메뉴 건너뛰기




Volumn 14, Issue 4, 1999, Pages 307-317

Application of artificial intelligence and computer-based methods to predicting chemical toxicity

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; COMPUTATIONAL METHODS; DNA; EXTRAPOLATION; GENES; HEALTH RISKS; NEURAL NETWORKS; RISK ASSESSMENT; TOXICITY; TUMORS;

EID: 0000608085     PISSN: 02698889     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0269888999004038     Document Type: Article
Times cited : (16)

References (29)
  • 2
    • 0030941637 scopus 로고    scopus 로고
    • Computational predictive programs (expert systems) in toxicology
    • Benfenati E and Gini G, 1997, "Computational predictive programs (expert systems) in toxicology" Toxicology 119 213-225.
    • (1997) Toxicology , vol.119 , pp. 213-225
    • Benfenati, E.1    Gini, G.2
  • 3
    • 0030755884 scopus 로고    scopus 로고
    • The first US National Toxicology Program exercise on the prediction of rodent carcinogenicity: Definitive results
    • Benigni R, 1997, "The first US National Toxicology Program exercise on the prediction of rodent carcinogenicity: definitive results" Mutation Research 387(1) 35-45.
    • (1997) Mutation Research , vol.387 , Issue.1 , pp. 35-45
    • Benigni, R.1
  • 4
    • 0031904573 scopus 로고    scopus 로고
    • QSAR models for discriminating between mutagenic and nonmutagenic aromatic and heteroaromatic amines
    • Benigni R, Passerini L, Gallo G, Giorgi F and Cotta-Ramusino M, 1998, "QSAR models for discriminating between mutagenic and nonmutagenic aromatic and heteroaromatic amines" Environ Mol Mutagen 32(1) 75-83.
    • (1998) Environ Mol Mutagen , vol.32 , Issue.1 , pp. 75-83
    • Benigni, R.1    Passerini, L.2    Gallo, G.3    Giorgi, F.4    Cotta-Ramusino, M.5
  • 5
    • 0031698019 scopus 로고    scopus 로고
    • Quantitative structure-based modeling applied to the characterization and prediction of chemical toxicity
    • Benigni R and Richard AM, 1998. "Quantitative structure-based modeling applied to the characterization and prediction of chemical toxicity" Methods: A Companion to Methods in Enzymology 14 264-276.
    • (1998) Methods: A Companion to Methods in Enzymology , vol.14 , pp. 264-276
    • Benigni, R.1    Richard, A.M.2
  • 6
    • 0029850743 scopus 로고    scopus 로고
    • The NIEHS Predictive-Toxicology Evaluation Project: Chemcarcinogenicity bioassays
    • Bristol DW, Wachsman JT and Greenwell A, 1996, "The NIEHS Predictive-Toxicology Evaluation Project: Chemcarcinogenicity bioassays" Environ Health Perspect 104S(5) 1001-1010 (http:// www.comlab.ox.ac.uk/ou cl/groups/machlearn/PTE/)
    • (1996) Environ Health Perspect , vol.104 S , Issue.5 , pp. 1001-1010
    • Bristol, D.W.1    Wachsman, J.T.2    Greenwell, A.3
  • 7
    • 84995114627 scopus 로고
    • The use of artificial intelligence systems for predicting toxicity
    • Combes RD and Judson P, 1995, "The use of artificial intelligence systems for predicting toxicity" Pestic Science 45 179-194.
    • (1995) Pestic Science , vol.45 , pp. 179-194
    • Combes, R.D.1    Judson, P.2
  • 10
    • 0027954402 scopus 로고
    • Use of SAR in computer-assisted prediction of carcinogenicity and mutagenicity of chemicals by the TOPKAT program
    • Enslein K, Gombar VK and Blake BW, 1994, "Use of SAR in computer-assisted prediction of carcinogenicity and mutagenicity of chemicals by the TOPKAT program" Mutation Research 305 47-61.
