Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 82, Issue 7, 1985, Pages 2173-2177

  Javitch, J A ^a   D'Amato, R J ^a   Strittmatter, S M ^a   Snyder, S H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 4 PHENYLBICYCLO[2.2.2]OCTANE; 1 METHYL 4 PHENYLPYRIDINIUM; 1 METHYL 4 PHENYLPYRIDINIUM H 3; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE H 3; 3',4' DICHLORO 2 (2 IMIDAZOLIN 2 YLTHIO)ACETOPHENONE; BENZATROPINE MESILATE; CITALOPRAM; DESIPRAMINE; DOPAMINE; DOPAMINE H 3; MAZINDOL; MAZINDOL H 3; NOMIFENSINE; NORADRENALIN; NORADRENALIN H 3; PARGYLINE; RADIOISOTOPE; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CORPUS STRIATUM; DRUG ACCUMULATION; DRUG INTERACTION; INTOXICATION; NERVOUS SYSTEM; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0000340348     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.82.7.2173     Document Type: Article

References (0)