Three-dimensional structure of peptide-protein complexes: implications for recognition

Current Opinion in Structural Biology

Volumn 2, Issue 6, 1992, Pages 904-919

  Marshall, Garland R ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000548829     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-440X(92)90117-P     Document Type: Article

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6. A Crystal Molecular Conformation of Leucine-enkephalin Related to the Morphine Molecule
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14. Concepts and Progress in the Design of Peptide Mimetics — β Turns and Thyrotropin Releasing Hormone
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16. Synthesis and Biological Activity of Some Pseudo-peptide Analogues of Tetragastrin the Importance of the Peptide Backbone
17. Phenylethylamide Derivatives of the C-terminal Tetrapeptide of Gastrin
18. Probing Peptide Backbone Function in Bombesin
19. Isosteric Analogs of Growth Hormone-releasing Factor
20. 2NH)Phe-Pro-Gly-OH
21. Synthesis and Biological Activities of Pseudopeptide Analogues of the C-terminal Heptapeptide of Cholecystokinin. On the Importance of the Peptide Bonds
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23. Evidence for Receptor-bound Turn Conformations of Bradykinin and Angiotensin II
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30. Aspects of Molecular Recognition: Solvent Exclusion and Dimerization of the Antibiotic Ristocetin when Bound to a Model Bacterial Cell-wall Precursor
31. Towards the Semiquantitative Estimation of Binding Constants for Peptide-Peptide Binding in Aqueous Solution
32. Chemistry and Biology of the Immunophilins and their Immunosuppressive Ligands
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34. A Model of the Cyclophilin/Cyclosporin A (CsA) Complex from NMR and X-ray Data Suggests that CsA Binds as a Transition-state Analogue
35. The NMR Structure of Cyclosporin A Bound to Cyclophilin in Aqueous Solution
36. Cyclosporin-A-Cyclophilin Complex Formation — a Model Based on X-ray and NMR Data
37. Novel Backbone Conformation of Cyclosporin A: the Complex with Lithium Chloride
38. Lithium Chloride Perturbation of cis-trans Peptide Bond Equilibria Effect of Conformational Equilibria in Cyclosporin A and on Time-dependent Inhibition of Cyclophilin
39. Structure of Human Cyclophilin and its Binding Site for Cyclosporin A Determined by X-ray Crystallography and NMR Spectroscopy
40. Cyclophilin Binds to the Region of Cyclosporin Involved in its Immunosuppressive Activity
41. A Conformation of Cyclosporin A in Aqueous Environment Revealed by the X-ray Structure of a Cyclosporin-Fab Complex
42. Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition
43. Structure Function and Properties of Antibody Binding Sites
44. Crystal Structures of an Antibody to a Peptide and its Complex with Peptide Antigen at 2.8 Å
45. Structural Aspects of Antibodies and Antibody-Antigen Complexes
46. Three-dimensional Structure of an Angiotensin II-Fab Complex at 3 Å: Hormone Recognition by an Anti-idiotypic Antibody
47. Three-dimensional Structure of an Idiotope-Anti-idiotope Complex
48. Recognition of Angiotensin II: Antibodies at Different Levels of an Idiotypic Network Are Superimposable
49. Antigen Mobility in the Combining Site of an Antipeptide Antibody
50. Synthetic Site-directed ligands
51. Interaction between Immunogenic Peptides and MHC Proteins
52. Identification of Self Peptides Bound to Purified HLA-B27
53. The Structure of HLA-B27 Reveals Nonamer Self-peptides Bound in an Extended Conformation
54. The Three-dimensional Structure of HLA-B27 at 21 Å Resolution suggests a General Mechanism for Tight Peptide Binding to MHC
55. Peptide Binding to the Major Histocompatibility Molecules
56. b
57. Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules
58. A Critical Role for Conserved Residues in the Cleft of HLA-A2 in Presentation of a Nonapeptide to T cells
59. A Hypothetical Model of the Foreign Antigen Binding Site of Class II Histocompatibility Molecules
60. Identification of the T-cell and Ia Contact Residues of a T-cell Antigenic Epitope
61. Recognition of the HLA Class II-peptide Complex by the T-cell Receptor: Reversal of Major Histocompatibility Complex Restriction of a T-cell Clone by a Point Mutation in the Peptide Determinant
62. Sequence Analysis of Peptides Bound to MHC Class II Molecules
63. Self and Foreign Peptides Interact with Intact and Disassembled MHC Class II Antigen HLA-DR Via Tryptophan Pockets
64. Human Leukocyte and Porcine Pancreatic Elastase. X-ray Crystal Structures, Mechanisms, Substrate Specificity, and Mechanism-based Inhibitors
65. Conserved Folding in Retroviral Proteases: Crystal Structure of a Synthetic HIV-1 Protease
66. Crystal Structure of a Retroviral Protease Proves Relationship to Aspartic Protease Family
67. Three-dimensional Structure of Aspartyl Protease from Human Immunodeficiency Virus HIV-1
68. The Three-dimensional Structure of the Aspartyl Protease from the HIV-1 Isolate BRU
