Modulation of vascular responsiveness by steroids

Current Opinion in Endocrinology and Diabetes

Volumn 4, Issue 6, 1997, Pages 392-400

  Clark, Kenneth E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000503724     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-199712000-00003     Document Type: Article

References (13)

1. Clark KE, Kopemik G: Vascular effects of estrogen and progesterone. Curt Opin Endocrinol Diabetes 1996, 3:483-489.
2. Ignarro LJ: Endothelium-derived nitric oxide: actions and properties. FASEB J 1989, 3:31-36.
3. Palmer RMJ, Ashton DS, Moncada S: Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988, 333:664-666.
4. Palmer RMJ, Ashton DS, Moncada S: Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988, 333:664-666.
5. Rees DD, Palmer RMJ, Schulz R, Hodson HF, Moncada S: Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990, 101:746-752.
6. g-nitro arginine (I-NOARG) a novel, I-arginine-reversible inhibitor of endothelium-dependent vasodilatation In vitro. Br J Pharmacol 1990, 99:408-412.
7. De Nucci G, Thomas R, D'Orleans-Juste P, Antures E, Walder C, Warner TD, Vane JR: Presser effects of circulating endothelin are limited by its removal In the pulmonary circulation and release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci USA 1988, 85:9797-9800.
8. Dainty IA, McGrath JC, Spedding M, Templeton AGB: The influence of the initial stretch and the agonist-induced tone on the effect of basal and stimulated release of EDRF. Br J Pharmacol 1990, 100:767-773.
9. Van Buren G, Yang DS, Clark KE: Estrogen-induced uterine vasodilation is inhibited by t-nitroarginine methyl ester an inhibitor of nitric oxide synthesis. Am J Obstet Gynecol 1992, 167:828-833.
10. Yang DS, Baker RS, Clark KE: Estrogen-induced Increases In uterine blood flow are mediated by Inducible nitric oxide In nonpregnant sheep (abstract). J Soc Gynecol Invest 1996, 3:280A.
11. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S: Induction of calcium-dependent nitric oxide synthase by sex hormones. Proc Natl Acad Sci USA 1994, 91:5212-5216.
12. 3 concentrations were highest during the estrogen-only phase of HRT and lost the observed significance during the estrogen-progesterone phase of HRT. These results suggest that chronic estrogen therapy increases NO synthesis and that progesterone antagonizes this effect.
13. Fritsch M, Anderson I, Leary CM, Gorski J: Two populations of the estrogen receptor separated and characterized using aqueous two-phase partitioning. Biochemistry 1997, 6:6230-6242. Reports that two populations of estrogen receptors can be found in the rat uterus. One is the unoccupied cytosolic estrogen receptor and the second is formed following estrogen binding or heating the first one to 30° C. It is not clear how these estrogen receptors differ functionally.