Immunostimulating Activity and Characterization of Polysaccharides from Mycelium of Phellinus linteus

Journal of Microbiology and Biotechnology

Volumn 6, Issue 3, 1996, Pages 213-218

  Lee, Jae Hoon ^a   Cho, Soo Muk ^a   Song, Kyung Sik ^a   Han, Sang Bae ^a   Kim, Hwan Mook ^a   Hong, Nam Doo ^b   Yoo, Ick Dong ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Bangchon Nat Prod Res Institute   (South Korea)

Author keywords

Immunostimulating activity; Phellinus linteus; Polysaccharide

Indexed keywords

EID: 0000236961     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Adachi, Y., N. Ohno, M. Ohsawa, S. Oikawa, and T. Yadomae. 1990. Change of biological activities of β(1→3)-D-glucan from Grifola frondosa upon molecular weight reduction by heat treatment. Chem. Pharm. Bull. 38: 477-481.
2. Blumenkrantz, N. and G. Asboe-Hansen. 1973. New methods for quantitative determination of uronic acids. Anal. Biochem. 54: 484-489.
3. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
4. Chihara, G., J. Himuri, Y. Y. Maeda, Y. Arai, and F. Fukuoka. 1970. Fractionation and purification of the polysaccharides with marked antitumor activity, especially, lentinan, from Lentinus edodes (Berk) SING. Cancer Res. 30: 2776-2781.
5. Cho, S. M., J. H. Lee, S. B. Han, H. M. Kim, S. H. Yu, and I. D. Yoo. 1995. Immuno-stimulating polysaccharides from the fruiting bodies of Fomitella fraxinea. (I): Characterization of polysaccharides extracted with neutral sodium chloride solution. Kor. J. Mycol. 23: 332-339.
6. Cho, S. M., J. H. Lee, S. B. Han, H. M. Kim, S. H. Yu, and I. D. Yoo. 1995. Immuno-stimulating polysaccharides from the fruiting bodies of Fomitella fraxinea. (II): Isolation and characterization of hot-water extracted polysaccharides. Kor. J. Mycol. 23: 340-347.
7. Domer, J. E. and R. E. Garner. 1991. Fungal wall components and immunostimulation, p. 157-167. In J. P. Latge, and D. Boucias (eds.), Fungal cell wall and immune response, Springer-Verlag, Berlin Heidelberg.
8. Dubois, M. K. A. Gules, J. K. Hamilton, P. A. Roberts, and F. Smith. 1956. Colorimetric method for determination of sugars and related substances. Anal. Chem. 28: 350-356.
9. Franz, G. 1989. Polysaccharides in pharmacy: current applications and future concepts. Planta Med. 55: 493-497.
10. Grzybek, J., I. Zgorniak-Nowosielska, and S. Kohlmunzer. 1990. Antitumor and cytotoxic activity of Tylopilan, a fungal polysaccharide from Tylopilus felleus fruit bodies. Planta Med. 56: 670-671.
11. Han, M. W., K. S. Ko, and K. S. Chung. 1995. Liquid cultivation of Phellinus linteus mycelium and preparation of antitumor and immunostimulating substance. Korea Patent Open No. 95-7860.
12. Honda, S., H. Sugino, T. Asano, and A. Kakimuma. 1986. Activation of the alternative pathway of complement by an antitumor (1→3)-β-D-glucan from Alcaligenes faecalis var. myxogenes IFO 013140, and its lower molecular weight and carboxymethylated derivatives. Immunophamacol. 11: 29-37
13. Hyun, J. W., E. C. Choi, and B. K. Kim. 1990. Studies on constituents of higher fungi of Korea (LXVII): antitumor components of the basidiocarp of Ganoderma lucidum. Kor. J. Mycol. 18: 58-69.
14. Ingolfsdottir, K., K. Jurcic, B. Fischer, and H. Wagner. 1994. Immunologically active polysaccharide from Cetraria islandica. Planta Med. 60: 527-531.
