Contribution of a prosegment lysine residue to the function and structure of porcine pepsinogen A and its active form pepsin A

European Journal of Biochemistry

Volumn 261, Issue 3, 1999, Pages 746-752

  Richter, Catherine ^b   Tanaka, Takuji ^b   Koseki, Taihei ^b   Yada, Rickey Y ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b NONE

Author keywords

Activation; Aspartic protease; Conformation stability; Protein folding; Structure function relationship

Indexed keywords

ARGININE; ASPARTIC ACID; ENZYME PRECURSOR; GLUTAMIC ACID; LYSINE; METHIONINE; MUTANT PROTEIN; PEPSIN A; PEPSINOGEN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME DENATURATION; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; MICROCALORIMETRY; MOLECULAR MODEL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS; SWINE;

ANIMALS; BASE SEQUENCE; CALORIMETRY, DIFFERENTIAL SCANNING; DNA PRIMERS; ENZYME ACTIVATION; HYDROLYSIS; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPSIN A; PEPSINOGEN A; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0000992986     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00329.x     Document Type: Article

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