    • (1994) Mutation Research , vol.305 , pp. 47-61
    • Enslein, K.1    Gombar, V.K.2    Blake, B.W.3
  • 13
    • 0026342471 scopus 로고
    • The Carcinogenic Potency Database: Analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program
    • Gold LS, Slone TH, Manley NB, Garfinkel GB, Hudes ES, Rohrbach L and Ames BN, 1991, "The Carcinogenic Potency Database: Analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program" Environ Health Perspect 96 11-5 (http://potency.berkeley.edu/hybrid.html)
    • (1991) Environ Health Perspect , vol.96 , pp. 11-15
    • Gold, L.S.1    Slone, T.H.2    Manley, N.B.3    Garfinkel, G.B.4    Hudes, E.S.5    Rohrbach, L.6    Ames, B.N.7
  • 14
    • 0000903415 scopus 로고    scopus 로고
    • Computer software for risk assessment
    • Greene N, 1996, "Computer software for risk assessment" J Chem Inf Comput Sci 37 148-150.
    • (1996) J Chem Inf Comput Sci , vol.37 , pp. 148-150
    • Greene, N.1
  • 15
    • 0025363159 scopus 로고
    • Risk assessment of carcinogenic and noncarcinogenic chemicals
    • Johannsen FR, 1990, "Risk assessment of carcinogenic and noncarcinogenic chemicals" Crit Rev Toxicol 20 (5) 341-367.
    • (1990) Crit Rev Toxicol , vol.20 , Issue.5 , pp. 341-367
    • Johannsen, F.R.1
  • 16
    • 0029824974 scopus 로고    scopus 로고
    • Prediction of rodent carcinogenicity bioassays from molecular structure using inductive logic programming
    • King RD and Srinivasan A, 1996, "Prediction of rodent carcinogenicity bioassays from molecular structure using inductive logic programming" Environ Health Perspect 104S(5) 1031-1040.
    • (1996) Environ Health Perspect , vol.104 S , Issue.5 , pp. 1031-1040
    • King, R.D.1    Srinivasan, A.2
  • 17
    • 0028157137 scopus 로고
    • Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTI-CASE
    • Klopman G and Rosenkranz HS, 1994, "Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTI-CASE" Mutation Research 305 33-46.
    • (1994) Mutation Research , vol.305 , pp. 33-46
    • Klopman, G.1    Rosenkranz, H.S.2
  • 18
    • 0029850561 scopus 로고    scopus 로고
    • Carcinogenicity predictions for a group of 30 chemicals undergoing rodent cancer bioassays based on rules derived from subchronic organ toxicities
    • Lee Y, Buchanan, BG and Rosenkranz HS, 1996, "Carcinogenicity predictions for a group of 30 chemicals undergoing rodent cancer bioassays based on rules derived from subchronic organ toxicities" Environ Health Perspect 104S(5) 1059-1063.
    • (1996) Environ Health Perspect , vol.104 S , Issue.5 , pp. 1059-1063
    • Lee, Y.1    Buchanan, B.G.2    Rosenkranz, H.S.3
  • 19
    • 0031785668 scopus 로고    scopus 로고
    • A combined COMPACT and HazardExpert study of 40 chemicals for which information on mutagenicity and carcinogenicity is known, including the results of human epidemiological studies
    • Lewis DF, Ioannides C and Parke DV, 1998, "A combined COMPACT and HazardExpert study of 40 chemicals for which information on mutagenicity and carcinogenicity is known, including the results of human epidemiological studies" Hum Exp Toxicol 17(10) 577-586.
    • (1998) Hum Exp Toxicol , vol.17 , Issue.10 , pp. 577-586
    • Lewis, D.F.1    Ioannides, C.2    Parke, D.V.3
  • 20
    • 0030580221 scopus 로고    scopus 로고
