No Evidence for Cognitive Side Effects after 6 Months of Vagus Nerve Stimulation in Epilepsy Patients

Epilepsy and Behavior

Volumn 2, Issue 4, 2001, Pages 351-356

  Hoppe, Christian ^a,b   Helmstaedter, Christoph ^b   Scherrmann, Judith ^b   Elger, Christian E ^b  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Cognition; Epilepsy; Neuropsychology; Vagus nerve stimulation

Indexed keywords

EID: 0000333839     PISSN: 15255050     EISSN: None     Source Type: Journal    
DOI: 10.1006/ebeh.2001.0219     Document Type: Article

References (20)

1. Ben Menachem E, Manon Espaillat R, Ristanovic R, et al. Vagus nerve stimulation for treatment of partial seizures: 1. A controlled study of effect on seizures (First International Vagus Nerve Stimulation Study Group). Epilepsia 1994;35:616-26.
2. Handforth A, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology 1998;51:48-55.
3. Ramsay RE, Uthman BM, Augustinsson LE, et al. Vagus nerve stimulation for treatment of partial seizures: 2. Safety side effects and tolerability (First International Vagus Nerve Stimulation Study Group). Epilepsia 1994;35:627-36.
4. Schachter SC, Saper CB. Vagus nerve stimulation. Epilepsia 1998;39:677-86.
5. Rutecki P. Anatomical physiological and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia 1990;31(suppl 2):S1-6.
6. Rogers RC, McTigue DM, Hermann GE. Vagal control of digestion: modulation by central neural and peripheral endocrine factors. Neurosci Biobehav Rev 1996;20:57-66.
7. Randich A, Gebhart GF. Vagal afferent modulation of nociception. Brain Res Rev 1992;17:77-99.
8. Uvnas Moberg K. Role of efferent and afferent vagal nerve activity during reproduction: integrating function of oxytocin on metabolism and behaviour. Proceedings of the International Conference on Hormones Brain and Behaviour (1993 Tours/ France). Psychoneuroendocrinology 1994;19:687-95.
9. Porges SW, Doussard-Roosevelt JA, Maiti AK. Vagal tone and the physiological regulation of emotion. Monogr Soc Res Child Dev 1994;59:167-86.
10. Clark KB, Krahl SE, Smith DC, Jensen RA. Post-training unilateral vagal stimulation enhances retention performance in the rat. Neurobiol Learn Mem 1995;63:213-6.
11. Clark KB, Smith DC, Hassert DL, Browning RA, Naritoku DK, Jensen RA. Posttraining electrical stimulation of vagal afferents with concomitant vagal efferent inactivation enhances memory storage processes in the rat. Neurobiol Learn Mem 1998;70: 364-73.
12. Clark KB, Naritoku D, Smith DC, Browning RA, Jensen RA. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nat Neurosci 1999;2:94-8.
13. Dodrill CB. Cognitive and quality of life changes with VNS therapy: results from a randomized controlled trial [abstract]. In: Current Results and Perspectives on Vagus Nerve Stimulation for the Treatment of Epilepsy, Cyberonics Houston TX, 1997.
14. Dodrill CB, Morris GL. Effects of vagal nerve stimulation on cognition and quality of life in epilepsy. Epilepsy Behav 2001; 2:46-53.
15. Helmstaedter C, Gleissner U, Zentner J, Elger CE. Neuropsychological consequences of epilepsy surgery in frontal lobe epilepsy. Neuropsychologia 1998;36:333-41.
16. George R, Salinsky M, Kuzniecky R, et al. Vagus nerve stimulation for treatment of partial seizures: 3. Long-term follow-up on first 67 patients exiting a controlled study (First International Vagus Nerve Stimulation Study Group). Epilepsia 1994; 35:637-43.
17. Harden CL, Pulver MC, Ravdin LD, Nikolov B, Halper JP, Labar DR. A pilot study of mood in epilepsy patients treated with vagus nerve stimulation. Epilepsy Behav 2000; 1:93-9.
18. Elger G, Hoppe C, Falkai P, Rush JA, Elger CE. Vagus nerve stimulation is associated with mood improvements in epilepsy patients. Epilepsy Res 2000;42:203-10.
19. Rush AJ, George MS, Sackheim HA, et al. Vagus nerve stimulation (VNS) for treatment-resistant depression: a multicenter study. J Biol Psychiatry 2000;47:276-86.
20. Hoppe C, Helmstaedter C, Scherrmann J, Elger CE. Self-reported mood changes following 6 months of vagus nerve stimulation in epilepsy patients. Epilepsy Behav 2001;2:335-42.