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Our earlier synthesis of 1, 4-dichloro-2, 2, 3, 3-tetramethylbutane by the iodine-promoted coupling of ethyl 2-methylpropionate proved difficult to scale up because dilute conditions and low temperatures were required to avoid undesired Claisen condensation of the lithium enolate and the starting aldehyde. See Brocksom, T. J.; Petragnani, N.; Rodriguez, R.; La Scalla Teixeira, H. Synthesis 1975, 396–397
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Our earlier synthesis of 1, 4-dichloro-2, 2, 3, 3-tetramethylbutane by the iodine-promoted coupling of ethyl 2-methylpropionate proved difficult to scale up because dilute conditions and low temperatures were required to avoid undesired Claisen condensation of the lithium enolate and the starting aldehyde. See: Sowinski, A. F.; Whitesides, G. M. J. Org. Chem. 1979, 44, 2369–2376. Brocksom, T. J.; Petragnani, N.; Rodriguez, R.; La Scalla Teixeira, H. Synthesis 1975, 396–397.
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