Enzymatic synthesis of [1-13C]-and [1-14C]-L-phenylalanine

Isotopes in Environmental and Health Studies

Volumn 34, Issue 4, 1998, Pages 335-339

  Jemielity, J ^a   Kanska M ^a   Kanski R ^a  

^a UNIVERSITY OF WARSAW   (Poland)

Author keywords

Amino acids; Carbon 13; Carbon 14; Enzyme reaction; Stereospecificity

Indexed keywords

EID: 0000342031     PISSN: 10256016     EISSN: None     Source Type: Journal    
DOI: 10.1080/10256019808234070     Document Type: Article

References (15)

1. E. A. Havir and K. R. Hanson: L-Phenylalanine ammonia-lyase. II. Mechanism and kinetic properties of the enzyme from potato tubers. Biochemistry 7 (1968) 1904-1914
2. E. A. Havir and K. R. Hanson: L-Phenylalanine ammonia-lyase. (maise and potato and Rhodotorula glutinis). Studies with nitromethane. Biochemistry 14 (1975) 1620-1626
3. D. S. Hodgins: Yeast phenylalanine ammonia lyase. J. Biol. Chem. 246 (1971) 2977-2985
4. K. R. Hanson, R. H. Wightman, J. Staunton and A. R. Batersby: Stereochemical course of the elimination catalysed by L-Phenylalanine ammonia-lyase and the configuration of 2-benzamidocinnamic azlactone. J. Chem. Soc. (D) (1971) pp. 185-186
5. 14C] cinnamic acid. Ind. J. Biochem. Biophys. 18 (1981) 356-358
6. 14C]phenylalanine using L-phenylalanine ammonia-lyase. Enzyme Microb. Technol. 3 (1981) 73-75
7. J. D. Hermes, C. A. Roeske, M. H. O'Leary and W. W. Cleland: Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose 6-phosphate dehydrogenase. Biochemistry 21 (1982) 5106-5114
8. J. D. Hermes, P. M. Weiss and W. W. Cleland: Use of nitrogen-15 and deuterium isotope effects to determine the chemical mechanism of phenylalanine ammonia-lyase. Biochemistry 24 (1985) 2959-2967
9. J. Sühnel and R. L. Schowen: Theoretical Basis for Primary and Secondary Hydrogen Isotope Effects. In: F. Cook (Editor), Enzyme Mechanism from Isotope Effects. Boca Raton, Ann Arbor, Boston, London, CRS (1991) pp. 3-36
10. W. P. Huskey: Origins and Interpretations of Heavy-atom Isotope Effects. In: F. Cook (Editor), Enzyme Mechanism from Isotope Effects. Boca Raton, Ann Arbor, Boston, London, CRS (1991) pp. 37-73
11. C. H. Wong and G. M. Whitesides: Enzymes in Synthetic Organic Chemistry. Oxford, Pergamon (1994) pp. 9-40, 313
12. D. M. LeMaster and J. E. Cronan Jr.: Biosynthetic production of carbon-13-labeled amino acids with site-specific enrichment. J. Biol. Chem. 257 (1982) 1224-1230
13. 11C] phenylalanine. J. Labelled Compd. Radiopharm. 23 (1986) 715-722
14. A. Hädener and C. Tamm: Synthesis of specifically labelled phenylalanines using phenylalanine ammonia lyase activity. J. Labelled Compd. Radiopharm. 24 (1987) 1291-1305
15. A. Murray, III and D. L. Williams: Organic Syntheses with Isotopes. New York, Interscience Pub., Inc. (1958) pp. 218-230