Origins of the aminoglycoside modifying enzymes

Drug Resistance Updates

Volumn 1, Issue 5, 1998, Pages 285-291

  Rather, Philip N ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000187517     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-7646(98)80044-7     Document Type: Review

References (64)

1. Ahmad M.H., Rechenmacher A., and Böck A. Interaction between aminoglycoside uptake and ribosomal resistance mutations. Antimicrob Agents Chemother 18 (1980) 798-806
2. Aínsa J.A., Martin C., Gicquel B., and Gomez-Lus R. Characterization of the chromosomal aminoglycoside 2′-N-acetyltransferase gene from Mycobacterium fortuitum. Antimicrob Agents Chemother 40 (1996) 2350-2355
3. Aínsa J.A., Pérez E., Pelicic V., et al. Aminoglycoside 2′-N-acetyltransferase genes are universally present in mycobacteria: characterization of the aac(2′)-lc from Mycobacterium tuberculosis and the aac(2′)-ld gene from Mycobacterium smegmatis. Mol Microbiol 24 (1997) 431-441
4. Bhasin N., Albus A., Michon F., et al. Identification of a gene essential for O-acetylation of the Staphylococcus aureus type 5 capsular polysaccaride. Mol Microbiol 27 (1998) 9-21
5. Benveniste R., and Davies J. Aminoglycoside inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic resistant bacteria. Proc Nat Acad Sci USA 70 (1973) 2276-2280
6. Benveniste R., and Davies J. Mechanisms of antibiotic resistance in bacteria. Annu Rev Biochem 42 (1973) 471-506
7. Bloemberg G.V., Thomas-Oates J.E., Lugtenberg B.J., and Spaink H.P. Nodulation protein NodL of Rhizobium leguminosarium O-acetylates lipo-oligosaccarides, chitin fragments and N-acetylglucosamine in vitro. Mol Microbiol 11 (1994) 793-804
8. Brenner S. Phosphotransferase sequence homology. Nature 329 (1987) 21
9. Bryan L.E., and Van Den Elzen H.M. Effects of membrane energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model for entry of streptomycin and gentamicin in susceptible and resistant bacteria. Antimicrob Agents Chemother 12 (1977) 163-177
10. Buckel P., Buchberger A., Böck A., and Wittmann H.G. Alteration of ribosomal protein L6 in mutants of Escherichia coli resistant to gentamicin. Mol Gen Genet 158 (1977) 47-54
11. Chevereau M., Daniels P.J.L., Davies J., and LeGoffic F. Aminoglycoside resistance in bacteria mediated by gentamicin acetyltransferase li, an enzyme modifying the 2′ amino group of aminoglycoside antibiotics. Biochemistry 13 (1974) 598-603
12. Clarke A.J., and Dupont C. O-acetylated peptidoglycan: its occurrence, pathobiological significance, and biosynthesis. Can J Microbiol 38 (1992) 85-91
13. Clarke A.J. Extent of peptidoglycan O-acetylation in the tribe Proteeae. J. Bacteriol. 175 (1993) 4550-4553
14. Clarke A.J., Francis D., and Keenleyside W.J. The prevelance of gentamicin 2′-N-acetyltransferase in the Proteeae and its role in the O-acetylation of peptidoglycan. FEMS Microbiol Letters 145 (1996) 201-207
15. Costa Y., Galimand M., Leclercq R., Duval J., and Courvalin P. Characterization of the chromosomal aac(6′)-li gene specific for Enterococcus faecium. Antimicrob Agents Chemother 37 (1993) 1896-1903
16. Cundliffe E. How antibiotic-producing organisms avoid suicide. Annu Rev Microbiol 43 (1989) 207-233
17. Cundliffe E. The molecular basis of antibiotic action. In: Gale E.F., et al. (Ed) (1981), John Wiley and Sons, New York 401-457
18. Daigle D.M., McKay G.A., and Wright G.D. Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors. J Biol Chem 272 (1997) 24755-24758
19. Davies J., and Davis B.D. Misreading of ribonucleic acid code words induced by aminoglycoside antibiotics. J Biol Chem 243 (1968) 3312-3317
20. Davies J., and Wright G.D. Bacterial resistance to aminoglycoside antibiotics. Trends Microbiol 5 (1997) 234-240
21. Davis B.D., Chen L.L., and Tai P.C. Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proc Natl Acad Sci USA 83 (1986) 6164-6168
22. Davis B.D. Mechanism of bactericidal activity of aminoglycosides. Microbiol Rev 51 (1987) 341-350