69. Structure of Complex of Synthetic HIV-1 Protease with a Substrate-based Inhibitor at 2.3 Å Resolution
70. Structure and Function of Retroviral Proteases
71. A Cumulative Specificity Model for Proteases from Human Immunodeficiency Virus Types 1 and 2, Inferred from Statistical Analysis of an Extended Substrate Database
72. Analysis of Retroviral Protease Cleavage Sites Reveals Two Types of Cleavage Sites and the Structural Requirements of the P1 Amino Acid
73. Analysis of the Subsite Preferences of HIV-1 Proteinase Using MA/CA Junction Peptides Substituted at the P3-P1′ Positions
74. 3′ Subsites of HIV Proteinases
75. Converting Trypsin to Chymotrypsin: the Role of Surface Loops
76. Design, Activity, and 2.8 Å Crystal Structure of a C2 Symmetric Inhibitor Complexed to HIV-1 Protease
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78. Novel Binding Mode of Highly Potent HIV-proteinase Inhibitors Incorporating the (R)-Hydroxyethylamine Isostere
79. Structure at 2.5 Å Resolution of Chemically Synthesized Human Immunodeficiency Virus Type 1 Protease Complexed with a Hydroxyethylene-based Inhibitor
80. Crystallographic Analysis of a Complex between Human Immunodeficiency Virus Type 1 Protease and Acetyl-pepstain at 2.0 Å Resolution
81. 2 Symmetry
82. Structure-based Design of Nonpeptide Inhibitors Specific for the Human Immunodeficiency Virus 1 Protease
83. Inhibition of the HIV-1 Protease by Analogs of Haloperidol
84. Structure-based Strategies for Drug Design and Discovery
85. Effect of Hydroxyl Group Configuration in Hydroxethylamine Dipeptide Isosteres on HIV Protease Inhibitors. Evidence for Multiple Binding Modes
86. Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-dependent Protein Kinase
87. Investigation of an Octapeptide Inhibitor of Escherichia coli Ribonucleotide Reductase by Transferred Nuclear Overhauser Effect Spectroscopy
88. The Three-dimensional Structure of Class P Glutathione S-transferase in Complex with Glutathione Sulfonate at 2.3 Å Resolution
89. Three-dimensional Structure of Echistatin, the Smallest Active RGD Protein
90. Development of a Small RGD Peptide Fibrinogen Receptor Antagonist with Potent Antiaggregatory Activity in vitro
91. Cyclic RGD Peptide Analogues as Antiplatelet Antithrombotics
92. Reevaluating Equilibrium and Kinetic Binding Parameters for Lipophilic Drugs Based on a Structural Model for Drug Interaction with Biological Membranes
93. Peptide-Membrane Interactions and a New Principle in Quantitative Structure-Activity Relationships
94. Molecular Design of Transmembrane Ion Channels
95. Conformational Studies by Circular Dichroism, H-1-NMR, and Computer Simulations of Bombolitin-I and Bombolitin-III in Aqueous Solution Containing Surfactant Micelles
96. Transferred Nuclear Overhauser Effect Analyses of Membrane-bound Enkephalin Analogues by 1H Nuclear Magnetic Resonance: Correlation between Activities and Membrane-bound Conformations
97. Tyrosine Alone Exhibits Opiate-like Activity when Linked to an Amphipathic Hydrocarbon Chain
98. Different Conformations for the Same Polypeptide Bound to Chaperones DnaK and GroEL
99. Different Conformations for the Same Polypeptide Bound to Chaperones DnaK and GroEL
100. Solution Structure of a Calmodulin-Target Peptide Complex by Multidimensional NMR
101. Target Enzyme Recognition by Calmodulin: 2.4 Å Structure of a Calmodulin-Peptide Complex
102. Deciphering the Structural Elements of Hirudin C-terminal Peptide that Bind to the Fibrinogen Recognition Site of α-Thrombin
103. The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin
104. Crystal Structure of the Thrombin-Hirudin Complex: a Novel Mode of Serine Protease Inhibition
105. Conformation of Recombinant Desulfatohirudin in Aqueous Solution Determined by Nuclear Magnetic Resonance
106. Conformational Stability of a Thrombin-binding Peptide Derived from the C-terminus
107. The Structure of Residues 7–16 of the Aα-Chain of Human Fibrinogen Bound to Bovine Thrombin at 2.3 Å Resolution
108. High-resolution NMR of Fibrinogen-like Peptides in Solution: Structure of a Thrombin-bound Peptide Corresponding to Residues 7–16 of the Aα-Chain of Human Fibrinogen
109. The Refined 1.9 Å X-ray Crystal Structure of d-Phe-Pro-Arg-Chloromethylketone-inhibited Human α-Thrombin: Structural Analysis, Overall Structure, Electrostatic Properties, Detailed Active-site Geometry and Structure-Function Relationships
110. Conformational Constraints: Nonpeptide β-Turn Mimics
111. Peptide Mimetics of the Thrombin-bound Structure of Fibrinopeptide A
112. Major Enhancement of the Affinity of an Enzyme for a Transition-state Analog by a Single Hydroxyl Group
113. Conformational Analysis and Helical Preferences of Normal and α,α-Dialkyl Amino Acids
114. Helical Transitions in Peptides
115. Hemoglobin as a Receptor of Drugs and Peptides: X-ray Studies of the Stereochemistry of Binding
116. Nuclear Magnetic Resonance Studies of Flexible Opiate Conformations at Monoclonal Antibody Binding Sites