    • Structure-activity and mechanistic relationships: The effect of chemical overlap on structural overlap in data bases of varying size and composition
    • Liu M, Sussman N, Klopman G and Rosenkranz HS, 1996, "Structure-activity and mechanistic relationships: the effect of chemical overlap on structural overlap in data bases of varying size and composition" Mutation Research 372(1) 79-85.
    • (1996) Mutation Research , vol.372 , Issue.1 , pp. 79-85
    • Liu, M.1    Sussman, N.2    Klopman, G.3    Rosenkranz, H.S.4
  • 21
    • 0032565550 scopus 로고    scopus 로고
    • Structure-based methods for predicting mutagenicity and carcinogenicity: Are we there yet?
    • Richard AM, 1998a, "Structure-based methods for predicting mutagenicity and carcinogenicity: are we there yet?" Mutation Research 400(1-2) 493-507.
    • (1998) Mutation Research , vol.400 , Issue.1-2 , pp. 493-507
    • Richard, A.M.1
  • 22
    • 0032435458 scopus 로고    scopus 로고
    • Commercial toxicity prediction systems: A regulatory perspective
    • Richard AM, 1998b, "Commercial toxicity prediction systems: A regulatory perspective" Toxicology Letters 102-103 611-616.
    • (1998) Toxicology Letters , vol.102-103 , pp. 611-616
    • Richard, A.M.1
  • 23
    • 0025863682 scopus 로고
    • Computer prediction of possible toxic action from chemical structure; the DEREK system
    • Sanderson DM and Earnshaw CG, 1991, "Computer prediction of possible toxic action from chemical structure; the DEREK system" Human & Exper Toxicol 10 261-273.
    • (1991) Human & Exper Toxicol , vol.10 , pp. 261-273
    • Sanderson, D.M.1    Earnshaw, C.G.2
  • 24
    • 0032538603 scopus 로고    scopus 로고
    • Microchip arrays put DNA on the spot
    • Service RF, 1998, "Microchip arrays put DNA on the spot" Science 282 396-399.
    • (1998) Science , vol.282 , pp. 396-399
    • Service, R.F.1
  • 26
    • 0028534522 scopus 로고
    • META. 2. A dictionary model of mammalian xenobiotic metabolism
    • Talafous J, Sayre LM, Mieyal JJ and Klopman G, 1994, "META. 2. A dictionary model of mammalian xenobiotic metabolism" J Chem Inf Comput Sci 34(6) 1326-1333.
    • (1994) J Chem Inf Comput Sci , vol.34 , Issue.6 , pp. 1326-1333
    • Talafous, J.1    Sayre, L.M.2    Mieyal, J.J.3    Klopman, G.4
  • 27
    • 0030913346 scopus 로고    scopus 로고
    • Methods for predicting carcinogenic hazards: New opportunities coming from recent developments in molecular oncology and SAR studies
    • Taningher M, Malacarne D, Mancuso T, Peluso M, Pescarolo MP and Parodi S, 1997, "Methods for predicting carcinogenic hazards: new opportunities coming from recent developments in molecular oncology and SAR studies" Mutation Research 391(1-2) 3-32.
    • (1997) Mutation Research , vol.391 , Issue.1-2 , pp. 3-32
    • Taningher, M.1    Malacarne, D.2    Mancuso, T.3    Peluso, M.4    Pescarolo, M.P.5    Parodi, S.6
  • 28
    • 0030701583 scopus 로고    scopus 로고
    • Challenge to the simple paradigm that 'carcinogens' are 'mutagens' and to the in vitro and in vivo assays used to test the paradigm
    • Trosko JE, 1997, "Challenge to the simple paradigm that 'carcinogens' are 'mutagens' and to the in vitro and in vivo assays used to test the paradigm" Mutation Research 373(2) 245-249.
    • (1997) Mutation Research , vol.373 , Issue.2 , pp. 245-249
    • Trosko, J.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.