A. B. Chem. Rev. 1989, 89, 863. (b) Wadsworth, W. S., Jr. Org. React. 1977, 25, 73. Boutagy, J.; Thomas, R. Chem. Rev. 1974, 74, 87. For Wittig reactions or Horner-Emmons reactions that employ cyano-substituted phosphoranes or cyanomethyl-substituted phosphonates, see: (d) Ullas, G. V.; Chu, C. K.; Ahn, M. K.; Kosugi, Y. J. Org. Chem. 1988, 53, 2413. (e) Piechucki, C. Synthesis 1974, 869. (f) Tronchet, J. M. J.; Baehler, B.; Eder, H.; Le-Hong, N.; Perret, F.; Poncet, J.; Zumwald, J.-B. Helv. Chim. Acta 1973, 56, 1310. (g) Bose, A. K.; Dahill, R. T., Jr. J. Org. Chem. 1965, 30, 505. (h) Schiemenz, G. P.; Engelhard, H. Chem. Ber. 1961, 94, 578.
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(b) For a review of the oxidizing agent tetra-n-propylammonium perruthenate (TPAP), see: Ley, S. V.; Norman, J.; Griffith, W. P.; Marsden, S. P. Synthesis 1994, 639.
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Ley, S.V.1
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General experimental techniques are described in ref 7d
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General experimental techniques are described in ref 7d.
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