Synthesis of the first examples of the imidazo[4,5-c]isoxazole ring system

Journal of the Chemical Society - Perkin Transactions 1

Volumn , Issue 7, 1999, Pages 817-825

  Tennant, George ^a,c   Wallis, Christopher J ^b   Weaver, George W ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000385484     PISSN: 0300922X     EISSN: None     Source Type: Journal    
DOI: 10.1039/a808292h     Document Type: Article

References (12)

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2. (a) G. Cristalli, A. Eleuteri, S. Vittori, R. Volpini, M. J. Lohse and K.-N. Kotz, J. Med. Chem., 1992, 35, 2363;
3. G. Cristalli, P. Franchetti, M. Grifantini, S. Vittori, K..-N. Klotz and M. J. Lohse, J. Med. Chem., 1988,31, 1179.
4. For a discussion of the chemistry of nitroimidazoles see J. H. Boyer, Nitroazoles: The C-Nilro Derivatives of Five-Membered N- and N,OHeterocycles, VCH, Deerfield Beach, 1986.
5. J. Sarasin and E. Wegman, Helv. Chim. Ada, 1924,7, 713.
6. O. Wallach, Liebigs. Ann. Chem., 1877,184, 51; 1882,214, 257.
7. H. C. Godt Jr. and F. F. Blicke, J. Org. Chem., 1969,34,2008.
8. For a review on the neighbouring group reactivity of the nitro group see P. N. Preston and G. Tennant, Chem. Rev., 1972,72,627.
9. C. A. Grob and O. Weissbach, Heir. Chim. Acta, 1961,4,1748.
10. K. J. Duffy and G. Tennant, J. Chem. Soc., Chem Commun., 1995, 2457.
11. G. W. Weaver, PhD Thesis, University of Edinburgh, 1990.
12. B. Radziszewski, Chem. Ber., 1869,2, 207.