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1
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0642304219
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note
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Sponsorship of this work by the National Science Foundation (Grant 9414113) is gratefully acknowledged.
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See, for example: (a) Radi, R.; Beckman, J. S.; Bush, K. M.; Freeman, B. A. J. Biol. Chem. 1991, 266, 4244 (thiols). (b) Pryor, W. A.; Jin, X.; Squadrito, G. L. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 11173 (thioethers). (c) Beckman, T. W.; Chen, J.; Marshall, P. A.; Freeman, B. A. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 1620 (1,2-glycols). (d) Ischioropoulos, H.; Zhu, L.; Chen, M.; Tsai, M.; Martin, J. C.; Smith, C. D.; Beckman, J. S. Arch. Biochem. Biophys. 1992, 298, 431 (amino acids). (e) Bartlett, D.; Church, D. F.; Bounds, P. L.; Koppenol, W. H. Free Radical Biol. Med. 1995, 18, 85 (ascorbate).
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See, for example: (a) Radi, R.; Beckman, J. S.; Bush, K. M.; Freeman, B. A. J. Biol. Chem. 1991, 266, 4244 (thiols). (b) Pryor, W. A.; Jin, X.; Squadrito, G. L. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 11173 (thioethers). (c) Beckman, T. W.; Chen, J.; Marshall, P. A.; Freeman, B. A. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 1620 (1,2-glycols). (d) Ischioropoulos, H.; Zhu, L.; Chen, M.; Tsai, M.; Martin, J. C.; Smith, C. D.; Beckman, J. S. Arch. Biochem. Biophys. 1992, 298, 431 (amino acids). (e) Bartlett, D.; Church, D. F.; Bounds, P. L.; Koppenol, W. H. Free Radical Biol. Med. 1995, 18, 85 (ascorbate).
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See, for example: (a) Radi, R.; Beckman, J. S.; Bush, K. M.; Freeman, B. A. J. Biol. Chem. 1991, 266, 4244 (thiols). (b) Pryor, W. A.; Jin, X.; Squadrito, G. L. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 11173 (thioethers). (c) Beckman, T. W.; Chen, J.; Marshall, P. A.; Freeman, B. A. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 1620 (1,2-glycols). (d) Ischioropoulos, H.; Zhu, L.; Chen, M.; Tsai, M.; Martin, J. C.; Smith, C. D.; Beckman, J. S. Arch. Biochem. Biophys. 1992, 298, 431 (amino acids). (e) Bartlett, D.; Church, D. F.; Bounds, P. L.; Koppenol, W. H. Free Radical Biol. Med. 1995, 18, 85 (ascorbate).
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Reactions at lower pH's, which proceed at rates measurable by flow methods, were not examined in detail since reagents appeared to become irreproducibly contaminated, on mixing, with traces of dissolved copper arising from corroded surfaces of the metal valves in our flow system.
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note
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28 should not be greatly altered by the partial conversion of the copper species to soluble hydroxo complexes.
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11) was neglected, were not successful.
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note
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. reaction (13). Although we cannot rule out such a dimerization as a minor path, a major contribution of this type would not be compatible with what is observed as the stoic biometry approaches 1:1.
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