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The byproduct 9 resulted from a partial dialkylation of the thioester 8 in some experiments.
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Lactone 14d, epimer in C2 of the desired lactone 10d, was observed under the following conditions-long duration time or excess of TsOH - during the lactonization step (Table 5, entries 1-4). Irradiation of the proton H4 led to a selective Overhauser effect on H2 (4%).
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Irradiation of the proton H4 led to a selective Overhauser effect on H2 (5% )
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Irradiation of the proton H4 led to a selective Overhauser effect on H2 (5% ).
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These compounds have been prepared using lactones as synthetic intermediates. See, for example: (a) β-Angelica lactone: Camps, P.; Cardellah, J.; Corbera, J.; Font, J.; Ortuño, R. M.; Ponsati, O. Tetrahedron 1983, 39, 395.
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