Kinetic preference of 5′GMP over 3′GMP in reactions with platinum amine compounds as studied by competition reactions

Inorganica Chimica Acta

Volumn 176, Issue 2, 1990, Pages 317-320

  Bloemink, Marieke J ^a   Lempers, Edwin L M ^a   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001016580     PISSN: 00201693     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-1693(00)84862-8     Document Type: Article

References (23)

1. Platinum amine coordination compounds as anti-tumor drugs. Molecular aspects of the mechanism of action
2. Determination of platinum binding bases by enzymatic digestion.
3. Reaction of the antitumor drug cis-diamminedichloroplatinum(II) with the trinucleotide d(GpApG): identification of the two main products and kinetic aspects of their formation
4. Implication of 195Pt chemical shift anisotropy relaxation in n.m.r. studies of platinum complexes
5. Crystal and molecular structure of cis-[Pt(NH3)2[d(pGpG)]], the principal adduct formed by cis-diamminedichloroplatinum(II) with DNA
6. The new antitumor compound, cis-[Pt(NH3)2(4-methylpyridine)Cl]Cl, does not form N7,N7-d(GpG) chelates with DNA. An unexpected preference for platinum binding at the 5'G in d(GpG).