In vivo distribution and gene expression of genetically modified hepatocytes after intrasplenic transplantation

Science in China, Series C: Life Sciences

Volumn 40, Issue 5, 1997, Pages 554-560

  Zhang, Weiping ^a   Cao, Xuetao ^a   Huang, Xin ^a   Wang, Jianli ^a   Tao, Qun ^a   Ye, Tianxing ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Gene expression; Gene therapy; Hepatocytes; Interleukin 2; Intrasplenic transplantation

Indexed keywords

EID: 0000211954     PISSN: 10069305     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03183596     Document Type: Article

References (9)

1. Strauss, M., Liver-directed gene therapy : prospects and problems, Gene Ther., 1994, 1; 156.
2. Wilson, J.M., Grossman, M., Raper, S. E. et al., Ex viva gene therapy of familial hypercholesterolemia, Hum . Gene Ther., 1992, 3; 179.
3. Gupta, S., Aragona, E., Vemuru, R. P. et al., Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation, Hepatology, 1991, 14; 144.
4. Gupta, S., Yemeni, P.R., Vemuru, R.P. et al., Studies on the safety of intrasplenic hepatocyte transplantation: relevance to ex vivo gene therapy and liver repopulation in acute hepatic failure, Hum . Gene Ther., 1993, 4: 249.
5. Cao Xuetao, Zhang Weiping, Tao Qun et al., Enhanced immune functions and antitumor activity of fibroblast-mediated IL-2 gene therapy, National Medical Journal of China (in Chinese), 1995, 75(9): 521.
6. Mine, M., Arii, S., Higashitsuji, H. et al., Augmented local immunity in the liver by a streptococcal preparation, OK432, related to antitumor activity of hepatic macrophages, Immunopharmacol, 1994, 27: 31.
7. Zhang Weiping, Cao Xuetao, Gu Shen et al., Augmented natural killer cytotoxicity by human interleukin-6 gene-transfected fibroblasts, Chinese Journal of Hematology (in Chinese), 1994, 15: 300.
8. Rosenberg, S.A., Aebersold, P., Cprnetta, K. et al., Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction, N. Engl. J. Med., 1990, 323: 570.
9. Vemuru, R.P., Yermemi, P., Aragona, E. et al., Survival and function of hepatocytes in ectopic sites: intrasplenic delivery confers advantages, Hepatology, 1991, 14; 49A.