Double anionic cycloaromatization of 2-(6-substituted-3-hexene-1,5-diynyl)-benzonitriles initiated by methoxide addition

Organic Letters

Volumn 1, Issue 5, 1999, Pages 767-768

  Wu, Ming Jung ^a   Lin, Chi Fong ^a   Chen, Shang Hung ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

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Indexed keywords

EID: 0000987647     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990137y     Document Type: Article

References (10)

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7. Lews, J. R. Nat. Prod. Rep. 1997, 14, 303.
8. (a) Mislow, K. Introduction of Stereochemistry, Benjamin: Reading, MA, 1965; pp 78-82.
9. (b) Oki, M. Top. Stereochem. 1983, 14, 1.
10. 2 using palladium(0) as a catalyst to give 2-(2-trimethylsilylethynyl)benzonitrile (12) in 45% yield; and finally the trimethylsilyl group of 12 was removed by treatment of 12 with tetrabutylammonium fluoride to give 3 in 97% yield.