A one-pot, two-step synthesis of tetrahydro asterriquinone E

Organic Letters

Volumn 1, Issue 3, 1999, Pages 431-433

  Harris Jr , G Davis ^a   Nguyen, Ann ^a   App, Harald ^a   Hirth, Peter ^a   McMahon, Gerald ^a   Tang, Cho ^a  

^a SUGEN INC   (United States)

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EID: 0000546703     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990075b     Document Type: Article

References (24)

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12. After submission of this paper for publication, an article appeared in which a closely related, naturally occurring asterriquinone is described as an insulin mimetic with antidiabetic activity: Zhang, B.; Salituro, G.; Szalkowski, D.; Li, Z.; Zhang, Y.; Royo, I.; Vilella, D.; Diez, M. T.; Pelaez, F.; Ruby, C.; Kendall, R. L.; Mao, X.; Griffin, P.; Calaycay, J.; Zierath, J. R.; Heck, J. V.; Smith, R. G.; Moller, D. E. Science 1999, 284, 974.
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23. Publication in progress.
24. Hydrolysis of pure 8 under the same conditions gave a complex mixture containing none of the dihydroxy compound 9 (Scheme 3).