15. Kiho, T., Y. Shiose, K. Nagai, and S. Ukai. 1992. Polysaccharides in fungi XXX. antitumor and immunostimulating activities of two polysaccharides from the fruiting bodies of Armillariella tabescens. Chem. Pharm. Bull. 40: 2110-2114.
16. Kishida, E., Y. Sone, and A. Misaki. 1992. Effects of branch distribution and chemical modifications of antitumor (1→3)-β-D-glucans. Carbohydr. Polymers 17: 89-95.
17. Kobayashi, Y., K. Kariya, K. Saigenji, and K. Nakamura. 1994. Suppression of cancer cell growth in vitro by the protein-bound polysaccharide of Coriolus versicolor QUEL (PS-K) with SOD mimicking activity. Cancer Biothra. 9: 63-69.
18. Kwag, S. D., J. W. Bok, J. W. Hyun, E. C. Choi, and B. K. Kim. 1992. Studies on constituents of higher fungi of Korea (LXXIII): antitumor components of the cultured mycelia of Paxillus atrotomentosus. Kor. J. Mycol. 20: 240-251.
19. Lee, J. H. 1994. Anti-tumor and immune-stimulating activity of fungal polysaccharides. Mciroor. Ind. 20: 14-21.
20. Ma, Y., T. Mizuno, and H. Ito. 1991. Antitumor activity of some polysaccharides isolated from a Chinese mushroom, Huangmo, the fruiting body of Hohenbuehelia serotina. Agric. Biol. Chem. 55: 2701-2710.
21. Maeda, Y. Y., K. Ishimura, and G. Chihara. 1976. Antitumor polysaccharides and host defence against cancer: a new way for cancer immuno-chemotherapy. Protein Nucleic Acid Enzyme 21: 426-436.
22. Misaki, A., K. Kawaguchi, H. Miyaji, H. Nagae, S. Hokkoku, M. Kakuta, and T. Sasaki. 1984. Structure of pestalotan, a highly branched (1→3)-β-D-glucan elaborated by Pestalotia sp. 815, and the enhancement of its antitumor activity by polyol modification of the side chains. Carbohydr. Res. 129: 209-227.
23. Mizuno, T., T. Kinoshita, C. Zhuang, H. Ito, and Y. Mayuzumi. 1995. Antitumor-active heteroglycans from Nioshimeji Mushroom, Tricholoma giganteum. Biosci. Biotech. Biochem. 59: 568-571.
24. Oh, G. T., S. B. Han, H. H. Kim, M. W. Han, and I. D. Yoo. 1992. Immunostimulating activity of Phellinus Unteus extracts to B-lymphocyte. Arch. Pharm. Res. 15: 379-381.
25. Sasaki, T. and N. Takasuka. 1971. Further study of structure of lentinan, as antitumor polysaccharide from Lentinus edodes. Carbohydr. Res. 47: 99-104.
26. Schauer, R. 1978. Characterization of sialic acids, p. 64-89. In V. Ginsburg (ed.), Methods in enzymology, vol. 50. Academic press, London.
27. Song, K. S., S. M. Cho, J. H. Lee, H. M. Kim, S. B. Han, K. S. Ko, and I. D. Yoo. 1995. B-lymphocyte stimulating polysaccharide from mushroom Phellinus linteus. Chem. Pharm. Bull. 43: 2105-2108.
28. Tabata, K., W. Itoh, T. Kojima, S. Kawabate, and K. Misaki, 1981. Ultrasonic degradation of schizophyllan, an antitumor polysaccharide produced by Schizophyllum commune FRIES. Carbohydr. Res. 89: 121-135.
29. Tsukagoshi, S. and F. Ohashi. 1974. Protein-bound polysaccharide preparation, PS-K, effective against mouse sarcoma 180 and rat ascites hepatoma AH-13 by oral use. Gann. 65: 557-558.
30. Yoo, I. D., J. H. Lee, and S. M. Cho. 1995. Development of screening system and discovery of bioactive substances: screening and identification of antimicrobial and bioactive compounds (III), p. 73-117. BSNB81370-732-3.