Facile three-component coupling procedure for the synthesis of substituted tetrahydroisoindole-1,3-diones from α,β-unsaturated aldehydes

Organic Letters

Volumn 3, Issue 18, 2001, Pages 2895-2898

  Von Wangelin, Axel Jacobi ^a   Neumann, Helfried ^a   Gördes, Dirk ^a   Spannenberg, Anke ^a   Beller, Matthias ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

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EID: 0000759596     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0101436     Document Type: Article

References (28)

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11. Neumann, H.; Jacobi von Wangelin, A.; Gördes, D.; Spannenberg, A.; Beller, M. J. Am. Chem. Soc. 2001 in press.
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24. A complete reaction scheme would also involve several other equilibrating species, such as imines, aminals, and 1,3-bis(acylamino)-but-1-ene derivatives, as well as σ and π bond rotamers. See ref 5.
25. A solid-phase approach toward hydroxy-substituted tetrahydroisoindole-1,3-diones involving silyldienol ether substrates has recently been reported: Smith, E. M. Tetrahedron Lett. 1999, 40, 3285.
26. Spannenberg, A.; Neumann, H.; Jacobi von Wangelin, A.; Gördes, D.; Beller, M. Unpublished results.
27. Traces of elimination product (dihydroisoindole-1,3-dione) were detected.
28. 2 (all data) = 0.111, 211 parameters