The parathyroid hormone/parathyroid hormone-related peptide receptor in Jansen's metaphyseal chondrodysplasia

Current Opinion in Endocrinology and Diabetes

Volumn 4, Issue 6, 1997, Pages 433-442

  Jüppner, Harald ^a   Schipani, E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000926623     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-199712000-00009     Document Type: Article

References (8)

1. Jüppner H, Abou-Samra AB, Freeman MW, Kong XF, Schipani E, Richards J, Kolakowski LF Jr, Hock J, Potts JT Jr, Kronenberg HM, Segre GV: A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 1991, 254:1024-1026.
2. Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT Jr, et al.: Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A 1992, 89:2732-2736.
3. Schipani E, Karga H, Karaplis AC, Potts JT Jr, Kronenberg HM, Segre GV, Abou-Samra AB, Jüppner H: Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology 1993, 132:2157-2165.
4. Potts JT Jr, Bringhurst FR, Gardella TJ, Nussbaum SR, Segre GV, Kronenberg HM: Parathyroid hormone: physiology, chemistry, biosynthesis, secretion, metabolism, and mode of action. In Endocrinology. Edited by DeGroot LJ. Philadelphia: WB Saunders; 1996:920-965.
5. Abou-Samra AB, Uneno S, Jüppner H, Keutmann H, Potts JT Jr, Segre GV, Nussbaum SR: Non-homologous sequences of parathyroid hormone and the parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells. Endocrinology 1989, 125:2215-2217.
6. Caulfield MP, Rosenblatt M: Parathyroid hormone-receptor interactions. Trends Endocrinol Metab 1990, 2:164-168.
7. Usdin TB, Gruber C, Bonner TI: Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. J Biol Chem 1995, 270:15455-15458.
8. Gardella TJ, Luck MD, Jensen GS, Usdin TB, Jüppher H: Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist J Biol Chem 1996, 271:19888-19893. The PTH-2 receptor is activated by PTH, but only poorly or not at all by PTHrP. The article shows that the substitution of a single amino acid residue, trypophan instead of phenylalanine at position 23, dramatically enhances the binding affinity of PTHrP for the PTH-2 receptor; replacement of histidine by isoleucine at position 5 turns PTHrP into a full agonist at the PTH-2 receptor.