Bcr-Abl-mediated resistance to apoptosis is independent of PI 3-kinase activity

Cell Death and Differentiation

Volumn 4, Issue 7, 1997, Pages 548-554

  Amarante Mendes, Gustavo P ^a   Jascur, Thomas ^a   Nishioka, Walter K ^a   Mustelin, Tomas ^a   Green, Douglas R ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Apoptosis; Bcr Abl; Oncogene; Pl3 kinase

Indexed keywords

EID: 0000481827     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400276     Document Type: Article

References (18)

1. Afar DE, Goga A, McLaughlin J, Witte ON and Sawyers CL (1994) Differential complementation of Bcr-Abl point mutants with c-Myc. Science 264: 424-426
2. L.
3. Bedi A, Zehnbauer BA, Barber JP, Sharkis SJ and Jones RJ (1994) Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood 83: 2038-2044
4. Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B, Shoelson S and Cantley LC (1993) Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J. Biol. Chem. 268: 9478-9483
5. Gotoh A, Miyazawa K, Ohyashiki K and Toyama K (1994) Potential molecules implicated in downstream signaling pathways of p185BCR-ABL in Ph+ ALL involve GTPase-activating protein, phospholipase C-gamma 1, and phosphatidylinositol 3′-kinase. Leukemia 8: 115-120
6. Harrison Findik D, Susa M and Varticovski L (1995) Association of phosphatidilinositol 3-kinase with SHC in chronic myelogenous leukemia cells. Oncogene 10: 1385-1391
7. Kelliher MA, McLaughlin J, Witte ON and Rosenberg N (1990) Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc. Natl. Acad. Sci. USA 87: 6649-6653
8. Kulik G, Klippel A and Weber MJ (1997) Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17: 1595-1606
9. Laneuville P, Timm M and Hudson AT (1994) bcr/abl expression in 32D cl3(G) cells inhibits apoptosis induced by protein tyrasine kinase inhibitors. Cancer Res. 54: 1360-1366
10. Minshall C, Arkins S, Freund GG and Kelley KW (1996) Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor. J. Immunol. 156: 939-947
11. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139: 271-279
12. c-src complexes, and PI3-kinase. Cell 65: 91-104
13. Panayotou G and Waterfiel MD (1993) The assembly of signalling complexes by receptor tyrosine kinases. Bioessays 15: 171-177
14. Parker, P and Waterfield, MD (1992) Phosphatidylinositol 3-kinase: a novel effector. Cell Growth Differ. 3: 747-752
15. Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen S-C, Zon G, Gewirtz AM, Perussia B and Calabretta B (1995) Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood 86: 726-736
16. Smetsers TF, Skorski T, van de Locht LT, Wessels HM, Pennings AH, de Witte T, Calabretta B and Mensink EJ (1994) Antisense BCR-ABL oligonucleotides induce apoptosis in the Philadelphia chromosome-positive cell line BV173. Leukemia 8: 129-140
17. ten Hoeve J, Arlinghaus RB, Guo JC, Heisterkamp N and Groffen J (1994) Tyrosine phosphorylation of CRKL in Philadelphia and leukemia. Blood 84: 1731-1736
18. Valius M and Kazlauskas A (1993) Phospholipase C-γ1 and phosphatidylinositol 3-kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73: 321-334