Synthesis of Amphiphilic Piperidinium Derivatives. Cationic Lipids 4

Synlett

Volumn 1996, Issue 7, 1996, Pages 619-

  Solodin, Igor ^a   Heath, Timothy D ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000466220     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1996-5576     Document Type: Article

References (15)

1. Part 3 of this series: Solodin, I.; Heath, T.D. Synlett 1996, 617.
2. Felgner, P.L., Gadek, T.R., Holm, M., Roman, R., Chan, H.W., Wenz, M., Northrop, J.P., Ringold, G.M., and Danielsen, M. Proc. Natl. Acad.Sci. U.S.A. 1987, 84, 7413.
3. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
4. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
5. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
6. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
7. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
8. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
9. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
10. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
11. Betageri, G.V., Jenkins, S.A., Parsons, D.L. Liposome Drug Delivery Systems; Technomic: Lancaster, 1993; Debs, R.J. In Liposomes as Tools in Basic Research, Philippot R.J., Schuber, F., Eds.; CRC: Boca Raton, 1994; p.171; Lasic, D.D. Liposomes: from Physics to Applications; Elsevier: Amsterdam, 1993. Behr, J-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J.. Proc. Natl. Acad.Sci U.S.A. 1989, 86, 6982. Farhood, H., Bottega, R., Epand, R.M., and Huang, L. Biochim. Biophys. Acta 1992, 1111, 239. Gao, X. and Huang, L. Biochem. Biophys. Res. Commun. 1991, 179, 280. Rose, J.K., Buonocore, L., and Whitt, M.A. Biotechniques 1991, 10, 520. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G., and Jesse, J. Focus 1993, 15, 73. Ruysschaert, J-M., El Ouahabi, A., Willeaume, V., Huez, G., Fuks, R., Vandenbrabden, M., and Di Stefano, P. Biochem. Biophys. Res. Commun. 1994, 203, 1622.
12. Zhu, N., Liggitt, D., Liu, Y., and Debs, R. Science 1993, 261, 209, Solodin, I., Brown, C.S., Bruno, M.S., Chow, C.Y., Jang, E.H., Debs, R.J., Heath, T.D. Biochemistry 1995, 34, 13537.
13. Zhu, N., Liggitt, D., Liu, Y., and Debs, R. Science 1993, 261, 209, Solodin, I., Brown, C.S., Bruno, M.S., Chow, C.Y., Jang, E.H., Debs, R.J., Heath, T.D. Biochemistry 1995, 34, 13537.
14. Both 4a and 4b compounds have shown high efficiency of gene delivery in cell culture (unpublished results).
15. All products were fully characterized by appropriate spectral data.