The Effects of Two New Amphetamine-like Derivatives on the Phagocytic Ability of the Protozoan, Tetrahymena pyriformis

Alternatives to Laboratory Animals

Volumn 25, Issue 5, 1997, Pages 547-553

  Alevisopoulos, Giorgos ^a   Stefanidou, Maria ^a   Pagou, Margarita ^a   Siatra Papastaikoudi, Theodora ^b   Koutselinis, Antonios ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Amphetamines; Haloperidol; Lipophilicity; Protozoan; Tetrahymena pyriformis

Indexed keywords

PROTOZOA; TETRAHYMENA PYRIFORMIS;

EID: 0000951185     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Angrist, B.M., Sathanathan, G., Wilks, S. & Gershom, S. (1974). Amphetamine psychosis: behavioral and biochemical aspects. Journal of Psychiatric Research 11, 13-23.
2. Davis, J.M. & Glassman, A.H. (1989). Antidepressant drugs. In Comprehensive Textbook of Psychiatry, 5th edn (ed. H. Kaplan & B. Sadock), pp. 1652-1653, Baltimore, MD, USA: Williams & Wilkins.
3. Cuomo, M.J., Dyment, P.G. & Gammino, V M. (1994). Increasing use of ecstasy (MDMA) and other hallucinogens on a college campus. Journal of American College Health 42, 271-274.
4. Golbe, L.I., Langston, J W. & Shoulson, I. (1990). Selegiline and Parkinson's disease protective and symptomatic considerations. Drugs 39, 646-651.
5. Bergrom, R.F., Lemberger, L., Farld, N.A. & Wolen, R.N. (1988). Clinical pharmacology and pharmacokinetics of fluoxetine: a review. In Progress in Antidepressant Therapy (ed. H. Freeman). British Journal of Psychiatry 153, Suppl 3, 47-50.
6. Stefanidou, M., Georgiou, M., Maravelias, C. & Koutselinis, A. (1990). The effects of morphine, cocaine, amphetamine and hashish on phagocytosis of the protozoan Tetrahymena pyriformis strain W. Toxicology in Vitro 4, 779-781.
7. Rothstein, T.L. & Blum, J.J. (1974). Lysosomal physiology in Tetrahymena. IV Effect of dichloroisoproterenol on the intracellular source of released acid hydrolases. Experimental Cell Research 87, 168-174.
8. Fok, A.K. & Shockley, B.U. (1985). Processing of digestive vacuoles in Tetrahymena and the effects of dichloroisoproterenol. Journal of Protozoology 32, 6-9.
9. Skriver, L. & Nilsson, J.R. (1978). The relationship between energy-dependent phagocytosis and the rate of oxygen consumption in Tetrahymena. Journal of General Microbiology 109, 359-366.
10. Jacobs, W.A. & Heidelberger, M.H. (1917). Acylation of aromatic aminocompounds and ureas. Journal of the American Chemical Society 39, 1442-1446
11. Jacobs, W.A. & Heidelberger, M.H. (1917). Alcylation of aromatic aminocompounds and ureas. Journal of the American Chemical Society 39, 2190-2194.
12. Jaeger, C.B. (1946). 2-Nitro-3-methoxyphenol. Chemical Abstracts 40, 1883.
13. Kimugawa, E.J., Ochiae, M.L. & Yamamoto, H.N. (1959). Fungicides. I. Synthesis and antifungal activity of 6-methoxy-2-benzonazoline. Yakugaku Zanhi 79, 931-935.
14. Marciykiewicz, D.S. (1961). O-Nitro derivatives of p-aryloxyphenols. Farmaceutyczny 52, 397-399.
15. Magin, C.T. & Fetterly, L.C. (1964). Treatment of allylphenols. (Shell Development Co., US 2391), Chemical Abstracts 61, 839-843.
16. Testa, B. & Salveson, B. (1980). Quantitative structure-activity relationship in drug metabolism and disposition: pharmaceutics of N-substituted amphetamines in humans. Journal of Pharmaceutical Sciences 69, 497-501.
17. Akber, S.F (1991). N-Isopropyl-1,2,3-p-iodoamphetamine uptake mechanism in the lung: is it dependent on pH, lipophilicity or pKa Nuklearmedizin 30, 294-296.
