An Improved Synthesis of 1-(1,2,3,6-Tetrahydro-1-methyl-4- Pyridinyl)ethanone, Isoarecolone

Journal of Heterocyclic Chemistry

Volumn 34, Issue 6, 1997, Pages 1861-1863

  Beach, J Warren ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000653272     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570340637     Document Type: Article

References (15)

1. D. A. Flynn and D. C. Mash, J. Neurochem., 47, 1948 (1986).
2. P. J. Whitehouse, A. M. Martino, P. G. Antuono, P. Lowenstein, J. T. Coyle, D. L. Price and K. J. Kellar, Brain Res., 371, 146 (1986).
3. E. K Perry, R. H. Perry, C. J. Smith, D. J. Dick, J. M. Candy, J. A. Edwardson, A. Fairbaim and G. Blessed, J. Neurol. Neurosurg. Psychiatry, 50, 806 (1987).
4. E. Giacobini, P. DeSarno, B. Clark and M. McIlhany, in Progress in Brain Research, A Nordberg, ed, Elsevier, Amsterdam, 1989, pp 335-343.
5. E. D. Levin, Psychopharmacology, 108, 417 (1992).
6. P. Whiteaker, H. S. Garcha, S. Wonnacott and I. P. Stolerman, Brit. J. Pharmacol., 116, 2097 (1995).
7. N. R. Mirza, Q. Pei, I. P. Stolerman and T. S. C. Zetterstrom, Eur. J. Pharmacol., 295, 207 (1996).
8. C. Reavill, C. E. Spivak, I. P. Stolerman and J. A.Waters, Neuropharmacology, 26, 789 (1987).
9. J. A. Waters, C. E. Spivak, M. Hermsmeir, J. S. Yadav, R. F. Liang and T. M Gund,. J. Med. Chem., 31, 545 (1988).
10. C. E. Spivak, T. M. Gund, R. F. Liang and J. A.Waters, Eur. J. Pharmacol., 120, 127 (1986).
11. J. S. Ward and L. Merritt, J. Heterocyclic Chem., 27, 1709 (1990).
12. S. Nahm and S. M. Wienreb Tetrahedron Letters, 22, 3815 (1981).
13. D. L. Coffen, U. Hengarter, D. A. Kalonak, M. E. Mulligan, D. C. Burdick, G. L. Obon and L. J. Todaro. J. Org. Chem., 49, 5109 (1984).
14. [14a] Recrystallized from 2-propanol.
15. [14b] Recrystallized from acetone and absolute ethanol.