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Volumn 27, Issue 48, 1986, Pages 5865-5868

Simple optical resolution of terleucine

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0000469739     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)85348-4     Document Type: Article
Times cited : (24)

References (26)
  • 4
    • 84985234389 scopus 로고
    • Asymmetrische Synthesen über heterocyclische Zwischenstufen, XXIII. Studien zur enantioselektiven Synthese von α-Alkyl-α-(2-furyl)-glycinen durch Alkylieren von an C-6 chiral substituierten 3-(2-Furyl)-3,6-dihydro-2H-1,4-oxazin-2-onen
    • (1984) Liebigs Annalen der Chemie , pp. 939
    • Schöllkopf1    Schever2
  • 5
    • 0019160956 scopus 로고
    • Synthesis, Enzymic Degradation, Lipophilic Properties, and Biological Activity of [D-Alanine2,t-butylglycine5]enkephalin Amide
    • (1980) Helvetica Chimica Acta , vol.63 , pp. 825
    • Fauchère1    Peterman2
  • 21
    • 84918447732 scopus 로고    scopus 로고
    • 12
  • 22
    • 84918447731 scopus 로고    scopus 로고
    • In the isothermal solubility diagram of figure 1, the compositions are expressed in g per 100 g of the whole mixture (g%); solubility of the less soluble salt (F) in 95% ethanol, 20°C, ca. 11 g%; eutectic composition (E), concentration ca. 34 g%, with 40% excess of the more soluble salt; solid solution boundary (H) ca. 45% excess of the less soluble salt.
  • 23
    • 84918447730 scopus 로고    scopus 로고
    • Melting point were recorded on a Perkin Elmer DSC2 differential microcalorimeter connected to a HP86 computer for data acquisition and processing; scanning rate 5 K/min, sample size ca. 1.5 mg.
  • 24
    • 84918447729 scopus 로고    scopus 로고
    • 14 for L-terleucine.
  • 25
    • 84918447728 scopus 로고    scopus 로고
    • The N-trifluoroacetyl-isopropyl ester of this sample showed a single peak by g.l.c. analysis on a Chrompack S-Valine-S-phenylethylamide capillary column, 50 m length, 110°C, carrier gas He 1..5 bar; a racemic sample was fully resolved under these conditions, with α ~1.037 and the D isomer first eluted; 1% of the other enantiomer in the resolved samples would have been detected. We thank Dr R. Azerad (Faculté de Médecine, Paris) for these measurements.
  • 26
    • 84918447727 scopus 로고    scopus 로고
    • No m.p. could be recorded by DSC for L-, D-, or DL-1, due to sublimation above 200°C.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.