18. Pagou, M. & Koutselinis, A. (1993). Lipophilicity and chromatographic behavior of benzoic acid derivatives. Chemical and Pharmaceutical Bulletin 41, 319-324.
19. Rekker, R. & de Kort, H (1985). The Hydrophobic Fragmental Constant, an Extension to 1000 Datapoints (A Data Manual), pp. 1-87. Amsterdam: Amsterdam University Press.
20. Seaman, G.R. (1961). Some aspects of phagotrophy in Tetrahymena. Journal of Protozoology 8, 204-212.
21. Ricketts, T.R. (1971). Periodicity of endocytosis in Tetrahymena pyriformis. Protoplasma 73, 387-396.
22. Ricketts, T.R. & Rappitt, A.F. (1976). Endocytosis, digestive vacuolar movement and exocytosis on refeeding starved Tetrahymena pyriformis GL-9. Protoplasma 87, 221-236.
23. Nilsson, J.R. (1979). Phagotrophy in Tetrahymena. In Biochemistry and Physiology of Protozoa, 2nd Edn, Vol. 2 (ed. M. Levandowsky & S.H. Hutner), pp. 339-379. New York; Academic Press
24. Wu, C & Henry, J.A. (1994). Interaction between ethanol and opioids in a protozoan assay Human and Experimental Toxicology 13, 145-148.
25. Rosenberg, M D (1966) Intracellular transport In Intracellular Transport (ed. K.B. Warren), pp. 45-71 New York: Academic Press.
26. Ricketts, T.R. (1972). The induction of endocytosis in starved Tetrahymena pyriformis. Journal of Protozoology 19, 373-375
27. Ricketts, T.R (1983). Dichloroisoproterenol and digestive vacuolar formation, movement and egestion in Tetrahymena pyriformis GL-9. Protoplasma 115, 25-33.
28. Ricketts, T.R. (1971) Endocytosis in Tetrahymena pyriformis: the selectivity of uptake of particles and the adaptive increase in cellular acid phosphatase activity Experimental Cell Research 66, 49-58.
29. Hill, D.L. (1972) The Biochemistry and Physiology of Tetrahymena. In Cell Biology. A Series of Monographs (ed. D.E. Buetow, I.L. Cameron & G.M. Padilla), pp. 116-117 New York: Academic Press.
30. Iwata, H. & Kariya, K. (1973). Adrenergic mechanism in Tetrahymena. I. Changes in monoamine oxidase activity during growth. Experientia 29, 265-266.
31. Gurdersen, P. & Thompson, G. (1985). Further studies of dopamine metabolism and function in Tetrahymena. Journal of Protozoology 32, 25-31.
32. Theoharides, T. (1992). CNS drugs. In Pharmacology (ed. T. Theoharides), pp. 253-362. Boston, Toronto, London: Little, Brown & Co.
33. Christensen, A.V. (1981). Dopamine hyperactivity effects of neuroleptics alone and in combination with GABA-agonists. Biological Psychiatry 16, 828-831.
34. Lynch, M.R, Kuhn, H.G. & Carey, R.J. (1988). Chronic haloperidol-amphetamine interactions and mesolimbic dopamine. Neuropsychobiology 19, 97-103
35. Lilliemark, E., Lilliemark, J., Kallberg, N., Bjorkholm, M., Sjostrom, B. & Peterson, C. (1995). Studies of the organ distribution in mice of teniposide liposomes designed for treatment of diseases in the mononuclear phagocytic system Pediatric Research 38, 7-10.
36. Flaim, S F. (1994). Pharmakokinetics and sideeffects of perfluorocarbon-based blood substitutes. Artificial Cells, Blood Substitutes and Immobilization Biotechnology 22, 1043-1054.
37. Darvas, Z & Csaba, G. (1990) Dose-dependent impact of pretreatment (imprinting) with histamine and serotoiun on the phagocytic activity of Tetrahymena. Acta Microbiologica Hungarica 37, 285-287.
38. 1A agonists correlates with dopamine antagonist properties. Journal of Pharmacology and Experimental Therapeutics 268, 1297-1303
39. 1A agonists. Journal of Pharmacology and Experimental Therapeutics 273, 101-112.