Determination of the Enantiomers of Mianserin and its Metabolites in Plasma by Capillary Electrophoresis after Liquid-Liquid Extraction and On-Column Sample Preconcentration

Journal of Chromatographic Science

Volumn 35, Issue 7, 1997, Pages 315-320

  Eap, Chin B ^a   Powell, Kerry ^a   Baumann, Pierre ^a  

^a DEPT UNIV DE PSYCHIATRIE ADULTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000666640     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/35.7.315     Document Type: Article

References (7)

1. E.J. Begg, J.R. Sharman, J.E. Kidd, R. Sainsbury, and D.W.J. Clark. Variability in the elimination of mianserin in elderly patients. Br. J. Clin. Pharmacol. 27: 445-51 (1989).
2. R.M. Pinder and A.M.L van Delft. Pharmacological aspects of mianserin. Acta Psychiatr. Scand. 302: 59-71 (1983).
3. C.B. Eap, K. Powell, D. Campus-Souche, C. Monney, D. Baettig, W. Taeschner, and P. Baumann. Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients. Chirality 6: 555-63 (1994).
4. R.L. Chien and D.S. Burgi. On-column sample concentration using field amplification in CZE. Anal. Chem. 64: 489-96 (1992).
5. U. Bondesson and L.H. Lindström. Determination of clozapine and its N-demethylated metabolite in plasma by use of gas chromatography-mass spectrometry with single ion detection. Psychopharmacology 95: 472-75 (1988).
6. I. Bechet, P. Paques, M. Fillet, P. Hubert, and J. Crommen. Chiral separation of basic drugs by capillary zone electrophoresis with cyclodextrin additives. Electrophoresis 15: 818-23 (1994).
7. A. Souche, P. Baumann, L. Koeb, P. Thermoz, J.M. Azorin, and H. Dufour. Traitement de la dépression par l'association de la domipramine et de la triiodothyronine (LT3). L'Encephale 17: 37-42 (1991).