A new lithium alkoxide accelerated diastereoselective cyanation of ketones

Organic Letters

Volumn 3, Issue 4, 2001, Pages 553-556

  Wilkinson, H Scott ^a   Grover, Paul T ^a   Vandenbossche, Charles P ^a   Bakale, Roger P ^a   Bhongle, Nandkumar N ^a   Wald, Stephen A ^a   Senanayake, Chris H ^a  

^a SUNOVION PHARMACEUTICALS INC   (United States)

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ARTICLE;

EID: 0000532024     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0069608     Document Type: Article

References (28)

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19. 2, MTBE, and toluene can be use in this reaction. Preferred solvent is dry THF. It is important to note that premising LiOR and TMSCN is critical before addition of ketone or aldehyde.
20. Sodium and potassium salt of TGMM were generated upon treatment of NaH and KH with TGMM, respectively. MgTGMM was produced simply by treatment of TGMM with EtMgBr.
21. Available from Aldrich as a 1 M THF solution.
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