Synthesis of protected 5-formylpyrido[2,3-d] pyrimidine via a 2,3,4-trisubstituted pyridine using an ortho-litmation strategy; applicationtothe synthesis of a folate derivative

Heterocycles

Volumn 48, Issue 10, 1998, Pages 2149-2155

  Watson, Samuel E ^a   Markovich, Anatoly ^a  

^a LONG ISLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000258116     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-98-8265     Document Type: Article

References (10)

1. (a) E. C. Taylor, In Chemistry and Biology of Pteridines and Folates, ed. by J. E. Aylung, Plenum Press, New York, 1993, pp. 387-408 and references therein,
2. (b) G. M. C. Bisset, K. Pawelczak, A. L. Jackman, and A. H. Calvert, J. Med. Chem., 1992, 3 5,859 and references therein,
3. (c) E. C. Taylor, D. Kuhnt, C. Shih, S. M. Rinzel, G. B. Grindey, J. Barredo, M. Jannatipour, and R. G. Moran, J. Med. Chem., 1992, 35, 4450.
4. (d) C. Shih, L. S. Gosset, S. B. Gates, W. C. MacKellar, L. G. Mendelsohn, D. J. Soose, V. F. Patel, W. Kohler, and M. Ratnam, Proceedings of the 9th NCI-EORTC Symposium on New Drugs in Cancer Therapy, 1996, 289, 85.
5. (a) T. L. Su and K. Watanbe, J. Org. Chem., 1989, 54, 220.
6. (b) E. C. Taylor, E. C. Palmer, T. J. George, S. R. Flectcher, C. P. Tseng, P. J. Harrington, and G. P. Beardsley, J. Org. Chem., 1983, 48, 4852.
7. (a) J. R. Dormoy and A. Heymes, Tetrahedron, 1993, 49, 2885.
8. For leading references see (b) D. L. Comins and E. D. Stroud, J. Heterocycl. Chem., 1985, 22, 1419.
9. (c) A. R. Katritzky, W. Fau, A. E. Koziol, and G. J. Palenik, Tetrahedron, 1987, 43, 2343.
10. (d) D. L. Comins and A. H. Abdullah, J. Org. Chem., 1982, 47, 4315.