Sensitivity analysis and the design of gas uptake inhalation studies

Inhalation Toxicology

Volumn 7, Issue 7, 1995, Pages 1075-1094

  Evans, Marina V ^a   Andersen, Melvin E ^a,b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b KS Crump Division ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000593892     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.3109/08958379509002568     Document Type: Article

References (17)

1. The use of inhalation techniques to assess the kinetic constants of 1, 1-dichloroethylene metabolism
2. Inhalation pharmacokinetics: Evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood: inhaled air concentration ratios
3. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride
4. Quantitative evaluation of the metabolic interactions between trichloroethylene and 1, 1-dichloroethylene in vivo using gas uptake methods
5. Development of a physiologically based pharmacokinetic model for chloroform
6. Applications of sensitivity analysis to a physiologically-based pharmacokinetic model for carbon tetrachloride in rats
7. Pharmacokinetics of halogenated ethylenes in rats
8. Inhalation pharmacokinetics based on gas uptake studies. I. Improvement of kinetic models
9. A physiologically based simulation approach for determining metabolic constants from gas uptake data
10. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues
11. Gas uptake inhalation techniques and the rates of metabolism of chloromethanes, chloroethanes, and chloroethylenes in the rat
12. Sensitivity analysis for physiologically-based pharmacokinetic models
13. Species differences in the production and clearance of 1, 3-buta-diene metabolites: A mechanistic model indicates predominantly physiological, not biochemical, control
14. A physiologically based pharmacokinetic model for inhaled carbon tetrachloride
15. A physiologically based description of the inhalation pharmacokinetics of styrene monomer in rats and humans
16. Physiologically based pharmacokinetic modeling with methylchloroform: Implications for interspecies, high dose/low dose, and dose route extrapolations
17. Some interpretive aspects of elementary sensitivity gradients in combustion kinetics modeling