23. Funatsu G., and Wittmann H.G. Ribosomal proteins. Location of amino acid replacements in protein S12 isolated from Escherichia coli mutants resistant to streptomycin. J Mol Biol 68 (1972) 547-550
24. Hancock R. Aminoglycoside uptake and mode of action-with special reference to streptomycin and gentamicin. J Antimicrob Chemother 8 (1981) 249-276
25. Hancock R. Alterations in outer membrane permeability. Annu Rev Microbiol 38 (1984) 237-264
26. Holm L., and Sander C. DNA polymerase β belongs to an ancient nucleotidyltransferase superfamily. Trends Biochem Sci 20 (1995) 345-347
27. Holmes D.J., and Cundliffe E. Analysis of a ribosomal RNA methylase gene from Streptomyces tenebrarius which confers resistance to gentamicin. Mol Gen Genet 229 (1991) 229-237
28. Hon W.C., McKay G.A., Thompson P.R., et al. Structure of an enzymes required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases. Cell 89 (1997) 887-895
29. Kadurugamuwa J.L., Lam J.S., and Beveridge T.J. Interaction of gentamicin with the A band and B band lipopolysaccarides of Pseudomonas aeruginosa and its possible lethal effect. Antimicrob Agents Chemother 37 (1993) 715-721
30. Kadurugamuwa J.L., Clarke A.J., and Beveridge T.J. Surface action of gentamicin on Pseudomonas aeruginosa. J Bacteriol 175 (1993) 5798-5805
31. Lambert T., Gerbaud G., Galimand M., and Courvalin P. Characterization of an Acinetobacter haemolyticus aac(6′)-lg gene encoding an aminoglycoside 6′-N-acetyltransferase which modifies amikacin. Antimicrob Agents Chemother 37 (1993) 2093-2100
32. Lambert T., Germand G., and Courvalin P. Characterization of the chromosomal aac(6′)-lj gene of Acinetobacter sp.13 and the aac(6′)-lh plasmid gene of Acinetobacter baumannii. Antimicrob Agents Chemother 38 (1994) 1883-1889
33. Macinga D.R., Parojcic M.M., and Rather P.N. Identification and analysis of aarP, a transcriptional activator of the 2′-N-acetyltransferase in Providencia stuartii. J Bacteriol 177 (1995) 3407-3413
34. Macinga D.R., and Rather P.N. aarD, a Providencia stuartii homolog of cydD: Role in 2′-N-acetyltransferase expression, cell morphology and growth in the presence of an extracellular factor. Mol Microbiol 19 (1996) 511-520
35. Macinga D.R., Cook G., Poole R.K., and Rather P.N. Identification and characterization of aarF, a locus required for the production of ubiquinone in Escherichia coli and Providencia stuartii and for expression of the 2′-N-acetyltransferase. J Bacteriol 180 (1988) 128-135
36. Martin P., Jullien E., and Courvalin P. Nucleotide sequence of Acinetobacter baumannii aphA-6 gene:evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes. Mol Microbiol 2 (1988) 615-625
37. Mengin-Lecreulx D., and Van Heijenoort J. Copurification of glucosamine-l-phosphate acetyltransferase and N-acetylglucosamine-l-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis. J Bacteriol 176 (1994) 5788-5795
38. Ozaki M., Mizushima S., and Nomura M. Identification and functional characterization of the protein controlled by the streptomycin resistant locus in E. coli. Nature 222 (1969) 333-339
39. Paradise M.R., Cook G., Poole R.K., and Rather P.N. Mutations in aarE, the ubiA homolog of Providencia stuartii result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2′-N-acetyltransferase. Antimicrob Agents Chemother 42 (1998) 959-962
40. Payie K.G., Rather P.N., and Clarke A.J. Contribution of gentamicin 2′-N-acetyltransferase to the O-acetylation of peptidoglycan in Providencia stuartii. J Bacteriol 177 (1995) 4303-4310
41. Payie K.G., and Clarke A.J. Characterization of gentamicin 2′-N-acetyltransferase from Providencia stuartii: its use of peptidoglycan metabolites for acetylation of both aminoglycosides and peptidoglycan. J Bacteriol 179 (1997) 4106-4114
42. Piepersberg W., Distler J., Heinzel P., and Perez-Gonzalez J.A. Antibiotic resistance by modification: many resistance genes could be derived from cellular control genes in Actinomycetes. A hypothesis. Actinomycetologica 2 (1988) 83-98
43. Rather P.N., Orosz E., Hare R.S., Miller G., and Shaw K.J. Characterization and transcriptional regulation of the 2′-N-acetyltransferase gene of Providencia stuartii. J Bacteriol 175 (1993) 6492-6498
44. Rather P.N., and Orosz E. Characterization of aarA, a pleiotrophic negative regulator of the 2′-N-acetyltransferase in Providencia stuartii. J Bacteriol 176 (1994) 5140-5144
45. Rather P.N., Solinsky K., Paradise M.R., and Parojcic M.M. aarC, an essential gene involved in density dependent regulation of the 2′-N-acetyltransferase in Providencia stuartii. J Bacteriol 179 (1996) 2267-2273
46. Rather P.N., Paradise M.R., and Parojcic M.M. An extracellular factor regulating expression of the chromosomal aminoglycoside 2′-N-acetyltransferase in Providencia stuartii. Antimicrob Agents Chemother. 41 (1997) 1749-1754
47. In press. Rather P.N., Paradise M.R., Parojcic M.M., and Patel S. A regulatory cascade involving AarG, a putative sensor kinase controls expression of the 2′-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. Mol Microbiol (1998)
48. Rudant E., Bourlioux P., Courvalin P., and Lambert T. Characterization of the aac(6′)-lk gene of Acinetobacter sp.6. FEMS Microbiol Lett 124 (1994) 49-54
49. Rudant E., Courvalin P., and Lambert T. Loss of intrinsic aminoglycoside resistance in Acinetobacter haemolyticus as a result of three distinct types of alterations in the aac(6′)-lg gene, including insertion of IS17. Antimicrob Agents Chemother 41 (1997) 2646-2651
50. Salauze D., and Davies J. Isolation and characterisation of an aminoglycoside phosphotransferase from neomycin producing Micromonospora chalcea; comparison with that of Streptomycetes fradiae and other producers of 4,6-disubstituted 2-deoxystreptamine antibiotics. J Antibiot 44 (1991) 1432-1443
51. Salauze D., Perez-Gonzalez J.A., Piepersberg W., and Davies J. Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomycetes fradiae. Gene 101 (1991) 143-148
52. Shaw K.J., Rather P.N., Petrikkos G., Mann P., Sabatelli F., et al. Characterization of the chromosomal aac(6′)-lc gene from Serratia marcescens. Antimicrob Agents Chemother 36 (1990) 1447-1455
53. Shaw K.J., Rather P.N., Hare R.S., and Miller G.H. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside modifying enzymes. Microbiol Rev 57 (1993) 138-163
54. Taber H.W., Mueller J.P., Miller P.F., and Arrow A.S. Bacterial uptake of aminoglycoside antibiotics. Microbiol Rev 51 (1987) 439-457
55. Udou T., Mizuguchi Y., and Wallace Jr. R. Does aminoglycoside-acetyltransferase in rapidly growing mycobacteria have a metabolic function in addition to aminoglycoside inactivation?. FEMS Microbiol Letters 57 (1989) 227-230
56. Udou T., Mizuguchi Y., and Wallace Jr. R.J. Patterns and distribution of aminoglycoside-acetylating enzymes in rapidly growing mycobacteria. Am Rev Respir Dis 136 (1987) 338-343
57. Walker G.S., and Beveridge T.J. Amikacin disrupts the cell envelope of Pseudomonas aeruginosa ATCC9027. Can J Microbiol 34 (1988) 12-18
58. Walker J.B., and Skorvaga M. Phosphorylation of streptomycin and dihydrostreptomycin by Streptomycetes. J Biol Chem 248 (1973) 2435-2440
59. Wallace B.J., and Davis B.D. Cyclic blockade of initiation sites by streptomycin damaged ribosomes in Escherichia coli: an explanation for the dominance of sensitivity. J Mol Biol 75 (1973) 377-390
60. Webb V., and Davies J. Antibiotic preparations contain DNA: a source of drug resistance genes?. Antimicrob Agents Chemother 37 (1993) 2379-2384
61. Wright G.D., and Ladak P. Overexpression and characterization of the chromosomal aminoglycoside 6′-N-acetyltransferase from Enterococcus faecium. Antimicrob Agents Chemother 41 (1997) 956-960
62. Yamaguchi M., Mitsuhashi S., Kobayshi F., and Zenda H. A 2′-N-acetylating enzyme of aminoglycosides. J Antibiotics 27 (1974) 507-515
63. Young K., Silver L.L., Bramhill D., Cameron P., Eveland S.S., et al. The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase. J Biol Chem 270 (1995) 30384-30391
64. Zhang C.C. Bacterial signaling involving eukaryotic type protein kinases. Mol Microbiol 20 (1996) 9-15